A5015194475- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Neurobiology and Insect Physiology Research
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Receptor Mechanisms and Signaling
- Central Venous Catheters and Hemodialysis
- Ion Channels and Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Regulation of Appetite and Obesity
- 3D Printing in Biomedical Research
- Bacteriophages and microbial interactions
- Retinal Development and Disorders
- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- Acupuncture Treatment Research Studies
- Chemokine receptors and signaling
- Corneal Surgery and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Nosocomial Infections in ICU
- Liver Disease Diagnosis and Treatment
Zhejiang University
2016-2025
Shandong Tumor Hospital
2022-2025
Shandong First Medical University
2022-2025
Monell Chemical Senses Center
2014-2024
Institute for Advanced Study
2023-2024
Zhejiang Chinese Medical University
2008-2024
Shanghai Advanced Research Institute
2022-2023
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022-2023
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2022-2023
Zhejiang Provincial Hospital of TCM
2013-2022
Significance Intestinal tuft cells are sentinels monitoring the luminal contents and play a critical role in type 2 immunity. In this work, Trichinella spiralis excretion–secretion extract were shown to directly induce interleukin 25 (IL-25) release from intestinal villi, evoke calcium responses cells, activate Tas2r bitter-taste receptors, whereas bitter compound salicin was IL-25. Gα-gustducin/Gβ1γ13 and/or Gαo/Gβ1γ13, Plcβ2, Ip 3 r2, Trpm5 comprise signal transduction pathways that...
Although domestic cats (Felis silvestris catus) possess an otherwise functional sense of taste, they, unlike most mammals, do not prefer and may be unable to detect the sweetness sugars. One possible explanation for this behavior is that lack sensory system taste sugars therefore are indifferent them. Drawing on work in mice, demonstrating alleles sweet-receptor genes predict low sugar intake, we examined possibility involved initial transduction sweet perception might account indifference...
The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to Tas1r3 (taste receptor) gene. goal this study was identify sequence variants associated with saccharin preference in a large number inbred strains. Initially, we sequenced ∼6.7 kb gene and its flanking regions from six strains high low preference, including which alleles were described originally (C57BL/6J, b ; DBA/2J, d ). Of 89 detected among these strains, eight polymorphic sites...
Taste disorders, including taste distortion and loss, negatively impact general health quality of life. To understand the underlying molecular cellular mechanisms, we set out to identify inflammation‐related molecules in tissue assess their role development dysfunctions. We found that 10 12 mammalian Toll‐like receptors (TLRs), type I II interferon (IFN) receptors, downstream signaling components are present tissue. Some TLRs appear be selectively or more abundantly expressed buds than...
Abstract Background The mammalian taste bud, a complex collection of sensory cells, supporting and immature basal is the structural unit for detecting stimuli in oral cavity. Even though cells bud undergo constant turnover, homeostasis maintained by balancing cell proliferation death. Compared with nongustatory lingual epithelial express higher levels several inflammatory receptors signalling proteins. Whether inflammation, an underlying condition some diseases associated disorders,...
Mammalian spermatogenesis and sperm maturation are susceptible to the effects of internal external factors. However, how male germ cells interact with respond these elements including those potentially toxic substances is poorly understood. Here, we show that many bitter-taste receptors (T2rs), which believed function as gatekeepers in oral cavity detect innately prevent ingestion poisonous bitter-tasting compounds, expressed mouse seminiferous tubules. Our situ hybridization results...
Abstract Background Older adult patients mainly suffer from multiple comorbidities and are at a higher risk of deep venous thrombosis (DVT) during their stay in the intensive care unit (ICU) than younger patients. This study aimed to analyze factors for DVT critically ill older Methods was subgroup analysis prospective, multicenter, observational who were admitted ICU 54 hospitals Zhejiang Province September 2019 January 2020 (ChiCTR1900024956). Patients aged > 60 years old on admission...
We investigated the expression of Ggamma13, a recently discovered G protein subunit, and selection Gbeta subunits in retinal bipolar cells, by using transgenic mouse strain which green fluorescent is strongly expressed single type cone cell. The cells have ON morphology, patch-clamp recordings slices confirmed that they are physiological type. Immunohistochemistry showed Ggamma13 rod where it colocalized dendrites with Galphaomicron. OFF were identified among dissociated their fluorescence...
Patients with viral and bacterial infections or other inflammatory illnesses often experience taste dysfunctions. The agents responsible for these disorders are thought to be related infection-induced inflammation, but the mechanisms not known. As a first step in characterizing possible role of inflammation disorders, we report here evidence presence interferon (IFN)-mediated signaling pathways bud cells. IFN receptors, particularly IFN-γ receptor IFNGR1, coexpressed cell-type markers...
The activation of G-protein-coupled olfactory receptors on the sensory neurons (OSNs) triggers a signaling cascade, which is mediated by heterotrimeric G-protein consisting α, β, and γ subunits. Although its α subunit, Gαolf, has been identified well characterized, identities β subunits their function in signal transduction, however, have not established yet. We, others, found expression Gγ13 epithelium, particularly cilia OSNs. In this study, we generated conditional gene knock-out mouse...
Taste buds are chemosensory structures widely distributed on the surface of oral cavity and larynx. cells, exposed to environment, face great challenges in defense against potential pathogens. While immune such as T-cells macrophages, rarely found taste buds, high levels expression some immune-response-associated molecules observed buds. Yet, cellular origins these cytokines remain be determined. Here, we show that a specific subset cells selectively expresses inflammatory cytokine tumor...
Although inflammatory responses are a critical component in defense against pathogens, too much inflammation is harmful. Mechanisms have evolved to regulate inflammation, including modulation by the anti-inflammatory cytokine interleukin-10 (IL-10). Previously we shown that taste buds express various molecules involved innate immune responses, proinflammatory tumor necrosis factor (TNF). Here, using reporter mouse strain, show cells also IL-10. Remarkably, IL-10 produced only specific subset...