A5103269472- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
- Circular RNAs in diseases
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- COVID-19 and Mental Health
- Stress Responses and Cortisol
- COVID-19 epidemiological studies
- Epigenetics and DNA Methylation
- Disaster Response and Management
- Renal cell carcinoma treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Gastrointestinal Tumor Research and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
First Affiliated Hospital Zhejiang University
2023-2025
Central South University
2025
Hunan Cancer Hospital
2025
Wenzhou Medical University
2023-2024
Zhoushan Hospital
2023-2024
Abstract Background Near 70% of hepatocellular carcinoma (HCC) recurrence is early within 2-year post surgery. Long non-coding RNAs (lncRNAs) are intensively involved in HCC progression and serve as biomarkers for prognosis. The aim this study to construct a lncRNA-based signature predicting recurrence. Methods Data RNA expression associated clinical information were accessed from Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) database. Recurrence differentially expressed...
Objective: To investigate and analysis the epidemiological characteristics of a cluster epidemic COIVD-19 in collective workplace Tianjin, evduate prevention control measures based on limited evidence experience early period COVID-19 epidemic. Methods: Descriptive research method was used to describe distribution other cases COVID-19. Results: Since onset first index case January 15, ten confirmed had occurred workplace, spread from 4 families, infecting 7 family members. The median age 17...
The crucial role of competitive endogenous RNA (ceRNA) in the malignant biological behavior tumors has been certificated. Nevertheless, detailed function and molecular mechanism ceRNA associated with cuproptosis hepatocellular carcinoma (HCC) remains dismal. In this study, we first constructed a protein–protein interaction network identified module highest degree aggregation degree. DLAT PDHA1 were screened out after differential expression survival analysis. Next, reverse-predicted upstream...
Competitive endogenous RNA (ceRNA) is an innovative way of gene expression modulation, which plays a crucial part in neoplasia. However, the intricacy and behavioral characteristics ceRNA network hepatocellular carcinoma (HCC) remain dismal.
PDHA1 was associated with metabolic reprogramming in tumor progression. However, the clinical value of PDHA1, especially for prediction drug sensitivity hepatocellular carcinoma (HCC), has not been fully investigated. In this study, we found that expression higher HCC tissues compared to normal and correlated poor prognosis patients. mainly positively immune cell infiltration using TIMER, XCell, MCPCOUNTER, CIBERSORT, EPIC, QUANTISEQ algorithms, which validated by single-cell RNA-sequencing...
Abstract Background Hepatocellular carcinoma (HCC), which is featured with high morbidity and mortality worldwide, a primary malignant tumor of the liver. Recently, there wealth supporting evidence revealing that NK cell-related immune traits are strongly associated development HCC, but causality between them has not been proven. Methods Two-sample Mendelian randomization (MR) study was performed to probe causal correlation HCC. Genetic variations in were extracted from recent genome-wide...