A5042699730- Supramolecular Self-Assembly in Materials
- Synthesis and Properties of Aromatic Compounds
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Modular Robots and Swarm Intelligence
- DNA and Biological Computing
- Nerve injury and regeneration
- Polydiacetylene-based materials and applications
- Chemical Synthesis and Analysis
- Surface Chemistry and Catalysis
- Wound Healing and Treatments
- Antimicrobial Peptides and Activities
- Liquid Crystal Research Advancements
- Dendrimers and Hyperbranched Polymers
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Photochromic and Fluorescence Chemistry
- Glycosylation and Glycoproteins Research
- Neurogenesis and neuroplasticity mechanisms
- Enzyme Catalysis and Immobilization
- Antimicrobial agents and applications
- Pluripotent Stem Cells Research
- Supramolecular Chemistry and Complexes
- Microtubule and mitosis dynamics
Shanghai Jiao Tong University
2021-2025
Revascularization plays a critical role in the healing of diabetic wounds. Accumulation advanced glycation end products (AGEs) and refractory multidrug resistant bacterial infection are two major barriers to revascularization, directly leading impaired Here, an artfully designed chiral gel dressing is fabricated (named as HA-LM2-RMR), which consists l-phenylalanine cationic hexapeptide coassembled helical nanofibers cross-linked with hyaluronic acid via hydrogen bonding. This possesses...
Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. This report discusses biomimetic dextral hydrogel (DH) with right-handed nanofibers that specifically reprograms lipid metabolism NSCs, promoting their differentiation and rapid damaged axons. The underlying mechanism is intrinsic stereoselectivity between DH fatty acid-binding protein 5...
Self-sorting by supramolecular assembly involving homochiral building blocks is of vital importance in life systems, which allows the coexistence multiple species an orthogonal complex mixture to achieve respective biological functions simultaneously. However, self-sorting chiral molecules, typically remains a challenge artificial limiting function development materials. Herein, we report self-sorted hydrogel network formed two l-phenylalanine derivatives, LPPF and LPFA, independently...
Abstract Kinetic co‐assembly pathway induced chirality inversion along with morphology transition is of importance to understand biological processes, but still remains a challenge realize in artificial systems. Herein, helical nanofibers consisting phenylalanine‐based enantiomers (L/DPF) successfully transform into kinetically trapped architectures opposite helicity through kinetic pathway. By contrast, the co‐assemblies obtained by thermodynamic exhibit non‐helical structures. The...
The induction of diverse chirality regulation in nature by multiple binding sites biomolecules is ubiquitous and plays an essential role determining the biofunction biosystems. However, mimicking this biological phenomenon understanding at a molecular level its mechanism with establishing artificial system still remains challenge. Herein, abundant inversion achieved precisely multiply manipulating co-assembled phenylalanine derivatives (D/LPPF) different naphthalene (NA, NC, NP, NF). amide...
The Schwann cell (SC) is essential in peripheral nerve regeneration by reprogramming into a stem-like "repair cell" (rSC) phenotype; however, maintaining the rSC stemness remains an unmet challenge. Chirality fundamental factor controlling fate, and its potential role regulation of SC has long been ignored poorly understood. Herein, inspired natural chiral components microenvironment, hydrogel conduits are prepared supramolecular assembly l/d-phenylalanine derivatives (l/d-Phe) polymeric...
How the three-dimensional (3D) chiral environment affects biocatalysis remains an important issue, thereby inspiring development of a microenvironment that highly mimics natural features enzyme to guarantee enhanced biocatalysis. In this study, two gelators bearing d/l-phenylalanine as centers are designed construct 3D catalytic for enhancing lipase. Such is programmed through transmission chirality from molecular achiral polymers. It shows evidently influences efficiency immobilized lipase...
Open AccessCCS ChemistryRESEARCH ARTICLE5 Aug 2022Biphenyl-Induced Superhelix in l-Phenylalanine-Based Supramolecular Self-Assembly with Dynamic Morphology Transitions Laiben Gao, Yueyue Feng, Chao Xing, Yu Zhao, Meng Sun, Yunqing Zou, Changli Xiaoqiu Dou and Chuanliang Feng Gao State Key Lab of Metal Matrix Composites, School Materials Science Engineering, Shanghai Jiao Tong University, 200240 , College Chemistry Science, Normal 200234 Xing Zhao Zhengzhou 450001 Sun Zou *Corresponding...
Chiral inversion of supramolecular assemblies is great research interest due to its broad practical applications. However, chiral structure transition induced by in situ regulation building molecules has remained a challenge. Herein, left-handed fibrous were constructed C2-symmetic l-phenylalanine coupled with diethylene glycol (LPFEG) molecules. In hydrolyzing terminal motifs LPFEG successfully inverted the chirality nanofibers from left- right-handedness. The right-handed fibers into could...
Abstract The induction of diverse chirality regulation in nature by multiple binding sites biomolecules is ubiquitous and plays an essential role determining the biofunction biosystems. However, mimicking this biological phenomenon understanding at a molecular level its mechanism with establishing artificial system still remains challenge. Herein, abundant inversion achieved precisely multiply manipulating co‐assembled phenylalanine derivatives (D/LPPF) different naphthalene (NA, NC, NP,...
The synergetic evolution of multiple chiral structures stemmed from same building units is ubiquitous in nature and vital to living systems, but achieving it artificial systems remains a challenge. Herein, we report methanol-water mediated dual assembly pathway strategy for simultaneous construction P M helices one-component system. conformation l-phenylaniline derivates (LBpyF) controlled folded state CH3OH due the hydrogen bonds as well C-H···π interaction between LBpyF CH3OH. Addition H2O...
The synergetic evolution of multiple chiral structures stemmed from same building units is ubiquitous in nature and vital to living systems, but achieving it artificial systems remains a challenge. Herein, we report methanol‐water mediated dual assembly pathway strategy for simultaneous construction P M helices one‐component system. conformation l‐phenylaniline derivates (LBpyF) controlled folded state CH3OH due the hydrogen bonds as well C‐H···π interaction between LBpyF CH3OH. Addition H2O...
Chirality evolution is ubiquitous and important in nature, but achieving it artificial systems still challenging. Herein, the chirality of supramolecular helices based on l-phenylalanine derivative (LPF) naphthylamide derivate (NDIAPY) achieved by strategy electron transfer (ET) assisted secondary nucleation. ET from LPF to NDIAPY can be triggered 5 s UV irradiation left-handed LPF-NDIAPY co-assemblies, leading radical anions partial disassembly helices. Meanwhile, spontaneous reversion into...
Abstract Hypoxic injury poses a severe threat to cell survival. Activation of pro‐survival autophagy via autophagy‐inducing nanomaterials (AINMs) has emerged as one the most promising therapeutic strategies. However, internalized AINMs easily bind with intracellular lysosomes, resulting in disruptive effects on autophagic flux and limited effects. Herein, inspired by naturally existing chiral structures actin membrane protein, two nanofibers based achiral pyridine‐substituted coumarin...
Abstract Kinetic co‐assembly pathway induced chirality inversion along with morphology transition is of importance to understand biological processes, but still remains a challenge realize in artificial systems. Herein, helical nanofibers consisting phenylalanine‐based enantiomers (L/DPF) successfully transform into kinetically trapped architectures opposite helicity through kinetic pathway. By contrast, the co‐assemblies obtained by thermodynamic exhibit non‐helical structures. The...