A5072175699- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Insect-Plant Interactions and Control
- Genetic and phenotypic traits in livestock
- Culinary Culture and Tourism
- Nutrition, Genetics, and Disease
- Phytoplasmas and Hemiptera pathogens
- Asthma and respiratory diseases
- Orthoptera Research and Taxonomy
- Sensory Analysis and Statistical Methods
- Diet and metabolism studies
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Insect Resistance and Genetics
- RNA Research and Splicing
- Obesity, Physical Activity, Diet
- Sinusitis and nasal conditions
- Genetic Associations and Epidemiology
- Meat and Animal Product Quality
- Insect symbiosis and bacterial influences
- Epigenetics and DNA Methylation
Monell Chemical Senses Center
2016-2025
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Shandong Provincial Institute of Dermatology and Venereology
2024
Academy of Medical Sciences
2024
Zhejiang University
2015-2023
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2022
Nankai University
2019-2021
Nanjing Agricultural University
2015-2017
New Mexico Department of Health
2016
Objective. Flavor is the primary dimension by which young children determine food acceptance. However, are not merely miniature adults because sensory systems mature postnatally and their responses to certain tastes differ markedly from adults. Among these differences heightened preferences for sweet-tasting greater rejection of bitter-tasting foods. The present study tests hypothesis that genetic variations in newly discovered TAS2R38 taste gene as well cultural associated with sensitivity...
Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that bitter taste receptor T2R38 regulates mucosal innate of human upper airway. Utilizing immunofluorescent live cell imaging techniques in polarized primary sinonasal cells, demonstrate is expressed epithelium activated response to acyl-homoserine lactone quorum-sensing molecules secreted Pseudomonas aeruginosa other gram-negative bacteria. Receptor activation...
Background: Phenylthiocarbamide (PTC) and 6‐ n ‐propylthiouracil (PROP), chemically related compounds, are probes for genetic variation in bitter taste, although PROP is safer with less sulfurous odor. Threshold distinguishes nontasters (increased threshold) from tasters (lower threshold); perceived intensity subdivides into medium (PROP bitter) supertasters very bitter). Compared supertasters, have fewer taste papillae on the anterior tongue (fungiform papillae) experience negative (e.g.,...
Mammalian sweet taste is primarily mediated by the type 1 receptor Tas1r2/Tas1r3, whereas Tas1r1/Tas1r3 act as principal umami receptor. Bitter a different group of G protein-coupled receptors, Tas2rs, numbering 3 to ∼66, depending on species. We showed previously that behavioral indifference cats toward sweet-tasting compounds can be explained pseudogenization Tas1r2 gene, which encodes To examine generality this finding, we sequenced entire coding region from 12 species in order Carnivora....
The present study aimed to determine if salty and sweet taste preferences in children are related each other, markers of growth, genetic differences.
Abstract In a preregistered, cross-sectional study, we investigated whether olfactory loss is reliable predictor of COVID-19 using crowdsourced questionnaire in 23 languages to assess symptoms individuals self-reporting recent respiratory illness. We quantified changes chemosensory abilities during the course illness 0–100 visual analog scales (VAS) for participants reporting positive (C19+; n = 4148) or negative (C19−; 546) laboratory test outcome. Logistic regression models identified...
Although domestic cats (Felis silvestris catus) possess an otherwise functional sense of taste, they, unlike most mammals, do not prefer and may be unable to detect the sweetness sugars. One possible explanation for this behavior is that lack sensory system taste sugars therefore are indifferent them. Drawing on work in mice, demonstrating alleles sweet-receptor genes predict low sugar intake, we examined possibility involved initial transduction sweet perception might account indifference...
Obesity is a highly prevalent, multigenic trait that predicts increased morbidity and mortality. Here we report results from genome scan based on 354 markers in 513 members of 92 nuclear families ascertained through extreme obesity normal body weight. The average marker interval was approximately 10 cM. We examined four correlated phenotypes, including the body-mass index (BMI) (both as quantitative discrete with threshold BMI > or /=30 kg/m2) percentage fat 40%) assessed by bioelectrical...
Abstract Background The purpose of this study was to investigate the effect TAS2R38 haplotypes and age on human bitter taste perception. Results Children (3 10 yrs), adolescents (11 19 yrs) adults (mostly mothers, 20 55 yrs (N = 980) were measured for thresholds 6-n-propylthiouracil (PROP) genotyped three polymorphisms AS2R38 gene (A49P, V262A, I296V). Subjects grouped by haplotype age, as well sex race/ethnicity, compared PROP thresholds. with same similar in threshold regardless...
The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to Tas1r3 (taste receptor) gene. goal this study was identify sequence variants associated with saccharin preference in a large number inbred strains. Initially, we sequenced ∼6.7 kb gene and its flanking regions from six strains high low preference, including which alleles were described originally (C57BL/6J, b ; DBA/2J, d ). Of 89 detected among these strains, eight polymorphic sites...
Background The bitter taste receptor T2R38 was recently described to play a role in upper airway innate mucosal defense. When activated by bacterial quorum‐sensing molecules, stimulates the ciliated epithelial cells produce nitric oxide (NO), resulting bactericidal activity and an increase mucociliary clearance (MCC). Polymorphisms within gene ( TAS2R38 ) confer variability activation of yielding dramatic differences defensive responses (NO production accelerated MCC) microbial stimulation...
The genomes and transcriptomes of hundreds insects have been sequenced. However, insect community lacks an integrated, up-to-date collection gene data. Here, we introduce the first release InsectBase, available online at http://www.insect-genome.com. database encompasses 138 genomes, 116 transcriptomes, 61 sets, 36 families 60 insects, 7544 miRNAs 69 96 925 piRNAs Drosophila melanogaster Chilo suppressalis, 2439 lncRNA Nilaparvata lugens, 22 536 pathways 78 678 881 untranslated regions (UTR)...
The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and propylthiouracil (PROP) solutions were examined in 1457 twins their siblings. Previous heritability modeling these bitter stimuli indicated a common genetic factor for quinine, caffeine SOA (22–28%), as well separate specific factors PROP (72%) (15%). To identify the genes involved, we performed genome-wide association study with same sample analysis, genotyped approximately 610 000 single-nucleotide...