A5100369292- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Particle physics theoretical and experimental studies
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Influenza Virus Research Studies
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Breast Lesions and Carcinomas
- Viral gastroenteritis research and epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Genomics and Phylogenetic Studies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Hepatitis C virus research
- Thyroid Cancer Diagnosis and Treatment
Anhui Provincial Center for Disease Control and Prevention
2018-2025
Nanjing University of Chinese Medicine
2017-2025
Peking University
2002-2025
Renmin Hospital of Wuhan University
2025
Peking University People's Hospital
2016-2025
University of Chinese Academy of Sciences
2021-2025
Zhejiang University
2011-2025
Chinese Academy of Sciences
2013-2025
Shandong First Medical University
2025
Fourth Affiliated Hospital of Harbin Medical University
2017-2025
Large-scale genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI), but few focused on obesity as a binary trait. Here we report the results of GWAS and candidate SNP genotyping study obesity, including extremely obese cases never overweight controls well families segregating extreme thinness. We first performed 520 (BMI>35 kg/m2) 540 control subjects (BMI<25 kg/m2), measures obesity-related traits. subsequently followed up obesity-associated...
Tislelizumab, an anti-programmed cell death protein-1 antibody, was specifically engineered to minimize FcɣR macrophage binding abrogate antibody-dependent phagocytosis. Compared with chemotherapy alone, tislelizumab plus may improve clinical outcomes in patients advanced nonsquamous NSCLC (nsq-NSCLC). In this open-label phase 3 trial (RATIONALE 304; NCT03663205), histologically confirmed stage IIIB or IV nsq-NSCLC were randomized (2:1) receive either arm A: platinum (carboplatin cisplatin)...
Aumolertinib (formerly almonertinib; HS-10296) is a novel third-generation epidermal growth factor receptor tyrosine kinase inhibitor approved in China. This double-blind phase III trial evaluated the efficacy and safety of aumolertinib compared with gefitinib as first-line treatment for locally advanced or metastatic EGFR-mutated non-small-cell lung cancer (NSCLC; ClinicalTrials.gov identifier: NCT03849768).Patients at 53 sites China were randomly assigned 1:1 to receive either (110 mg)...
Background Previous studies have revealed the involvement of coffee and tea in development stroke dementia. However, little is known about association between combination risk stroke, dementia, poststroke Therefore, we aimed to investigate associations separately with developing Methods findings This prospective cohort study included 365,682 participants (50 74 years old) from UK Biobank. Participants joined 2006 2010 were followed up until 2020. We used Cox proportional hazards models...
The pathogenesis of thoracic aortic aneurysm (TAA) in Marfan syndrome (MFS) is generally attributed to vascular smooth muscle cell (VSMC) pathologies. However, the role immune cell-mediated inflammation remains elusive. Single-cell RNA sequencing identified a subset CX3CR1+ macrophages mainly located intima roots and ascending aortas Fbn1C1041G/+ mice, further validated MFS patients. Specific elimination cells by diphtheria toxin Cx3cr1-CreERT2iDTRF/+Fbn1C1041G/+ mice efficiently ameliorated...
Obesity is a highly prevalent, multigenic trait that predicts increased morbidity and mortality. Here we report results from genome scan based on 354 markers in 513 members of 92 nuclear families ascertained through extreme obesity normal body weight. The average marker interval was approximately 10 cM. We examined four correlated phenotypes, including the body-mass index (BMI) (both as quantitative discrete with threshold BMI > or /=30 kg/m2) percentage fat 40%) assessed by bioelectrical...
The epithelial-mesenchymal transition (EMT) plays an important role in breast cancer metastasis, especially the most aggressive and lethal subtype, “triple-negative cancer” (TNBC). Here, we report that CD146 is a unique activator of EMTs significantly correlates with TNBC. In epithelial cells, overexpression down-regulated markers up-regulated mesenchymal markers, promoted cell migration invasion, induced stem cell-like properties. We further found RhoA pathways positively regulated...
A novel frequency selective surface (FSS) based on substrate integrated waveguide (SIW) technology is investigated with simulation and experiment. The periodic unit made of a SIW cavity slots the top bottom surfaces, whole FSS fabricated microwave standard PCB process. high-Q property cavities greatly improved selectivity FSS, which significant for application in antenna cover or object stealth etc. finite difference domain (FDFD) method adopted to simulate transmission reflection...
