A5085266293- Nuclear reactor physics and engineering
- Nuclear Materials and Properties
- Nerve injury and regeneration
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Graphite, nuclear technology, radiation studies
- Neurogenesis and neuroplasticity mechanisms
- Crystallography and Radiation Phenomena
- Lung Cancer Treatments and Mutations
- Spine and Intervertebral Disc Pathology
- Advanced X-ray Imaging Techniques
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Electrospun Nanofibers in Biomedical Applications
- Inflammatory Bowel Disease
- Lung Cancer Diagnosis and Treatment
- Software Engineering Research
- Advanced Malware Detection Techniques
- Lung Cancer Research Studies
- Nuclear Physics and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Molecular Junctions and Nanostructures
- Spinal Cord Injury Research
Peking University Shenzhen Hospital
2025
Air Force Medical University
2008-2025
Xijing Hospital
2017-2025
Guiyang Medical University
2019-2025
Zhejiang University
2022-2024
Tsinghua University
2010-2024
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2017-2024
Zhongyuan University of Technology
2010-2024
Hangzhou Cancer Hospital
2020-2024
First Affiliated Hospital of Bengbu Medical College
2024
Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy, biased mRNA translation, and interferon-mediated immune responses. However, detailed mechanisms physiological relevance STING-induced senescence are not fully understood. Here, we unexpectedly found that interferon regulatory factor 3 (IRF3), activated during innate sensing, forms substantial endogenous complexes in the nucleus...
DNA methylation modifications are an important mechanism affecting the process of atherosclerosis (AS). Previous studies have shown that Galectin-8 (GAL8) level is associated with sudden death coronary heart disease or acute events disease. However, GAL8 and gene expression in AS has not been elucidated, prompting us to carry out further research on it. ApoE-/- mice were used establish model, inhibitor DO05 MAPK/mTOR UO126 for intervention. Pyrosequencing was detect changes levels mouse...
Abstract Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in regenerative medicine because of their cargos abundant bioactive cues. Several strategies are proposed to tune EVs production vitro. However, it remains a challenge for manipulation vivo, which poses significant difficulties EVs‐based that aim promote tissue regeneration, particularly long‐term treatment diseases like peripheral neuropathy. Herein, superparamagnetic nanocomposite scaffold capable...
This study aimed to explore the role of lactoferrin (LTF) in atherosclerosis (AS) and its possible mechanisms. Human left coronary artery tissues were collected divided into control (CON), heart disease (CHD) sudden death (SCD) groups. Pathologic changes (including plaque area, necrotic core, collagen fibers, foam cell content) observed. The LTF, P62, 4-hydroxynonenal (4-HNE) expression levels assessed. ApoE–/– AS mouse model was established. pathological related protein analyzed after...
The nerve conduit with biofunctionalities can regulate neurite outgrowth, as well the migration, proliferation, and myelination activity of Schwann cells. In present study, polycaprolactone (PCL) conduits are coated Naphthalene-phenylalanine-phenylalanine-glycine-arginine-glycine-aspartic (Nap-FFGRGD) Naphthalene-phenylalanine-phenylalanine-glycine-cysteine-aspartic-proline-glycine-tyrosine-isoleucine-glycine-serine-arginine (Nap-FFGCDPGYIGSR) by self-assembly. vitro studies demonstrate that...
Peripheral nerves are unique in their remarkable elasticity. Schwann cells (SCs), important components of the peripheral nervous system (PNS), constantly subjected to physiological and mechanical stresses from dynamic stretching compression forces during movement. So far, it is not clear if SCs sense respond signals. It also unknown whether stimuli can interfere with intercellular communications between neurons SCs, what role extracellular vesicles (EVs) play this process. The present study...
Abstract The high-temperature reactor pebble-bed module (HTR-PM) is a modular gas-cooled demonstration power plant. Its first criticality experiment scheduled for the latter half of 2021. Before performing experiment, prediction calculation was performed using PANGU code. This paper presents details predicting HTR-PM PANGU, including input model and parameters, numerical results, uncertainty analysis. accuracy code demonstrated by comparing it with high-fidelity Monte Carlo solution, same...
