A5101973905- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- HIV, Drug Use, Sexual Risk
- Immunotherapy and Immune Responses
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Adolescent Sexual and Reproductive Health
- Cancer Immunotherapy and Biomarkers
- Mosquito-borne diseases and control
- Air Quality and Health Impacts
- Gut microbiota and health
- Probiotics and Fermented Foods
- Cancer-related Molecular Pathways
- Disaster Response and Management
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- Climate Change and Health Impacts
- Liver physiology and pathology
- HIV, TB, and STIs Epidemiology
Dana-Farber Cancer Institute
2025
Harvard University
2025
Peking University First Hospital
2024
Peking University
2024
East China University of Science and Technology
2024
Yangzhou University
2024
Huazhong University of Science and Technology
2010-2023
Tongji Hospital
2010-2023
First Hospital of Lanzhou University
2017-2022
Lanzhou University
2017-2022
Chimeric antigen receptor (CAR) T cell is a promising method in cancer immunotherapy but faces many challenges solid tumors. One of the major problems was immunosuppression caused by PD-1. In our study, expression c-Met GC analyzed from TCGA datasets, tissues, and lines. The CAR second-generation with 4-1BB, cMet-PD1/CD28 adding PD1/CD28 chimeric-switch (CSR). vitro, we measured changes different subgroups, phenotypes PD-1 CAR-T cells. We detected secretion levels cytokines killing ability...
Objective: To describe the epidemiological characteristics of a cluster COVID-19 cases reported in Baodi district Tianjin as 18 February, 2020, which might be associated with exposure local department store, and provide suggestions for prevention control strategy development. Methods: The basic characteristics, time area distributions, clinical manifestations, history transmission mode store were analyzed. Results: A total 40 exposure, accounting 75.47% confirmed (53 cases) district. mainly...
Spaghetti meat (SM) is a newly identified muscle abnormality that significantly affects modern broiler chickens, consequently exerting substantial economic impact on the poultry industry worldwide. However, investigations into quality and underlying causative factors of SM in broilers remain limited. Therefore, this study was undertaken to systematically evaluate fiber characteristics SM-affected meat. To elucidate disparities between normal (NO) muscles chickens reared under identical...
The beneficial effects of lactic acid bacteria are well known and recognized as functional foods that health benefits for companion animals. This study, the first time, reports probiotic properties, safety, whole-genome sequence Pediococcus acidilactici GLP06 isolated from feces beagles. In this candidate P. GLP02 were morphologically characterized tested their antimicrobial capacity, tolerance to different conditions (low pH, bile salts, an artificial gastrointestinal model, high...
Objective: To investigate and analysis the epidemiological characteristics of a cluster epidemic COIVD-19 in collective workplace Tianjin, evduate prevention control measures based on limited evidence experience early period COVID-19 epidemic. Methods: Descriptive research method was used to describe distribution other cases COVID-19. Results: Since onset first index case January 15, ten confirmed had occurred workplace, spread from 4 families, infecting 7 family members. The median age 17...
Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological was applied when identifying nine cases COVID-19 who showed persistent negative RT-PCR test results SARS-CoV-2 no symptoms COVID-19. Two were presumed to be index had cleared virus their...
Dendritic cells (DCs), as the most important antigen-presenting cells, play a crucial role in T cell activation. The latest research showed that inhibition of mammalian target rapamycin (mTOR) could enhance DCs maturation, promoting antigen presentation. Matrine has been identified one key alkaloids isolated from roots Sophora flavescens. In present study, we combined matrine and mTOR inhibitor KU0063794 to observe functions, especially presentation ability. were activated by...
Background: Accumulating evidence has revealed the importance of cancer stem cells (CSCs) in self-renewal and chemoresistance. Previous studies reported high expression ZIC2 was closely associated with tumorigenesis CSC traits. However, role as a crucial factor for regulating properties lung adenocarcinoma (LAC) remains elusive. Methods: RT-PCR WB assay were employed to assess 20 LAC tumor tissues matched non-cancerous tissues. The analyzed by evaluation CSC-related markers spheroid...
The choice of promoter regulating the selectable marker gene impacts transformation efficiency, copy number and expression flanking genes in maize. Viral or plant-derived constitutive promoters are often used to regulate genes. We compared two viral promoters, cauliflower mosaic virus (CaMV 35T) sugarcane bacilliform (SCBV) with plant rice actin1 (OsAct1) maize ubiquitin 1 (ZmUbi1) drive aryloxyalkanoate dioxygenase (aad-1) inbred line B104. ZmUbi1- OsAct1-containing constructs demonstrated...
Abstract Background Novaferon, a novel protein drug approved for the treatment of chronic hepatitis B in China, exhibits potent antiviral activities. We aimed to determine anti-SARS-CoV-2 effects Novaferon vitro, and conducted randomized, open-label, parallel group study explore COVID-19. Methods In laboratory, inhibition on viral replication cells infected with SARS-CoV-2, SARS-CoV-2 entry into healthy was determined. Antiviral were evaluated COVID-19 patients plus Lopinavir/Ritonavir, or...
Objective: To understand prevalence and transmission of transmitted drug resistance (TDR) among HIV infected men who have sex with (MSM) in Tianjin from 2014 to 2017. Methods: A total 225 blood samples were collected MSM Pol gene fragments obtained by viral RNA extraction nested PCR amplification. Phylogenetic analyses conducted. Results: 205 successfully sequenced analyzed. Based on pol sequences, 53.2% (109/205), 28.8% (59/205), 10.2% (21/205), 4.9% (10/205) 2.9% (6/205) the positive for...
The SARS-CoV-2 epidemic starting in Wuhan December, 2019 has spread rapidly throughout the nation. control measures to contain also produced influences on transport and treatment process of patients with acute myocardial infarction (AMI), adjustments management need be made at this particular time. AMI is characterized by an onset potentially fatal consequence, a short optimal window, frequent complications including respiratory infections circulatory failure, for which active on-site...
1. As a potential new drug candidate for cardiovascular protection and antitumor treatment, the physicochemical properties, gastrointestinal (GI) absorption behaviors mechanisms of S-propargyl-cysteine (SPRC) were investigated in this study.2. SPRC exhibited favorable solubility aqueous media. The log P D values low (≤1.93 ± 0.08). pKa acidic basic regions was 2.08 0.02 8.72 0.03, respectively. isoelectric point 5.40 0.02. stable rat GI fluids, showed no obvious adsorption metabolism...
1. Leonurine is a potent component of herbal medicine Herba leonuri. The detail information on leonurine metabolism in human has not been revealed so far.2. Two primary metabolites, O-glucuronide and demethylated leonurine, were observed identified pooled liver microsomes (HLMs) the predominant one.3. Among 12 recombinant UDP-glucuronosyltransferases (UGTs), UGT1A1, UGT1A8, UGT1A9, UGT1A10 showed catalyzing activity toward glucuronidation. intrinsic clearance (CLint) UGT1A1 was approximately...