A5100732420- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- RNA Research and Splicing
- Genetic Associations and Epidemiology
- Supramolecular Self-Assembly in Materials
- Congenital heart defects research
- interferon and immune responses
- Epigenetics and DNA Methylation
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Genetic and Kidney Cyst Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Nuclear Structure and Function
- Renal cell carcinoma treatment
- Corneal surgery and disorders
- Glioma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Genetic and phenotypic traits in livestock
Shanghai Jiao Tong University
2020-2025
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
McDermott International (United States)
2008-2025
Hebei University
2025
Shanghai Ninth People's Hospital
2025
Wenzhou Medical University
2013-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2013-2024
Fuzhou University
2024
Minjiang University
2024
Idiopathic pulmonary fibrosis (IPF) is an adult-onset, lethal, scarring lung disease of unknown etiology. Some individuals with IPF have a familial disorder that segregates as dominant trait incomplete penetrance. Here we used linkage to map the gene in two families chromosome 5. Sequencing candidate within interval, TERT , revealed missense mutation and frameshift cosegregated families. encodes telomerase reverse transcriptase, which together RNA component ( TERC ), required maintain...
Heterozygous mutations in the coding regions of telomerase genes, TERT and TERC, have been found familial sporadic cases idiopathic interstitial pneumonia. All affected patients with short telomeres.
Excess hepatic storage of triglycerides is considered a benign condition, but nonalcoholic steatohepatitis (NASH) may progress to fibrosis and promote atherosclerosis. Carriers the TM6SF2 E167K variant have fatty liver as result reduced secretion very-low-density lipoproteins (VLDLs). As result, they lower circulating lipids risk myocardial infarction. In this study, we aimed assess whether affects damage cardiovascular outcomes in subjects at NASH. Liver was evaluated 1,201 patients who...
Background Telomerase is an enzyme that catalyzes the addition of nucleotides on ends chromosomes. Rare loss function mutations in gene encodes protein component telomerase (TERT) have been described patients with idiopathic pulmonary fibrosis (IPF). Here we examine telomere lengths and phenotype seen multiple kindreds heterozygous TERT mutations. Methods Findings We identified 134 individuals from 21 unrelated families. Available medical records, surgical lung biopsies radiographs were...
Dermal adipose tissue (also known as dermal white and herein referred to dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate mature adipocytes origin rapidly reappearing at different stages remain unclear. Here, we isolated characterized fat cellular molecular level. Together with dWAT's dynamic responses external stimuli, established that are a distinct class high plasticity. By combining pulse-chase lineage tracing single-cell...
Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here, we identified hitherto uncharacterized hypoxia-induced lncRNA RAB11B-AS1 cells. is natural upregulated human and its expression induced by hypoxia-inducible factor 2 (HIF2), not HIF1, response to hypoxia. enhanced the angiogenic factors including VEGFA ANGPTL4 hypoxic cells increasing recruitment RNA polymerase II. In line with increased factors,...
Revascularization plays a critical role in the healing of diabetic wounds. Accumulation advanced glycation end products (AGEs) and refractory multidrug resistant bacterial infection are two major barriers to revascularization, directly leading impaired Here, an artfully designed chiral gel dressing is fabricated (named as HA-LM2-RMR), which consists l-phenylalanine cationic hexapeptide coassembled helical nanofibers cross-linked with hyaluronic acid via hydrogen bonding. This possesses...
Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of in BCSCs remains unclear. We recently found that histone reader ZMYND8 was upregulated BCSCs. Here, we showed reduced ROS iron inhibit ferroptosis aldehyde dehydrogenase–high (ALDHhi) BCSCs, leading BCSC expansion tumor initiation mice. The underlying involved a two-fold posttranslational regulation nuclear factor erythroid 2–related 2 (NRF2). increased...
Altered epigenetic reprogramming contributes to breast cancer progression and metastasis. How the reader mediates remains poorly understood. Here, we showed that zinc finger MYND-type containing 8 (ZMYND8) is induced by HIF-1 HIF-2 in cells also upregulated human tumors, correlated with poor survival of patients cancer. Genetic deletion ZMYND8 decreases cell colony formation, migration, invasion vitro, inhibits tumor growth metastasis lungs mice. The ZMYND8's oncogenic effect requires HIF-2....
Abstract Renal cell carcinoma (RCC) clusters in some families. Familial RCC arises from mutations several genes, including the von Hippel-Lindau (VHL) tumor suppressor, which is also mutated sporadic RCC. However, a significant percentage of familial remains unexplained. Recently, we discovered that BRCA1-associated protein-1 (BAP1) gene The BAP1 encodes nuclear deubiquitinase and appears to be classic two-hit suppressor gene. Somatic are associated with high-grade, clear-cell (ccRCC) poor...