A5100375808- Cancer Cells and Metastasis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Renal cell carcinoma treatment
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Berberine and alkaloids research
- Urological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Renal and related cancers
- Urologic and reproductive health conditions
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Melanoma and MAPK Pathways
- Metastasis and carcinoma case studies
Binzhou University
2025
Binzhou Medical University
2025
The Second Nanning People's Hospital
2024
Second Hospital of Anhui Medical University
2015-2024
Anhui Medical University
2015-2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Anhui Provincial Children's Hospital
2024
Xian Yang Central Hospital
2024
Tongji Hospital
2023
Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered a paucity specific markers for identification isolation normal malignant colon. Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as possible marker identifying colonic tracking them during progression....
Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the Snail metastasis ovarian carcinoma, expression was knocked down by antisense-Snail highly metastatic cell line HO8910PM. Gene array analysis revealed that blocking suppressed activity matrix metalloproteinases (MMPs) and upregulated TIMP3, MMP inhibitor. These findings suggest interacts with during tumor invasion In addition, we examined orthotopic model...
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior early systemic metastasis. The survival rates for osteosarcoma remain unchanged over past two decades. Studies aiming to find new or alternative therapies patients refractory are urgently needed. Anlotinib, a novel multi‐targeted tyrosine kinase inhibitor (TKI), has exhibited encouraging clinical activity NSLCC soft tissue sarcoma, whereas its effect on not been studied....
Circulating tumor cells (CTCs) detected in peripheral blood (PB) of cancer patients can be identified as isolated CTCs and circulating microemboli (CTM). This study aimed to evaluate the prognostic value CTM detection CTC phenotype advanced colorectal (CRC) during chemotherapy.A size-based platform for isolation was applied. PB samples (5 ml) from 98 CRC 2-6 cycles chemotherapy were collected detection, count correlated patient's clinicopathological characteristics clinical outcome. And...
This study aimed to evaluate the clinical efficacy of percutaneous vertebroplasty (PVP) performed with a two-step fluoroscopy technique for treating thoracic osteoporotic vertebral compression fractures (OVCFs) in older patients. A retrospective analysis was conducted on and imaging data from 48 patients diagnosed OVCFs, who underwent treatment vertebroplasty(PVP) utilizing at Yangquan First People's Hospital between January 2019 2022. The assessed this procedure by analyzing Visual Analog...
Cervical cancer is the fourth leading cause of mortality among gynecological malignancies. However, identification cervical stem cells remains unclear.We performed single-cell mRNA sequencing on ∼122,400 from 20 biopsies, including 5 healthy controls, 4 high-grade intraepithelial neoplasias, microinvasive carcinomas cervix, and 6 invasive squamous carcinomas. Bioinformatic results were validated by multiplex immunohistochemistry (mIHC) in tissue microarrays (TMA) (n = 85).We identified...
Abstract Purpose: We sought to examine the synergistic antipancreatic cancer effect by simultaneously targeting hypoxic cells with heat-shock protein 90 (HSP90) inhibitor and blockade of energy production. Experimental Design: The anticancer effects an HSP90 (geldanamycin) in pancreatic were investigated hypoxia normoxia. A hexokinase II inhibitor, 3-broma-pyruvate (3BrPA), was evaluated for selective glycolysis inhibition as a sensitizer against cancer. client degradation monitored Western...
A critical obstacle in advanced colorectal cancer (CRC) treatment is the insufficient improvement on survival of conventional chemotherapy. Cancer stem cells are reported to be one crucial explanations. CD133 has been identified as a surface marker CRC cells. Bispecific antibodies (BiAbs) targeting tumor-specific antigens promising therapeutics for malignant diseases, yet that produced by genetic engineering not published. In current research, expression primary was detected...
Abstract In clinical practice, renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney (AKI), often leading to failure or end-stage disease (ESRD). The current understanding IRI mechanisms remains unclear, and effective therapeutic strategies clear targets are lacking. Therefore, the need find explicit ways reduce scientific challenge. study explored pyroptosis, type inflammation-regulated programmed cell death, role Gasdermins E (GSDME)-mediated mitochondrial damage,...
It was believed that tumors originated from the transformation of their tissue-specific stem cells. However, bone marrow-derived cells (BMDCs), which possess an unexpected degree plasticity and often reside in other tissues, might also represent a potential source malignancy. To study whether BMDCs play role tumors, mice were treated with 3-methycholanthrene until malignant achieved. Here we show transformed could form many tumor types, including epithelial neural muscular fibroblasts, blood...
PURPOSE: Gastric cancer studies indicated a potential correlation between circulating tumor cells (CTCs) in peripheral blood and relapse/metastasis. The prevalence significance of microemboli (CTM) gastric remain unknown. We investigated the prognostic value CTCs CTM for progression-free survival (PFS) overall (OS) patients. METHODS:Eighty-one patients consented to provide 5 ml before systematic therapy. were isolated using isolation by size epithelial characterized cytopathologists. For 41...
Progression of many cancers is associated with tumor infiltration by mesenchymal stromal cells (MSC). Adipose (ASC) are MSC that serve as adipocyte progenitors and endothelium-supporting in white adipose tissue (WAT). Clinical animal model studies indicate ASC mobilized from WAT recruited tumors. Direct evidence for function microenvironment has been lacking due to unavailability approaches specifically inactivate these cells. Here, we investigate the effects a proteolysis-resistant targeted...
BACKGROUND:Hyperglycemia is one of the most dangerous factors causing diabetic nephropathy. Salidroside considered to have effects reducing oxidative stress damage and improving cell viability. This study was performed investigate whether how salidroside reduces high-glucose (HG)-induced apoptosis in mouse podocytes. MATERIAL AND METHODS:We examined could decrease HG-induced podocyte vitro. The potential signaling pathways were also investigated. Podocytes (immortalized epithelial cells)...
This study aimed to validate the clinical feasibility, safety, and effectiveness of using fluorescence endoscopy with second window indocyanine green (FESWICG) technique for resection malignant brain tumors. Twenty-two patients undergoing surgery tumor were examined. Intravenous ICG (250 mg) was administered within 24 hours prior surgery. All procedures performed under endoscopic guidance. The intensity tumors monitored mode endoscopy. Specimens including margins harvested submitted...
// Shirin R. Modarai 1, 2 , Anindita Gupta Lynn M. Opdenaker Ryan Kowash 2, 3 Gabriel Masters 4 Vignesh Viswanathan Tao Zhang 5, 6 Jeremy Z. Fields 7 and Bruce Boman 5 1 Department of Biological Sciences, University Delaware, Newark, DE, USA Center for Translational Cancer Research, Helen F. Graham Research Institute, Christiana Care Health System, Dickinson College, Carlisle, PA, Biochemistry Department, Hamilton Clinton, NY, Genetic Preventive Medicine, Thomas Jefferson University,...