A5026848585- Medical Research and Treatments
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Cancer Research and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Cancer-related molecular mechanisms research
- Ocular Surface and Contact Lens
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Retinal Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Hepatitis B Virus Studies
- Inflammation biomarkers and pathways
- Neurological Disorders and Treatments
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Ophthalmology and Visual Impairment Studies
- Galectins and Cancer Biology
- Atherosclerosis and Cardiovascular Diseases
- Retinal Development and Disorders
Ministry of Agriculture and Rural Affairs
2022-2025
Hubei Academy of Agricultural Sciences
2017-2025
Animal Science Research Institute
2017-2025
Taixing People's Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2025
Eye & ENT Hospital of Fudan University
1999-2025
Liaocheng People's Hospital
2014-2025
Shandong First Medical University
2025
Peking Union Medical College Hospital
2017-2025
First Hospital of Jilin University
2025
Dengue virus (DENV), a mosquito-borne flavivirus, is major public health threat. The poses risk to 2.5 billion people worldwide and causes 50 100 million human infections each year. Neither vaccine nor an antiviral therapy currently available for prevention treatment of DENV infection. Here, we report previously undescribed adenosine analog, NITD008, that potently inhibits both in vitro vivo. In addition the 4 serotypes DENV, NITD008 other flaviviruses, including West Nile virus, yellow...
Abstract Lychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar ‘Feizixiao’ was assembled into 15 pseudochromosomes, totaling ~470 Mb. High heterozygosity (2.27%) resulted in two complete haplotypic assemblies. A total 13,517 allelic genes (42.4%) were differentially expressed diverse tissues. Analyses 72 resequenced lychee accessions revealed independent domestication events. extremely early maturing cultivars preferentially aligned to one haplotype domesticated...
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that potently inhibits DENV both vitro and vivo. inhibitor was identified through screening 1.8-million-compound library by using DENV-2 replicon assay. selectively -3 (50% effective concentration [EC50], 10 80 nM) but not DENV-1 -4 (EC50,>20 M)....
We observed and analyzed the morphologic characteristics of polypoidal lesions abnormal branching vascular network (BVN) in patients with choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA).A retrospective observational case series was done PCV. All were scanned a 70-kHz spectral-domain OCT system using split-spectrum amplitude-decorrelation (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images these compared those indocyanine green...
The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier (NLC) drug delivery platform. An ophthalmic anti-inflammatory drug, baicalin (BN) chosen as the model drug. BN NLC prepared using melt-emulsification combined with ultra-sonication technique. Additionally, dual pH- and thermo-sensitive hydrogel composed carboxymethyl chitosan (CMCS) poloxamer 407 (F127) fabricated by cross-linking reaction nontoxic crosslinker...
To investigate the diagnostic efficiency and prognostic value of 68Ga-Pentixafor PET/CT in comparison with adrenal vein sampling (AVS) for functional lateralization primary aldosteronism (PA). Histology long-term clinical follow-up normally serve as gold standard such diagnosis. We prospectively recruited 26 patients diagnosed PA. All underwent AVS. Postsurgical biochemical outcomes unilateral (UPA), by or AVS, were assessed applying standardized Primary Aldosteronism Surgical Outcome (PASO)...
Abstract Background Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia (EP), a mild, chronic swine. Despite presenting with low direct mortality, EP responsible for major economic losses in pig industry. To identify virulence-associated determinants M. , we determined whole genome sequence strain 168 and its attenuated high-passage 168-L carried out comparative genomic analyses. Results We performed first comprehensive analysis hyopneumonia e made preliminary...
Significance Obesity has become a major epidemic around the globe, with fatal comorbidities such as type 2 diabetes, heart disease, and cancer that have led to alarming health concerns in modern medicine. Although excess adipose tissue is associated negative metabolic outcomes, physiological functions of epigenetic regulators metabolism are unclear. Here we show KDM4B tissues epigenetically controls energy expenditure, oxidation, lipolysis, thermogenesis. Loss Kdm4b impairs adaptive...
Duchenne muscular dystrophy (DMD) is caused by the absence of cytoskeletal protein, dystrophin. In DMD patients, dilated cardiomyopathy leading to heart failure may occur during adolescence. However, early cardiac dysfunction frequently undetected due physical inactivity and generalized debilitation. The objective this study determine time course functional alterations in mdx mouse, a mouse model DMD, evaluating regional ventricular function with CMR tagging. vivo myocardial was evaluated 3D...
Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by spasticity the lower limbs due to pyramidal tract dysfunction. Here, we report that missense homozygous mutation c.424G>T (p.D142Y) in FARS2 gene, which encodes mitochondrial phenylalanyl tRNA synthetase (mtPheRS), causes HSP Chinese consanguineous family using combination mapping whole-exome sequencing. Immunohistochemical experiments were performed showing...
Improving the robustness of fish stock has become a key issue in advancement aquaculture, as diseases and harsh aquatic conditions impact industry sustainability yield. In this study, we identify several genetic loci that link swimming performance to disease resistance large yellow croaker, apply genomic selection (GS) for generate offspring with both enhanced resistance. First, classified our reference population superior swimmers (SS) or inferior (IS) by tests assessed inherent Consistent...
Volumetric, high-resolution, quantitative mapping of brain-tissue relaxation properties is hindered by long acquisition times and SNR challenges. This study combines time-efficient wave-controlled aliasing in parallel imaging (wave-CAIPI) readouts with the 3D quantification using an interleaved Look-Locker sequence a T2 preparation pulse (3D-QALAS), enabling full-brain T1 , proton density (PD) maps at 1.15-mm3 isotropic voxels 3 min.Wave-CAIPI were embedded standard 3D-QALAS encoding scheme,...
Abstract Background Breast cancer (BC) is a heterogeneous disease, with the ductal subtype exhibiting significant cellular diversity that influences prognosis and response to treatment. Single-cell RNA sequencing data from GEO database were utilized in this study investigate underlying mechanisms of heterogeneity identify potential prognostic markers therapeutic targets. Methods Bioinformatics analysis was conducted using R packages analyze single-cell data. The presence highly variable...
We introduce a novel meshless simulation method for the McKean-Vlasov Stochastic Differential Equation (MV-SDE) utilizing deep learning, applicable to both self-interaction and interaction scenarios. Traditionally, numerical methods this equation rely on interacting particle combined with techniques based It\^o-Taylor expansion. The convergence rate of approach is determined by two parameters: number particles $N$ time step size $h$ each Euler iteration. However, extended horizons or...
The influence of alternating current (AC) field on the pack boriding process for medium carbon steel was investigated through characterization microstructure, phase composition, microhardness, and corrosion resistance boride layer its mechanism revealed. Results showed that obtained by AC composed outer FeB inner Fe2B phase, which similar to conventional boriding. Meanwhile, effective thickness proportion increased gradually with increasing during introduction an served dual purposes. First,...
A machine vision-based weld seam positioning system for thermos cups is proposed. The system’s operational flow and image algorithms are designed to achieve automatic calibration of the orientation. Experimental results show a qualification rate 97.8%, demonstrating robust performance across various cup models. average error 45 pixels, with maximum 153 corresponding angular deviations 0.68° 2.30°, respectively. processing time single algorithm run 128 ms, ensuring efficient operation in...