A5010715759- EEG and Brain-Computer Interfaces
- Cancer-related molecular mechanisms research
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Ion channel regulation and function
- Renal Diseases and Glomerulopathies
- Neuroscience and Neural Engineering
- Suicide and Self-Harm Studies
- Sleep and related disorders
- Animal Disease Management and Epidemiology
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Inflammatory Bowel Disease
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Genetic Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Ion Channels and Receptors
- Venomous Animal Envenomation and Studies
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
China Pharmaceutical University
2020-2025
First Affiliated Hospital Zhejiang University
2025
Wenzhou Medical University
2022-2024
First Affiliated Hospital of Wenzhou Medical University
2024
Xinjiang Academy of Agricultural Sciences
2024
Xinjiang University
2024
Ministry of Agriculture and Rural Affairs
2024
Bengbu Medical College
2021-2023
State Key Laboratory of Natural Medicine
2020-2023
China Medical University
2015-2023
Abstract The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) the average size 50–100 nm was synthesized incorporation TA into framework MSN. It further adsorbed indocyanine green (ICG) by electrostatic attraction to render MSN‐TA‐ICG as an efficient NIR contrast agent imaging. studies stability against pH indicated bonding stable over range from...
Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with unmet clinical needs. As a ingredient found in several medicinal herbs efficacy on diseases, Scutellarein (Scu) has been shown to possess anti-inflammatory and anti-proliferative activities. We aimed evaluate therapeutic Scu against AD its underlying molecular mechanism.Efficacy was evaluated 2,4-dinitrofluorobenzene (DNFB) carvacrol-induced mouse models. Cytokine mRNA serum IgE levels were examined...
Background and Purpose Genetic ablation or inhibition of the cation channel TRPC6 is protective against renal, cardiac intestinal fibrosis. However, expression decreased in patients with liver diseases. Here, we explored role fibrosis underlying mechanism. Experimental Approach Bile duct ligation thioacetamide gavage were used to model C57BL/6J mice. Western blotting, immunolabelling qPCR employed for protein mRNA expression. Liver injury/fibrosis assessed using serum alanine transaminase...
Lethal autophagy is a pathway leading to neuronal death caused by transient global ischemia. In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/reperfusion-induced autophagic and investigated role PI3K/Akt. Ischemic in vitro was induced using oxygen glucose deprivation (OGD) SH-SY5Y cells, ischemia produced two vessels occlusion rats. Cellular viability cells assessed MTT assay, CA1 evaluated Hematoxylin-eosin staining. Autophagic vacuoles were detected both...
Intracranial electroencephalographic (iEEG) signals from two human subjects were used to achieve simultaneous neural control of reaching and grasping movements with the Johns Hopkins University Applied Physics Lab (JHU/APL) Modular Prosthetic Limb (MPL), a dexterous robotic prosthetic arm. We performed functional mapping high gamma activity while subject made identify task-selective electrodes. Independent, online was then achieved using small subset electrodes model trained on short blocks...
Abstract Background The rapidly increasing case reports revealed that neuronal intranuclear inclusion disease (NIID) had concomitant other system symptoms besides nervous symptoms. In this study, we systematically evaluated the symptoms, signs, auxiliary examination, and pathological changes in different systems NIID patients. Methods patients were confirmed by examining GGC repeats NOTCH2NLC gene. Clinical data of including examinations collected for analysis. Ubiquitin p62 detected tissues...
<h3>Objective:</h3> To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) language cortex in patients being monitored epilepsy surgery. <h3>Methods:</h3> We developed tested an system that exploits ECoG9s temporal resolution to display evolution statistically significant high gamma (70–110 Hz) responses across all recording sites activated by a discrete cognitive task. illustrate how this can be...
Although survival rate of infants born prematurely has been raised by supplemental oxygen treatment, it is followed high morbidity hyperoxia-induced bronchopulmonary dysplasia. In this study, the effect resveratrol on lung injury was evaluated in hyperoxia-exposed rats preterm birth. The results demonstrated that hyperoxia led to thickened alveolar wall, simplified architecture and fibrosis. addition, elevated methane dicarboxylic aldehyde level, decreased glutathione level superoxide...
Suicide is an important global public health issue, which deserves more attention. This study aims to examine the relative independent relationship between suicide ideation and subjective sleep quality, hygiene, insomnia symptoms in undergraduate students China. population-based included 2379 aged 18-26, randomly recruited from three universities Shanghai. The participants completed four questionnaires: Pittsburgh Sleep Quality Index; Hygiene Practice Scale; Insomnia Severity Symptom...
Functional human brain mapping is commonly performed during invasive monitoring with intracranial electroencephalographic (iEEG) electrodes prior to resective surgery for drug- resistant epilepsy. The current gold standard, electrocortical stimulation (ESM), time -consuming, sometimes elicits pain, and often induces after discharges or seizures. Moreover, there a risk of overestimating eloquent areas due propagation the effects broader network language cortex. Passive iEEG spatial-temporal...
<b><i>Background:</i></b> Radiation therapy is a mainstay in the treatment of cervical cancer. However, most advanced and metastatic cancers are resistant to radiation because presence cancer stem cells (CSCs). To date, no specific markers were found for CSCs. <b><i>Methods:</i></b> The fraction CD44<sup>+</sup>/CD24<sup>+</sup> cell subpopulation was detected with flow cytometry (FCM). clonogenicity radiosensitivity...
Renal fibrosis is the final common pathological manifestation of almost all progressive chronic kidney diseases (CKD). Transient receptor potential canonical (TRPC) channels, especially TRPC3/6, were proposed to be essential therapeutic targets for injury. Huangkui capsule (HKC), an important adjuvant therapy CKD, showed superior efficacy CKD at stages 1-2 in clinical practice. However, its anti-fibrotic effect and underlying mechanisms remain investigated. In present study, we evaluated HKC...
Neuropathic pain is a widespread health problem with limited curative treatment. Decreased sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) expression has been reported in dorsal root ganglion (DRG) of animals suffering from neuropathic pain. We aimed to establish the relationship between SERCA and responses elucidate underlying molecular mechanism.Neuropathic was modelled using rat chronic constriction injury (CCI). imaging current clamp patch-clamp were used determine cytosolic levels...
Idiopathic congenital nystagmus (ICN) is a common oculomotor disorder characterized by bilateral involuntary, periodic, and predominantly ocular oscillations. X-linked ICN (XLICN) with incomplete penetrance in females the most inheritance form, FERM domain containing (FRMD7) mutation major reason for XLICN families. To date, 39 FRMD7 mutations have been identified, 50% of pedigrees yielded Western population. In this study, we identified novel frameshift (c.1274–1275delTG) gene six...
Neural keyword spotting could form the basis of a speech brain-computer-interface for menu-navigation if it can be done with low latency and high specificity comparable to "wake-word" functionality modern voice-activated AI assistant technologies. This study investigated neural using motor representations via invasively recorded electrocorticographic signals as proof-of-concept. matched filters were created from monosyllabic consonant-vowel utterances: one utterance, eleven similar...