A5033646176- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cerebrovascular and Carotid Artery Diseases
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Lipoproteins and Cardiovascular Health
- Tissue Engineering and Regenerative Medicine
- Atherosclerosis and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
- Atrial Fibrillation Management and Outcomes
- Kawasaki Disease and Coronary Complications
- Cardiovascular Disease and Adiposity
- Electrospun Nanofibers in Biomedical Applications
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Advanced MRI Techniques and Applications
- Mechanical Circulatory Support Devices
- Extracellular vesicles in disease
- Infective Endocarditis Diagnosis and Management
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Shanghai Clinical Research Center
2021-2024
National Clinical Research
2022-2024
National Health and Family Planning Commission
2024
Shanghai Institute of Hematology
2007-2024
PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into blood, elevates plasma low-density lipoprotein cholesterol degrading receptor. Pleiotropic effects of beyond lipid metabolism have been shown. However, direct on platelet activation thrombosis, underlying mechanisms, as well, still remain unclear.We detected agonist-induced aggregation, dense granule ATP release, integrin αIIbβ3 activation, α-granule spreading, clot retraction. These studies were...
Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiomyocytes have no regenerative capacity. Mesenchymal stem cells (MSCs) are attractive candidates for the treatment MI. The manner by which MSCs exert beneficial effect upon injured source continued study.After isolation identification exosomes from MSCs, expression miR-210 was determined...
Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial and DCM; however, its effects on mitophagy remain unexplored. The present study aimed to assess the beneficial of nicorandil DCM underlying mechanisms. Cardiac perfusion was assessed using a lectin assay, while via mt-Keima transfection transmission electron microscopy....
<b>Objective:</b> To study whether emergent intracoronary autologous bone marrow cell transplantation (BMT) is applicable for the treatment of acute myocardial infarction (AMI). <b>Methods:</b> 20 patients admitted within 24 h after onset a first AMI were randomly allocated to receive BMT (n = 10) or supernatant (controls, n immediately primary percutaneous coronary intervention. Left ventricular ejection fraction (LVEF), left end diastolic internal diameter (LVDd) and perfusion defect...
Stem cell-derived extracellular vesicles (EVs) have been demonstrated to be effective in heart repair and regeneration post infarction. However, the poor homing efficiency low yields of these therapeutics remain major obstacles before they can used clinic. To improve delivery EVs ischemia-injured myocardium, we modified mesenchymal stem cell (MSC)-derived with monocyte mimics through method membrane fusion. Monocyte mimic-bioinspired MSC-EVs (Mon-Exos) exhibited enhanced targeting injured...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) could cause virulent infection leading to Corona Virus Disease 2019 (COVID‐19)‐related pneumonia as well multiple organ injuries. Hypothesis COVID‐19 may result in cardiovascular manifestations worse clinical outcome. Methods Fifty four severe and critical patients with confirmed were enrolled. Risk factors predicting the severity of analyzed. Results Of 54 (56.1 ± 13.5 years old, 66.7% male) COVID‐19, 39...
Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus (designated as SARS-CoV-2) has become pandemic worldwide. Based on the current reports, hypertension may be associated with increased risk of sever condition in hospitalized COVID-19 patients. Angiotensin-converting enzyme 2 (ACE2) was recently identified to functional receptor SARS-CoV-2. Previous experimental data revealed ACE2 level following treatment ACE inhibitors (ACEIs) and angiotensin blockers (ARBs). Currently...
Current evidence indicates that coronary microcirculation is a key target for protecting against cardiac ischemia-reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial ([Ca2+]m) overload are underlying mechanisms involved in cardiovascular disease. Histidine triad nucleotide-binding 2 (HINT2) has been reported to modulate [Ca2+]m via the MCU complex, our previous work demonstrated HINT2 improved cardiomyocyte survival preserved heart function...
