A5101929506- Gut microbiota and health
- Spine and Intervertebral Disc Pathology
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Musculoskeletal pain and rehabilitation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Beetle Biology and Toxicology Studies
- Gastrointestinal disorders and treatments
- Pharmacological Effects of Natural Compounds
- Animal Virus Infections Studies
- Nitric Oxide and Endothelin Effects
- Viral gastroenteritis research and epidemiology
- Cancer Mechanisms and Therapy
- Natural Compounds in Disease Treatment
- Cancer Cells and Metastasis
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Liver Disease and Transplantation
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
Southern University of Science and Technology
2024-2025
First Affiliated Hospital of Zhengzhou University
2025
Harbin Medical University
2013-2023
First Affiliated Hospital of Harbin Medical University
2016-2023
Soochow University
2023
Weatherford College
2022
Patients First
2022
State Key Laboratory of Natural Medicine
2021
China Pharmaceutical University
2020-2021
Qingdao University
2021
Background: Hashimoto's thyroiditis (HT) is an organ-specific autoimmune disease in which both genetic predisposition and environmental factors serve as triggers. Many studies have indicated that alterations the gut microbiota are important development of inflammatory diseases. A comparative analysis was systematically performed HT patients healthy controls. Methods: First, a cross-sectional study 28 16 matched controls conducted. Fecal samples were collected, analyzed using 16S ribosomal...
Background and Aims Itaconate, a metabolite of the tricarboxylic acid cycle, plays anti‐inflammatory roles in macrophages during endotoxemia. The mechanisms underlying its have been shown to be mediated by modulation oxidative stress, an important mechanism hepatic ischemia–reperfusion (I/R) injury. However, role itaconate liver I/R injury is unknown. Approach Results We found that deletion immune‐responsive gene 1 (IRG1), encoding for enzyme producing itaconate, exacerbated systemic...
The aim of our study was to investigate the relationship among gut microbiota community, metabolite profiles and thyroid carcinoma (TC). First, 30 TC patients 35 healthy controls (HCs) fecal samples were applied characterize microbial community using 16S rRNA gene sequencing. Differential compositions observed, with significant enrichment 19 depletion 8 genera in compared those HCs ( Q value <0.05), some correlated various clinical parameters, such as lipoprotein A apolipoprotein B....
Liver ischemia-reperfusion (I/R) injury occurs through induction of oxidative stress and release damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or the nucleus. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a sensor known to trigger stimulator interferon genes (STING) downstream type 1 (IFN-I) pathways, which are pivotal innate immune system responses pathogen. However, little about role...
We report the construction of chimeric coxsackievirus B3 (CVB3) strains in which sequences an infectious cDNA copy a noncardiovirulent CVB3 genome were replaced by homologous from cardiovirulent to identify 10 predicted genetic sites determine cardiovirulence. Cardiovirulent phenotype expression was consistently linked nucleotide 234 (U and C avirulent CVB3) 5' nontranslated region. Reconstructions parental chimeras restored when tested mice. Inoculation severe combined immunodeficient...
Cholangiocarcinoma (CCA) is a malignant tumor that resistant to chemotherapy, so new therapeutic agents are needed. Allicin which rapidly converted from allin by allinase, one of the most biologically active compounds in freshly crushed garlic and has been shown have strong anti-tumor effects. Our aim was explore molecular mechanism allicin affects cell proliferation invasion CCA.Cell viability apoptosis were measured using CCK-8 assay, colony formation flow cytometry. Cell migration...
Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity...
A critical obstacle in advanced colorectal cancer (CRC) treatment is the insufficient improvement on survival of conventional chemotherapy. Cancer stem cells are reported to be one crucial explanations. CD133 has been identified as a surface marker CRC cells. Bispecific antibodies (BiAbs) targeting tumor-specific antigens promising therapeutics for malignant diseases, yet that produced by genetic engineering not published. In current research, expression primary was detected...
Dysbiosis of gut microbiota and metabolome is a frequently encountered condition in liver cirrhosis (LC) patients. The severity dysfunction was found to be correlated with the degree microbial dysbiosis. Several clinical studies have indicated function improvement after therapeutic splenectomy for LC induced hypersplenism. We sought determine whether such post-splenectomy outcome pertinent modulation abnormal microenvironment A cross-sectional study including 12 patients 16 healthy...
