A5101940865- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Protein Tyrosine Phosphatases
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Protein Kinase Regulation and GTPase Signaling
- Esophageal Cancer Research and Treatment
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Developmental Biology and Gene Regulation
- Kruppel-like factors research
- Metabolomics and Mass Spectrometry Studies
- Plant Genetic and Mutation Studies
- Polymer Surface Interaction Studies
Sichuan Cancer Hospital
2011-2025
University of Electronic Science and Technology of China
2019-2025
Southwest Medical University
2025
Jiangsu University
2024
Sichuan University
2009-2023
Wenzhou Medical University
2023
Shandong University of Science and Technology
2022
Ningbo Institute of Industrial Technology
2022
Chinese Academy of Sciences
2022
Nanjing Medical University
2009-2022
Abstract First-line systemic therapeutic options for advanced esophageal squamous cell carcinoma (ESCC) are limited. In this multicenter, double-blind phase 3 trial, a total of 551 patients with previously untreated, locally or metastatic ESCC and PD-L1 combined positive score ≥1 were randomized (2:1) to receive serplulimab (an anti-PD-1 antibody; mg/kg) placebo (on day 1), plus cisplatin (50 mg/m 2 ) 1) continuous infusion 5-fluorouracil (1,200 days 1 2), once every weeks. The study met the...
Abstract Background Chronic obstructive pulmonary disease (COPD) and cardiovascular (CVD) are two major age-related diseases prevalent in the elderly. However, it is unclear whether there a higher prevalence of one or more CVDs COPD patients compared to those without COPD, magnitude this increased prevalence. Methods This population-based cross-sectional study was conducted using data from National Health Nutrition Examination Survey (NHANES) 2013–2018 among American adults aged 40 years...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. We previously reported superior symptom control of electronic patient-reported outcome (ePRO)–based management...
Learning Objective Evaluate the changes in prevalence and clinical characteristics of cervical cancer China.
PURPOSE This study aimed to evaluate the safety and efficacy of ivonescimab (a bispecific antibody against programmed death-1 [PD-1] vascular endothelial growth factor [VEGF]) as first- or second-line monotherapy in advanced immunotherapy naïve non-small-cell lung cancer (NSCLC) patients. METHODS Eligible patients received intravenous 10mg/kg every 3 weeks (Q3W), 20 mg/kg 2 (Q2W), Q3W 30mg/kg Q3W. The primary endpoints were objective response rate (ORR) per RECIST v1.1. RESULTS At data...
Thymic epithelial tumors (TETs) are a relatively rare type of thoracic tumor, accounting for less than 1% all tumors. The incidence TETs is about 3.93/10000 in China, slightly higher that European and American countries. For resectable TETs, complete surgical resection recommended. Radiotherapy or chemotherapy may be used as postoperative adjuvant treatment. Treatment advanced, unresectable consist mainly radiotherapy chemotherapy, but there lack standard first- second-line treatment...
Metastasis is the leading cause of death for non‐small cell lung cancer (NSCLC) patients. However, how cells invade blood vessels during metastasis remains unclear. Here, based on bioinformatics analyses, we found that PLEK2 might regulate NSCLC migration and vascular invasion. As little known about function in NSCLC, aimed to clarify this. We demonstrated was significantly upregulated transforming growth factor beta 1 (TGF‐β1)‐treated through ELK1 transcriptional activation, highly...
Protein phosphatase 2A (PP2A) is very versatile owing to a large number of regulatory subunits and its ability interact with numerous other proteins. The A subunit exists as two closely related isoforms designated Aα Aβ. Mutations have been found in both variety human cancers. Although has intensely studied, little known about We generated Aβ-specific antibodies determined the cell cycle expression, subcellular distribution, metabolic stability Aβ comparison Aα. Both forms were expressed at...
Abstract Epidermal growth factor receptor (EGFR) plays a critical role in mediating ultraviolet (UV) irradiation‐induced signal transduction and gene expression human keratinocytes. EGFR activation results from increased phosphorylation on specific tyrosine residues the C‐terminal intracellular domain. It has recently been reported that following stimulation translocates surface membrane to nucleus, where it may directly regulate transcription. We have investigated ability of UV irradiation...
Abstract Background The regulation of protein phosphorylation requires a balance in the activity kinases and phosphatases. Our previous data indicates that Src can increase ERK through Raf kinase response to ischemic stimuli. This study examined molecular mechanisms by which activates cascade phosphatases following cerebral ischemia. Results Ischemia-induced activation is followed PP2A at Tyr307 leading its inhibition rat hippocampus. SU6656, inhibitor, up-regulates activity, resulting...
// Qi Zhang 1, * , Ce Shi 6, Lina Han 6 Nitin Jain 1 Kathryn G. Roberts 2 Helen Ma Tianyu Cai Antonio Cavazos Yoko Tabe 3 Rodrigo O. Jacamo Hong Mu Yang Zhao 4 Jing Wang Shuo-Chieh Wu 5 Fenglin Cao Zhihong Zeng Jin Zhou Yingchang Mi 7 Elias J. Jabbour Ross Levine 8 Sarah K. Tasian 9 Charles Mullighan David M. Weinstock A. Fruman 10 and Marina Konopleva Department of Leukemia, The University Texas M.D. Anderson Cancer Center, Houston, TX, USA Pathology, St. Jude Children's Research Hospital,...