Therapeutic angiogenesis is one promising strategy for the treatment of ischemic heart disease, which leading cause death globally. In recent years, extracellular vesicles (EVs) have quickly gained much attention as a cell-free approach to stimulate angiogenesis. However, clinical applications EVs are limited by their insufficient targeting capability. Herein, we introduce method enhance therapeutic based on platelet membrane-engineered EVs.Platelet-mimetic (P-EVs) were fabricated fusing...
Ferroptosis is a newly identified form of regulated cell death that driven by iron overload and uncontrolled lipid peroxidation, but the role ferroptosis in cardiac microvascular dysfunction remains unclear. Isorhapontigenin (ISO) an analog resveratrol possesses strong antioxidant capacity cardiovascular-protective effects. Moreover, ISO has been shown to alleviate iron-induced oxidative damage peroxidation mitochondria. Therefore, current study aimed explore benefits treatment on diabetes...
Abstract Efferocytosis, mediated by the macrophage receptor MerTK (myeloid‐epithelial‐reproductive tyrosine kinase), is a significant contributor to cardiac repair after myocardial ischemia‐reperfusion (MI/R) injury. However, death of resident macrophages (main effector cells), inactivation （main receptor), and overexpression “do not eat me” signals (brake signals, such as CD47), collectively lead impediment efferocytosis in post‐MI/R heart. To date, therapeutic strategies targeting...
Despite the fact that morbidity and mortality rates significantly increase with tricuspid regurgitation (TR) severity, limited treatment options are available for treating severe TR. The single-arm, multicentre, prospective Confirmatory Clinical Study of Treating Tricuspid Regurgitation With K-Clip TM Transcatheter Annuloplasty System (TriStar) evaluated 1-year outcomes novel transcatheter annuloplasty system in secondary Between May 2022 October 2022, patients ≥severe TR despite optimal...
The optimal strategy to treat coronary bifurcation lesions (CBL) has been a long-debated topic. combination of stent in the main vessel (MV) and drug-coated balloon (DCB) side branch (SB) seems promising, but evidence is limited. This study aims investigate novel sirolimus-coated treatment non-left CBL compared with paclitaxel-coated balloon. SPACIOUS trial prospective, non-inferiority, multicentre trial. A total 230 patients were randomised sirolimus DCB or paclitaxel group 1:1 ratio....
Abstract The regenerative potential of alginate‐chitosan composite in bone and cartilage tissue has been well documented, but its utility cardiac engineering remained unknown. This study sought to determine whether early intramyocardial injection could prevent left ventricular (LV) remodeling after myocardial infarction (MI), leading a more favorable course restoration. In rat model acute MI, local hydrogel into the peri‐infarct zone preserved scar thickness, attenuated infarct expansion,...
Abstract Introduction Mesenchymal stem cells (MSCs) have potential for the treatment of myocardial infarction. However, several meta-analyses revealed that outcome cell transplantation is dissatisfactory. A series studies demonstrated combination and gene therapy was a promising strategy to enhance therapeutic efficiency. The aim this research investigate whether how overexpression hypoxia-inducible factor-1α (HIF-1α) co-transplantation mesenchymal can cardiac repair in Methods We...
Emerging evidence indicates that proinflammatory macrophage polarization imbalance plays a key role in atherosclerotic plaque progression and instability. The calcium-activated potassium channel KCa3.1 is critically involved activation function. However, the of unknown. This study investigates potential transcriptional regulation its relationship to instability.Human monocytes were differentiated into macrophages using colony-stimulating factor. Macrophages then polarized M1 cells by...
Introduction:To explore the involvement of cardiovascular system in coronavirus disease 2019 , we investigated whether myocardial injury occurred COVID-19 patients and assessed performance serum high-sensitivity cardiac Troponin I (hs-cTnI) levels predicting severity 30-day in-hospital fatality.Methods: We included 244 patients, who were admitted to Renmin Hospital Wuhan University with no preexisting or renal dysfunction.We analyzed data including patients' clinical characteristics,...