Addressing the challenge of promoting directional axonal regeneration in a hostile astrocytic scar, which often impedes recovery following spinal cord injury (SCI), remains daunting task. Cell transplantation is promising strategy to facilitate nerve restoration SCI. In this research, pro-regeneration system developed, namely miR-26a@SPIONs-OECs, for olfactory ensheathing cells (OECs), preferred choice SCI patients. These entities show high responsiveness external magnetic fields (MF),...
It has been shown that exposure to hexavalent Chromium, Cr (Ⅵ), via nasal cavity can have neurotoxicological effects and induces behavioral impairment due the fact blood brain barrier (BBB) does not cover olfactory bulb. But whether (Ⅵ) cross BBB a toxicological in central nervous system (CNS) remains unclear. Therefore, we investigated of on mice treated with different concentrations time (14 days 28 days) intraperitoneal injection. Results revealed accumulated hypothalamus (HY) timely...
Photoinduced processes, leading to charge-transfer states with extended lifetimes, are of key importance for solar-energy-conversion applications. Utilizing external heavy-atom effect allowed us photogenerate long-lived transients electron donor−acceptor dyads. For an acceptor and a principal chromophore the dyads, we selected N-methylacridinium, donors thiophene, bithiophene, terthiophene were selected. While photoinduced charge transfer, mediated by investigated occurred in picosecond time...
Controlling charge transfer at a molecular scale is critical for efficient light harvesting, energy conversion, and nanoelectronics. Dipole-polarization electrets, the electrostatic analogue of magnets, provide means “steering” electron transduction via local electric fields generated by their permanent dipoles. Here, we describe first demonstration utility anthranilamides, moieties with ordered dipoles, controlling intramolecular transfer. Donor–acceptor dyads, each containing single...
Biochemical and physical guidance cues are both pivotal for axonal nerve regeneration. However, fabrication of a platform that can integrate biochemical gradients topographical remains challenging, especially in three-dimensional (3D) scaffold closely mimics vivo outgrowth conditions ready to be used repair. In this study, new method was introduced construct 3D scaffolds displaying continuous along longitudinally oriented microchannels by combining the modified printing directional freezing...
Owing to its crucial role in the human body, collagen has immense potential as a material for biofabrication of tissues and organs. However, highly refined fabrication using remains difficult, primarily because notably soft properties. A quantitative platform construct collagen-based peripheral nerve grafts, incorporating bionic structural chemical guidance cues, is introduced. viscoelastic model collagen, which facilitates simulating relaxation fabricating neural achieving maximum channel...
We introduced a MXene-based field-effect transistor (FET) biosensor with nano-flower morphology for ultrasensitive determination of miR-21, crucial biomarker in lung cancer diagnosis.
Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. This report discusses biomimetic dextral hydrogel (DH) with right-handed nanofibers that specifically reprograms lipid metabolism NSCs, promoting their differentiation and rapid damaged axons. The underlying mechanism is intrinsic stereoselectivity between DH fatty acid-binding protein 5...
A facile nonlithographic method for expedient fabrication of microfluidic devices poly(dimethylsiloxane) is described. Positive-relief masters the molds are directly printed on smooth substrates. For formation connecting channels and chambers inside polymer components devices, cavity-forming elements adhered to surfaces masters. Using this approach, we fabricated detection bacterial spores basis enhancement emission terbium (III) ions.
The photophysical properties of a series 9-arylacridinium conjugates in solid glass matrices composed sucrose octaacetate have been determined. fluorescence the charge-shift states is significantly enhanced because retardation nonradiative pathways for back-electron transfer. Changes more than 3 orders magnitude back-electron-transfer rates (sucrose vs conventional solvents at room temperature) were observed. Transient spectra displayed long-lived species microsecond time regime thianthrene...
As electrostatic equivalents of magnets, organic electrets offer unparalleled properties for impacting energy conversion and electronic applications. While biological systems have evolved to efficiently utilize protein α-helices as molecular electrets, the synthetic counterparts these conjugates still remain largely unexplored. This paper describes a study anthranilamide oligomers, which proved be based on their intrinsic dipole moments evident from spectral dielectric properties. NMR...