We present extensive optical (UBVRI), near-infrared (JK) light curves and spectroscopy of the Type Ia supernova SN 2006X in nearby galaxy NGC 4321 (M100). Our observations suggest that either has an intrinsically peculiar color evolution or it is highly reddened [E(B − V)host = 1.42 ± 0.04 mag ] with RV 1.48 0.06, much lower than canonical value 3.1 for average Galactic dust. also one highest expansion velocities ever published Ia. Compared other SNe we analyzed, a broader curve U band, more...
Angiogenesis is a fundamental process that involves in tumor progression and metastasis. Vascular endothelial growth factor (VEGF) family their receptors are identified as the most prominent regulators of angiogenesis. However, clinical efficacy anti-VEGF/VEGFR therapy not ideal, prompting needs to further understand mechanisms behind Here, we found Dickkopf associated protein 2 (DKK2), secretory highly expressed metastatic colorectal cancer tissues, could stimulate angiogenesis via classic...
Sporadic and non-hereditary mutations account for the majority of colorectal cancers (CRC). After loss adenomatous polyposis coli (APC) function activation β-catenin/LEF signaling pathway, activating in Kras are major drivers sporadic CRC. Preventing outgrowth cells that develop will decrease Resveratrol, a naturally occurring polyphenolic compound has anti-inflammatory, anti-oxidant anti-cancer activities. We used genetically engineered mouse model CRC where APC locus is knocked out...
Abstract Background Alzheimer’s disease (AD) is a degenerative neurological disorder. Recent studies have indicated that histone deacetylases (HDACs) are among the most prominent epigenetic therapy targets and HDAC inhibitors therapeutic effects on AD. Here, we identified sodium valproate (VPA), pan-HDAC inhibitor, WT161, novel HDAC6 selective as potential agents for Underlying molecular mechanisms were investigated. Methods A cellular model, N2a-APPswe, was established via lentiviral...
To develop and validate a computed tomography (CT)-based deep learning radiomics model to predict treatment response progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) treated transarterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC) combined PD-1 inhibitors tyrosine kinase (TKIs). This retrospective study included 172 uHCC who underwent combination therapy of TACE-HAIC TKIs inhibitors. Among them, 122 were from the...
The study aimed to investigate changes in corticomuscular coupling during elbow flexion and extension stroke survivors using functional near-infrared spectroscopy (fNIRS) surface electromyography (sEMG), evaluate the relationship between characteristics clinical assessment scales. This recruited 12 age-matched healthy subjects, further divided subjects into affected side group, healthy-side group group. They performed tasks at 30% 70% of maximum voluntary contraction (MVC). cerebral blood...
Despite the fact that morbidity and mortality rates significantly increase with tricuspid regurgitation (TR) severity, limited treatment options are available for treating severe TR. The single-arm, multicentre, prospective Confirmatory Clinical Study of Treating Tricuspid Regurgitation With K-Clip TM Transcatheter Annuloplasty System (TriStar) evaluated 1-year outcomes novel transcatheter annuloplasty system in secondary Between May 2022 October 2022, patients ≥severe TR despite optimal...
ABSTRACT Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators cell cycle progression. Here we show that nanomolar concentrations lactacystin, a specific irreversible inhibitor 20S proteasome, inhibit development exoerythrocytic erythrocytic stages malaria parasite. Although lactacystin-treated Plasmodium berghei sporozoites are still invasive, their into forms (EEF) is inhibited in vitro vivo. Erythrocytic schizogony P. falciparum...
Few mutations have been found in the human leptin gene and relationship between sequence variation overweight is uncertain. To determine whether within its regulatory elements contribute to extreme obesity, we screened ∼3 kb of 5′ flanking region three exons 125 unrelated extremely obese (BMI ≥ 40 kg/m 2 ) 86 average weight women < 27 ). Within protein coding regions only one heterozygous silent mutation was (codon 102; AAC/AAT). region, six frequent variants were detected ( q > 0.10),...
FTO is a gene located in chromosome region 16q12.2. Recently two studies have found associations of several single nucleotide polymorphisms (SNPs) with body mass index (BMI) and obesity, particularly rs1421085, rs17817449, rs9939609. We examined these three SNPs 583 extremely obese women current BMI greater than 35 kg/m2 lifetime 40 kg/m2, 544 controls who were currently normal weight (BMI<25 kg/m2) had never been overweight during their lifetimes. detected highly significant obesity alleles...
Over recent decades sulfur fumigation has been becoming abused in processing some freshly harvested Chinese medicinal herbs, although it is questioned whether can result changes efficacy and safety of the herbs. One herbs commonly processed by Codonopsis Radix (Dangshen). A report showed that lobetyolin content sulfur-fumigated Dangshen was lower than air-dried Dangshen. Whereas there no investigation designed to compare chemical profiles In present study, a rapid versatile...