Thymic stromal lymphopoietin (TSLP) is a cytokine mainly released by epithelial cells that plays important roles in inflammation, autoimmune disease, and cancer. While TSLP expressed the liver at high levels, role of ischemia/reperfusion (I/R) injury remains unknown. Experiments were carried out to determine I/R injury. Wild-type (WT) receptor–knockout (TSLPR–/–) mice subjected partial warm Liver was assessed measuring serum alanine aminotransferase (ALT) level, necrotic areas histology,...
Abstract Y-box binding protein 1 (YBX1) is involved in the development of multiple types tumors. However, relationship between YBX1 and autophagy non-small cell lung cancer (NSCLC) remains unclear. In this study, we analyzed expression clinical significance markers (LC3I/II) NSCLC examined their roles regulating sensitivity to cisplatin NSCLC. The retrospective analysis patients with indicated that was positively correlated autophagy. Increased levels or also observed cells compared those...
Abstract Aging is a pivotal risk factor for intervertebral disc degeneration (IVDD) and chronic low back pain (LBP). The restoration of aging nucleus pulposus cells (NPCs) to youthful epigenetic state crucial IVDD treatment, but remains formidable challenge. Here, we proposed strategy partially reprogram reinstate epigenetics senescent NPCs by delivering plasmid carrier that expressed pluripotency-associated genes ( Oct4 , Klf4 Sox2 ) in Cavin2-modified exosomes (OKS@M-Exo) treatment...
Chimeric antigen receptor-modified T cell (CART) therapy has been demonstrated to have significant effect on hematologic tumor in patients. However, many persistent obstacles and challenges still limit the application. It is known that CD8 cells are a key component of antitumor immunity. An avasimibe-induced inhibition cholesterol esterification shown improve response mice. In this study, using human CD19-directed CART as effector CD19-overexpressing K562 target cells, we detected whether...
Disturbance of the gut microbiota is common in liver cirrhosis (LC) patients, underlying mechanisms which are yet to be unfolded. This study aims explore relationship between small bowel transit (SBT) and LC patients. Cross-sectional design was applied with 36 patients 20 healthy controls (HCs). The characterized by 16S rRNA gene sequencing. Firmicutes/Bacteroidetes (F/B) ratio Microbial Dysbiosis index (MDI) were used evaluate severity dysbiosis. scintigraphy method performed describe...
Summary Colorectal cancer (CRC) is a common disease worldwide that strongly associated with the gut microbiota. However, little known regarding microbiota after surgical treatment. 16S rRNA gene sequencing was used to evaluate differences in among colorectal adenoma patients, CRC postoperative patients and healthy controls by comparing diversity, overall composition taxonomic signature abundance. The of developed accordance adenoma‐carcinoma sequence, impressive shifts before or during...
Background: Drugs can alter the gut microbiota structure, and dysbiosis in turn is correlated with drug side effects through intestinal endotoxemia hypothesis. Whether antithyroid drugs (including methimazole propylthiouracil) cause whether induced liver injury unknown. Methods: Initial Graves’ disease patients were randomly divided into group ( n = 20) propylthiouracil followed up every 2 weeks; 50 healthy controls also included. The structure function of compared from cross sectional...
Renal fibrosis is the final common pathological manifestation of almost all progressive chronic kidney diseases (CKD). Transient receptor potential canonical (TRPC) channels, especially TRPC3/6, were proposed to be essential therapeutic targets for injury. Huangkui capsule (HKC), an important adjuvant therapy CKD, showed superior efficacy CKD at stages 1-2 in clinical practice. However, its anti-fibrotic effect and underlying mechanisms remain investigated. In present study, we evaluated HKC...
Heterologous expression of a transcription factor (TF) gene in related species is useful method for crop breeding and the identification function. The differences phenotype target between HE lines (with heterologous an ortholog) OX overexpressed native gene) must be understood. EsNAC1, encoding NAC protein ortholog RD26 Arabidopsis, was cloned from Eutrema salsugineum introduced into Arabidopsis. EsNAC1 retarded vegetative growth transgenic plants (HE lines) showed much greater resistance to...
Splenectomy carries a long-term risk of postoperative infection, and the chronic, low-grade inflammation associated with endotoxemia may be related to gut microbiota. In this study, increase our understanding potential cause high rate infection in postsplenectomy patients, we evaluated differences microbiota plasma lipopolysaccharide level patients after splenectomy relative those healthy controls. Thirty-two having undergone 42 individuals were enrolled into (SP) control (HC) groups,...