A5100747047- Glycosylation and Glycoproteins Research
- Forensic and Genetic Research
- Genetic Mapping and Diversity in Plants and Animals
- Galectins and Cancer Biology
- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Cell death mechanisms and regulation
- Genetics and Plant Breeding
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Climate variability and models
- Cryospheric studies and observations
- Climate change and permafrost
- Forensic Anthropology and Bioarchaeology Studies
- Caveolin-1 and cellular processes
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
- Carbohydrate Chemistry and Synthesis
- Arctic and Antarctic ice dynamics
- Hydrology and Watershed Management Studies
- Plant Disease Resistance and Genetics
- RNA Interference and Gene Delivery
- Wheat and Barley Genetics and Pathology
- Endoplasmic Reticulum Stress and Disease
Dalian University
2015-2025
Dalian University of Technology
2016-2025
Guiyang Medical University
2017-2025
Xi'an University of Architecture and Technology
2021-2024
Institute of Geographic Sciences and Natural Resources Research
2021-2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2021-2024
Centro Internacional de Mejoramiento de Maíz Y Trigo
2017-2024
Lanzhou Institute of Chemical Physics
2024
Yantai University
2024
Genomic selection is being used increasingly in plant breeding to accelerate genetic gain per unit time. One of the most important applications genomic maize predict and select best un-phenotyped lines bi-parental populations based on estimated values. In present study, 22 tropical genotyped with low density SNPs were evaluate prediction accuracy (
Drought stress is recognized as a major constraint to maize yield production, the heat alone and in combination with drought are likely become increasing constraints. The association mapping genomic prediction analyses were conducted collection of 300 tropical subtropical inbred lines reveal genetic architecture grain flowering time under well-watered, stress, combined conditions. Out 381,165 genotyping-by-sequencing SNPs, 1661 significantly associated all 12 trait-environment combinations,...
The wet chemical processes of LiFePO4, hydrothermal synthesis and hydrometallurgical recovery, are great importance during the life cycle LiFePO4. To analyze these two processes, E-pH diagrams for Li-Fe-P-H2O system plotted from 298 to 473 K in this study. can well explain practical operating conditions recovery provide thermodynamic basis them. Besides, suitable LiFePO4 obtained diagrams, including high temperature, low redox potential, optimum pH 7.8–8.4, excess stoichiometric lithium. As...
Abstract Genotyping-by-Sequencing (GBS) is a low-cost, high-throughput genotyping method that relies on restriction enzymes to reduce genome complexity. GBS being widely used for various genetic and breeding applications. In the present study, 2240 individuals from eight maize populations, including two association populations (AM), backcross first generation (BC1), BC1F2, F2, double haploid (DH), intermated B73 × Mo17 (IBM), recombinant inbred line (RIL) population, were genotyped using...
Abstract O-GlcNAc modification plays critical roles in regulating the stress response program and cellular homeostasis. However, systematic multi-omics studies on regulated mechanism have been limited. Here, comprehensive data are obtained by a chemical reporter-based method to survey function human breast cancer cells stimulated with genotoxic agent adriamycin. We identify 875 stress-induced chromatin-associated proteins (OCPs), including 88 transcription factors cofactors (OCTFs),...
FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic functions remain elusive. Here, we demonstrate that O-linked β- N -acetylglucosamine modification (O-GlcNAcylation) of promotes metastasis orchestrating numerous regulators. O-GlcNAcylation at Thr 432 , Ser 441 and 443 regulates stability assembly with chromatin. shapes interactome, especially triggering recruitment...
Chemoresistance has become a major obstacle to the success of cancer therapy, but mechanisms underlying chemoresistance are not yet fully understood. O-GlcNAcylation is post-translational modification that regulated by hexosamine biosynthetic pathway (HBP) and an important role in wide range cellular functions. Here we assessed investigated mechanisms. The results showed HBP cell regulating O-GlcNAcylation. An increase levels indicates increased resistance cells chemotherapy. Acute treatment...
