The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/main.php) has been updated and expanded. It now hosts 1228 entries with 65 anticancer, 76 antiviral (53 anti-HIV), 327 antifungal 944 antibacterial peptides. second version of our (APD2) allows users to search families (e.g. bacteriocins, cyclotides, or defensins), sources fish, frogs chicken), post-translationally modified peptides amidation, oxidation, lipidation, glycosylation d-amino acids), binding targets membranes,...

Although domestic cats (Felis silvestris catus) possess an otherwise functional sense of taste, they, unlike most mammals, do not prefer and may be unable to detect the sweetness sugars. One possible explanation for this behavior is that lack sensory system taste sugars therefore are indifferent them. Drawing on work in mice, demonstrating alleles sweet-receptor genes predict low sugar intake, we examined possibility involved initial transduction sweet perception might account indifference...

Background —We have developed a transgenic mouse with cardiac-restricted overexpression of tumor necrosis factor-α (TNF-α). These mice develop heart failure phenotype characterized by left ventricular dysfunction and remodeling, pulmonary edema, elevated levels TNF-α in the peripheral circulation from cardiac spillover. Given that causes atrophy loss function respiratory muscle, we asked whether diaphragm contractile losses were caused oxidative stress or tissue remodeling. Methods Results...

Ren, B., Zhang, J., Li, X., Fan, Dong, S., Liu, P. and Zhao, B. 2014. Effects of waterlogging on the yield growth summer maize under field conditions. Can. J. Plant Sci. 94: 23–31. A experiment was performed to study effects for different durations (3 6 d) at three-leaf stage (V3), six-leaf (V6), 10th day after tasseling (10VT). The results 2 yr indicated that development grain responses depended both stress severity (intensity duration) stage. Yield decreased significantly with an increased...

The fungal endophyte Gilmaniella sp. AL12 can establish a beneficial association with the medicinal herb Atractylodes lancea, and improve plant growth sesquiterpenoids accumulation, which is termed "double promotion". Our previous studies have uncovered underling primary mechanism based on some physiological evidences. However, global understanding of gene or protein expression regulation in secondary metabolism related regulatory processes still lacking. In this study, we employed...

Linear codes with certain special properties have received renewed attention in recent years due to their practical applications. Among them, binary linear complementary dual (LCD) play an important role implementations against side-channel attacks and fault injection attacks. Self-orthogonal can be used construct quantum codes. In this paper, four classes of are constructed via a generic construction which has been intensively investigated the past decade. Simple characterizations these LCD...

Ren, B., Zhang, J., Li, X., Fan, Dong, S., Liu, P. and Zhao, B. 2014. Effects of waterlogging on the yield growth summer maize under field conditions. Can. J. Plant Sci. 94: 23-31. A experiment was performed to study effects for different durations (3 6 d) at three-leaf stage (V3), six-leaf (V6), 10th day after tasseling (10VT). The results 2 yr indicated that development grain responses depended both stress severity (intensity duration) stage. Yield decreased significantly with an increased...

An increasing number of studies have demonstrated that circular RNAs (circRNAs), as promising therapeutic targets, are essential for diverse human diseases, especially cancer. However, the potential functions and complex mechanisms most circRNAs in osteosarcoma (OS) still not fully elucidated. In present study, we obtained expression profile from a GEO database (GSE96964) identified hsa_circ_0000073 highly expressed candidate OS. Overexpression accelerated proliferation, migration, invasion...

Macrophages, an important type of immune cells, are generally polarized to classically activated macrophage (M1) or alternatively (M2) respond environmental stimuli. Signal transducer and activator transcription 1 (STAT1), a very factor, can promote M1 polarization. However, the mechanisms regulating STAT1 in polarization remain unclear. In present study, was markedly elevated, however, miR-19a-3p down-regulated interferon (IFN)-γ lipopolysaccharide (LPS) treated RAW264.7 dual-luciferase...

Background: Complex coronary lesions have been an understudied aspect of artery disease in elderly patients. Oxidative stress and inflammation may be implicated the pathogenesis complex lesions. Objective: The aim this study is to investigate interplay between pro-oxidative response, pro-inflammatory Methods: Enzyme-linked immunosorbent assays for detection serum biomarkers [reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ),...

