Christopher J. Ricketts
A5089457536- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Cancer-related gene regulation
- Genetic and Kidney Cyst Diseases
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Adrenal and Paraganglionic Tumors
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Hematopoietic Stem Cell Transplantation
- Tuberous Sclerosis Complex Research
- Cancer Mechanisms and Therapy
- Cytomegalovirus and herpesvirus research
- Pancreatic function and diabetes
- Medical Imaging and Pathology Studies
National Cancer Institute
2016-2025
Center for Cancer Research
2015-2024
National Institutes of Health
2014-2024
Memorial Sloan Kettering Cancer Center
2018-2019
Accreditation Council for Graduate Medical Education
2019
ORCID
2018
Mayo Clinic in Florida
2018
Molecular Oncology (United States)
2008-2018
Memorial University of Newfoundland
2016
University of Kentucky
2015
Papillary renal-cell carcinoma, which accounts for 15 to 20% of carcinomas, is a heterogeneous disease that consists various types renal cancer, including tumors with indolent, multifocal presentation and solitary an aggressive, highly lethal phenotype. Little known about the genetic basis sporadic papillary no effective forms therapy advanced exist.We performed comprehensive molecular characterization 161 primary using whole-exome sequencing, copy-number analysis, messenger RNA microRNA...
Simple criteria are needed to predict which patients with severe ulcerative colitis will respond poorly intensive medical treatment and require colectomy.To find out if the early pattern of change in inflammatory markers or other variables could need for surgery evaluate outcome during one year follow up.51 consecutive episodes (Truelove Witts criteria) affecting 49 admitted John Radcliffe Hospital, Oxford.Prospective study monitoring 36 clinical, laboratory, radiographic variables. All...
To elucidate the deregulated functional modules that drive clear cell renal carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration proteogenomic measurements uniquely protein dysregulation cellular mechanisms impacted by alterations, including...
Familial renal cell carcinoma (RCC) is a heterogeneous disorder that most commonly caused by germline mutations in the VHL , MET and FLCN genes or constitutional chromosome 3 translocations. However, for many patients with familial RCC, genetic basis of disease undefined. We investigated whether fumarate hydratase ( FH ) succinate dehydrogenase subunit SDHB SDHC SDHD were associated RCC susceptibility 68 no clinical evidence an syndrome. No identified probands, but (4.4%) probands had...
Succinate dehydrogenase B (SDHB) and D (SDHD) subunit gene mutations predispose to adrenal extraadrenal pheochromocytomas, head neck paragangliomas (HNPGL), other tumor types. We report risks in 358 patients with SDHB (n=295) SDHD (n=63) mutations. Risks of HNPGL pheochromocytoma mutation carriers were 29% 52%, respectively, at age 60 years 71% 29%, carriers. malignant renal tumors (14% 70 years) higher carriers; 55 different (including a novel recurrent exon 1 deletion) identified. No clear...
No AccessJournal of UrologyAdult Urology1 Dec 2012Succinate Dehydrogenase Kidney Cancer: An Aggressive Example the Warburg Effect in Cancer Christopher J. Ricketts, Brian Shuch, Cathy D. Vocke, Adam R. Metwalli, Gennady Bratslavsky, Lindsay Middelton, Youfeng Yang, Ming-Hui Wei, Stephen E. Pautler, James Peterson, Catherine A. Stolle, Berton Zbar, Maria Merino, Laura S. Schmidt, Peter Pinto, Ramaprasad Srinivasan, Karel Pacak, and W. Marston Linehan RickettsChristopher Ricketts Urologic...
Clear cell renal carcinomas (ccRCCs) represent ∼75% of RCC cases and account for most RCC-associated deaths. Inter- intratumoral heterogeneity (ITH) results in varying prognosis treatment outcomes. To obtain the comprehensive profile ccRCC, we perform integrative histopathologic, proteogenomic, metabolomic analyses on 305 ccRCC tumor segments 166 paired adjacent normal tissues from 213 cases. Combining histologic molecular profiles reveals ITH 90% ccRCCs, with 50% demonstrating immune...
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying significant cis-effects and distal trans-effects quantified at RNA, protein, phosphoprotein levels. Salient observations include association point mutations copy-number alterations with rewiring protein interaction networks,...
<h3>Context</h3> Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest–derived neoplasms. We recently identified germline mutations of the novel transmembrane-encoding gene<i>FP/TMEM127</i>in familial sporadic pheochromocytomas consistent with a tumor suppressor effect. <h3>Objectives</h3> To examine prevalence spectrum of<i>FP/TMEM127</i>mutations in to test effect vitro. <h3>Design, Setting, Participants</h3> sequenced the<i>FP/TMEM127</i>gene 990 individuals...
S ummary . Plasma concentrations of desferrioxamine and ferrioxamine were measured following bolus injections during 24 h infusions the drug. [ 59 Fe]ferrioxamine clearance urinary iron excretion also measured. Higher plasma are found in loaded subjects higher with normal loads. There is a correlation between circulating concentration an infusion 48 excretion. The data suggests that amount chelated vivo related to increase size intermediate chelatable pool rather than total load....
Purpose Approximately 5% to 8% of renal cell carcinoma (RCC) is hereditary. No guidelines exist for patient selection RCC germline mutation testing. We evaluate how age onset could indicate the need testing detection inherited forms kidney cancer. Patients and Methods analyzed distribution cases in SEER-17 program our institutional hereditary cancer population. The distributions were compared by sex, race, histology, syndrome. Models established specific thresholds genetic Results median...
Abstract Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve prognosis and treatment advanced cancer patients. In this study, we performed a genome-wide profile DNA methylation patterns in sporadic breast tumors by using the HumanMethylation27 BeadChips assess relationships between changes patient characteristics. The arrays identified 264 hypermethylated loci/genes present genomic CpG islands. Hierarchical clustering based on levels divided specimens...
Abstract Renal cell carcinoma (RCC) clusters in some families. Familial RCC arises from mutations several genes, including the von Hippel-Lindau (VHL) tumor suppressor, which is also mutated sporadic RCC. However, a significant percentage of familial remains unexplained. Recently, we discovered that BRCA1-associated protein-1 (BAP1) gene The BAP1 encodes nuclear deubiquitinase and appears to be classic two-hit suppressor gene. Somatic are associated with high-grade, clear-cell (ccRCC) poor...
Mutations in the Fe-S cluster-containing SDHB subunit of succinate dehydrogenase cause familial cancer syndromes. Recently tripeptide motif L(I)YR was identified recipient protein SDHB, to which cochaperone HSC20 binds. In order characterize metabolic basis SDH-deficient cancers we performed stable isotope-resolved metabolomics a novel SDHB-deficient renal cell carcinoma line and conducted bioinformatics biochemical screening analyze cluster acquisition assembly SDH presence other...
No AccessJournal of UrologyAdult Urology1 Dec 2013Germline PTEN Mutation Cowden Syndrome: An Underappreciated Form Hereditary Kidney Cancer Brian Shuch, Christopher J. Ricketts, Cathy D. Vocke, Takefumi Komiya, Lindsay A. Middelton, Eric C. Kauffman, Maria Merino, Adam R. Metwalli, Phillip Dennis, and W. Marston Linehan ShuchBrian Shuch Urologic Oncology Branch, Center for Research, National Institute, Institutes Health, Bethesda, Maryland , RickettsChristopher Ricketts VockeCathy Vocke...