Quercetin is able to inhibit proliferation of malignant tumor cells; however, the exact mechanism involved in this biological process remains unclear. The current study utilized a quantitative proteomic analysis explore antitumor mechanisms quercetin. leucine HepG2 cells treated with quercetin was labeled as d3 by stable isotope labeling amino acids cell culture (SILAC). peaks control were compared d3-labeled mass spectrometry (MS) identify significantly altered proteins. Reverse...
Herein, we report a case of occult epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma complicated by prostatic metastasis. A 75-year-old male with >30 years smoking history presented lower back pain as the initial symptom. Respiratory symptoms, including cough and sputum production, were absent. PET–computed tomography revealed presence bone metastases, without any abnormalities. Biopsies space-occupying metastatic lesions suggested that metastases originated from primary...
Cancer-associated weight loss occurs frequently in patients with advanced lung cancer. Many studies have demonstrated that tumor-derived exosomes could mediate the interplay between tumor cells and distal organs. In this study, we explored interaction cancer cell-derived (LCCDEs) niche of intestinal stem (ISCs). Lewis carcinoma-1 (LLC1)-conditional medium (LLC1-CM), N,N'-Bis[5-(2,3-dihydro-1H-indol-1-yl)pentyl]-1,6-hexanediamine (GW4869)-conditional (GW4869-CM), LCCDEs phosphate-buffered...
Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients. These include exon 14 skipping mutations (MET skipping), amplifications, point (primarily kinase domain mutations), and protein overexpression. Accurate identification these appropriate selection patient populations targeted...
Chimeric antigen receptor-modified T cell (CART) therapy has been demonstrated to have significant effect on hematologic tumor in patients. However, many persistent obstacles and challenges still limit the application. It is known that CD8 cells are a key component of antitumor immunity. An avasimibe-induced inhibition cholesterol esterification shown improve response mice. In this study, using human CD19-directed CART as effector CD19-overexpressing K562 target cells, we detected whether...
Ice is omnipresent in our daily life and possesses intrinsic slipperiness as a result of the formation quasi-liquid layer. Thus, functional surfaces inspired by ice show great prospects widespread fields from surface lubrication to antifouling coatings. Herein, we report an ice-inspired polymeric slippery (II-PSS) constructed self-lubricating liquid layer densely surface-grafted polymer brush. The brush could act homogeneous matrix capture lubricant molecules via strong dynamic dipole–dipole...
Malignant pleural mesothelioma (MPM) is a malignant tumor originating from the pleura, and its incidence has been increasing in recent years. Due to insidious onset strong local invasiveness of MPM, most patients are diagnosed late stage early screening treatment for high-risk populations crucial. The MPM mainly includes surgery, chemotherapy, radiotherapy. Immunotherapy electric field therapy have also applied, leading further improvements patient survival. Mesothelioma Group Yangtze River...
The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell-surface molecules responsible for transmitting signals that regulate cell growth differentiation. In non-small lung cancer (NSCLC), RET fusion a rare driver alteration associated with poor prognosis. Fortunately, two selective inhibitors (sRETi), namely pralsetinib selpercatinib, have been approved treating NSCLC due to their remarkable efficacy safety profiles. These shown ability overcome...
Abstract The fusion genes NRG1 and NRG2, members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, retains its EGF-like active domain, binds to ERBB ligand triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. incidence gene varies across cancer types, with lung being most prevalent at 0.19 0.27%. CD74 SLC3A2 are frequently observed partners. RNA-based next-generation sequencing is primary method for...
5551 Background: RC88 is a first-in-class, antibody-drug conjugate (ADC) targeting mesothelin (MSLN) with the payload of Monomethyl auristatin E. MSLN, glycosylphosphatidylinositol-anchored protein, overexpressed in several solid tumors limited expression normal tissues. RC88-C001 single-arm, open-label, multi-center phase 1/2 study evaluating patients (pts) MSLN-expressing advanced tumor (NCT04175847). This abstract mainly reports efficacy results from dose expansion part (phase 2) study....
Objective: Necrotizing enterocolitis (NEC) is a gastrointestinal emergency with severe inflammation storm, intestinal necrosis, and perforation. MicroRNA-146a-5p (miR-146a-5p) has been reported to be valuable anti-inflammatory factor in various inflammatory disorders. However, the role of miR-146a-5p NEC, its effects on nucleotide-binding domain leucine-rich repeat-containing protein 3 (NLRP3) inflammasome, downstream factors remain unknown. This study aimed investigate NLRP3 inflammasome...
Abstract Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation migration, survival. Its alterations, mainly including mutations, amplifications, overexpression are associated with poor prognosis one of the major drivers non–small lung cancer (NSCLC). Several clinical trials had been investigating on treatments HER2‐altered NSCLC, conventional chemotherapy, programmed death 1 (PD‐1) inhibitors, inhibitors (TKIs)...