The objective of this study was to evaluate the safety and efficacy dual antiplatelet pretreatment combined with low-dose rtPA therapy in patients acute mild ischemic stroke, guided by multimodal MRI. In study, 383 stroke (NIHSS ≤ 5) who had symptom onset within 4.5 hours MRI screening were selected. Patients plus group (164 cases) received (0.6 mg/kg) intravenous thrombolysis. standard-dose (112 conventional-dose (0.9 Additionally, did not receive thrombolysis (107 underwent 21 days oral...

Background: The predictive effect of systemic inflammatory factors on postoperative pulmonary complications in elderly patients remains unclear. In addition, machine learning models are rarely used prediction for patients. Patients and Methods: We retrospectively evaluated who underwent general anesthesia during a 6-year period. Eligible were randomly assigned 7:3 ratio to the development group validation group. Least logistic absolute shrinkage selection operator (LASSO) regression model...

Undaria pinnatifida is an important economic brown alga in East Asian countries. However, its genetic and genomic information very scarce, which hinders further research this species. A high-density map a basic tool for fundamental applied such as discovery of functional genes mapping quantitative trait loci (QTL). In study the recently developed specific length amplified fragment sequencing (SLAF-seq) technology was employed to construct linkage locate sex determining locus U. pinnatifida....

Infertility is one of the most common reproductive system diseases, and no effective method available for its treatment. Although in vitro fertilization (IVF) has been widely used to enhance clinical pregnancy outcome infertility, unsatisfied rate with unknown reasons obtained. To identify possible cause IVF failure, 555 patients were enrolled present study determine their relevant characteristics vaginal microbiota. Our results indicated that age endometrium thickness significantly affected...

Feature point matching is a fundamental and challenging problem in many computer vision applications. In this paper, robust feature algorithm named spatial order constraints bilateral-neighbor vote (SOCBV) proposed to remove outliers for set of matches (including outliers) between two images. A directed k nearest neighbor (knn) graph match sets generated, the formulated as binary discrimination problem. process, class labeled matrix built via defined on edges that connect its knn. Then,...

Myocardial fibrosis after acute myocardial infarction (AMI) is one of the main causes remodeling and heart function abnormalities. Bone morphogenetic protein-7 (BMP-7) has been reported to play essential roles in anti-fibrosis. In this study, we demonstrated role exogenous BMP-7 on recovery AMI. A rat model AMI was established via ligation left anterior descending coronary artery (LAD). Twenty rats were grouped into sham group which underwent chest open operation, but did not receive LAD...

As a chronic degenerative joint disease, the characteristics of osteoarthritis (OA) are degeneration articular cartilage, subchondral bone sclerosis and hyperplasia. It has been reported that microRNA (miR)‑186‑5p serves key role in development various tumors, such as osteosarcoma, non‑small‑cell lung cancer cells, glioma colorectal cancer. The present study aimed to investigate effect miR‑186‑5p OA. Different concentrations IL‑1β were used treat human chondrocyte cell line CHON‑001 simulate...

Abstract Infertile people who suffered from loss of uterine structures and/or functions can be treated through gestational surrogacy or uterus transplantation, which remains challenging due to the ethical and social issues, lack donor organs as well technical safety risks. One promising solution is regenerate reconstruct a bioartificial for transplantation engineering architecture appropriate cellular constituents. Here, we developed well-defined system functional rat recellularization...

An efficient in vitro regeneration system via somatic embryogenesis was developed for a fern species Adiantum capillus-veneris. Adventitious shoots, green globular bodies (GGBs) and calli were obtained with the maximal induction rate on Murashige Skoog (MS) medium of low concentrations 6-benzyladenine (BA) (0–1.0 mg/L), 2.0 mg/L BA without 2,4-dichlorophenoxyacetic acid (2,4-D), 0.5 2,4-D 0.5–1.0 6-BA, respectively. Cyto-morphological histological changes shoot development GGBs examined. For...