Background and Purpose Although the ongoing clinical trials of ABT‐263 ABT‐199 in chronic lymphocytic leukaemia (CLL) have indicated that BH3 mimetics hold considerable promise, understanding mechanism CLL resistance to remains a challenge. Experimental Approach The LD 50 values ABT‐737, number primary cells from 40 patients, were determined. levels Bcl‐2 family proteins, including phosphorylated (pBcl‐2) their interactions measured by immunoblotting co‐immunoprecipitation. In vitro binding...
O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processes through reversible post-translational modification of nuclear and cytoplasmic proteins. However, the function O-GlcNAcylation is still not well understood. Cell permeable OGT inhibitors are needed to manipulate levels clarify regulatory mechanism this modification. Here, we report a specific natural-product inhibitor (L01), which was identified from structure-based virtual screening analysis. L01...
Fusarium ear rot (FER) is a destructive maize fungal disease worldwide. In this study, three tropical populations consisting of 874 inbred lines were used to perform genome-wide association study (GWAS) and genomic prediction (GP) analyses FER resistance. Broad phenotypic variation high heritability for observed, although it was highly influenced by large genotype-by-environment interactions. the lines, GWAS with general linear model (GLM) identified 3034 single-nucleotide polymorphisms...
An increasing number of studies have demonstrated that circular RNAs (circRNAs), as promising therapeutic targets, are essential for diverse human diseases, especially cancer. However, the potential functions and complex mechanisms most circRNAs in osteosarcoma (OS) still not fully elucidated. In present study, we obtained expression profile from a GEO database (GSE96964) identified hsa_circ_0000073 highly expressed candidate OS. Overexpression accelerated proliferation, migration, invasion...
ABSTRACT Obesity and underweight pose significant threats to human health as non‐communicable diseases. In addition, body shape (like obesity or emaciation) is an important investigative clue in forensic practice. Body mass index (BMI) a common indicator reflect of individual. However, there lack rapid, simple, effective methods for identifying different BMI individuals. This research aimed delve into the correlations between salivary proteins BMI. A total 418 differential expression (DEPs)...
This study aimed to explore the role of lactoferrin (LTF) in atherosclerosis (AS) and its possible mechanisms. Human left coronary artery tissues were collected divided into control (CON), heart disease (CHD) sudden death (SCD) groups. Pathologic changes (including plaque area, necrotic core, collagen fibers, foam cell content) observed. The LTF, P62, 4-hydroxynonenal (4-HNE) expression levels assessed. ApoE–/– AS mouse model was established. pathological related protein analyzed after...
Genomic selection with a multiple-year training population dataset could accelerate early-stage testcross testing by skipping the first-stage yield testing, which significantly saves time and cost of testing. With development doubled haploid (DH) technology, main task for maize breeder is to estimate breeding values thousands DH lines annually. In genomic (GS) offers opportunity replacing expensive multiple-environment phenotyping phenotypic lower-cost genotyping estimated value (GEBV)-based...
Abstract O‐GlcNAcylation is a posttranslational modification that regulates numerous nuclear and cytoplasmic proteins emerging as key regulator of various biological processes, such transcription, signal transduction, cell motility. Although increasing evidence has shown elevated levels global are linked to the metastasis in hepatocellular carcinoma (HCC) cells, underlying mechanism still ambiguous. In this study, we demonstrated forkhead box protein A2 (FOXA2), an essential transcription...
Common rust is one of the major foliar diseases in maize, leading to significant grain yield losses and poor quality. To dissect genetic architecture common resistance, a genome-wide association study (GWAS) panel bi-parental doubled haploid (DH) population, DH1, were used perform GWAS linkage mapping analyses. The results revealed six single-nucleotide polymorphisms (SNPs) significantly associated with quantitative resistance at very stringent threshold P- value 3.70 × 10 –6 bins 1.05,...