A5005644998- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Estrogen and related hormone effects
- Chronic Lymphocytic Leukemia Research
- ATP Synthase and ATPases Research
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Bladder and Urothelial Cancer Treatments
- Luminescence Properties of Advanced Materials
- Cancer, Stress, Anesthesia, and Immune Response
- Quantum Dots Synthesis And Properties
- Prostate Cancer Treatment and Research
Baylor College of Medicine
2016-2025
Dan L Duncan Comprehensive Cancer Center
2016-2024
Weatherford College
2024
Children's Cancer Center
2009-2022
Houston Methodist
2015
Rice University
2012
Council of Scientific and Industrial Research
2012
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
2010
University of Tübingen
2008-2010
Robert Bosch (Germany)
2008
Graphene quantum dots (GQDs), which are edge-bound nanometer-size graphene pieces, have fascinating optical and electronic properties. These been synthesized either by nanolithography or from starting materials such as oxide (GO) the chemical breakdown of their extended planar structure, both multistep tedious processes. Here, we report that during acid treatment exfoliation traditional pitch-based carbon fibers, cheap commercially available, stacked graphitic submicrometer domains fibers...
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation copy number, RNA, protein expression), we classified 894 renal cell carcinomas (RCCs) various histologic types into nine major genomic subtypes. Site origin within nephron was one determinant in classification, reflecting differences among clear cell, chromophobe, papillary RCC. Widespread changes associated with TFE3 gene fusion or chromatin modifier genes were present a specific...
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial reprogramming mitochondria-regulated cancer pathways in triple-negative breast (TNBC). Analysis of established (BC) cell lines showed that metastatic TNBC maintains high levels ATP through fatty acid β oxidation (FAO) activates Src oncoprotein autophosphorylation at Y419. Manipulation FAO including the knocking down carnitine palmitoyltransferase-1A (CPT1) 2 (CPT2), rate-limiting proteins FAO,...
Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis metastasis. However, it is still largely unknown how orchestrate gene regulation balance OXPHOS activities. Previously, by modeling the of we have reported that can acquire a stable hybrid metabolic state in which both be used. Here, comprehensively characterize activity, establish theoretical framework coupling with pathways. Our...
Abnormal metabolism is a hallmark of cancer, yet its regulation remains poorly understood. Cancer cells were considered to utilize primarily glycolysis for ATP production, referred as the Warburg effect. However, recent evidence suggests that oxidative phosphorylation (OXPHOS) plays crucial role during cancer progression. Here we utilized systems biology approach decipher regulatory principle and OXPHOS. Integrating information from literature, constructed network genes metabolites, which...
The unfolded protein response (UPR) is a cellular homeostatic mechanism that activated in many human cancers and plays pivotal roles tumor progression therapy resistance. However, the molecular mechanisms for UPR activation regulation cancer cells remain elusive. Here, we show oncogenic MYC regulates inositol-requiring enzyme 1 (IRE1)/X-box binding (XBP1) branch of breast via multiple mechanisms. We found directly controls IRE1 transcription by to its promoter enhancer. Furthermore, forms...
Highlights•Biguanides activate or suppress TNBC progression in a dose-dependent manner•Biguanides regulate c-Src by the antithetical regulation of AMPK-FAO•Combination dasatinib with metformin suppresses and metastasisSummaryThe biguanide attenuates mitochondrial oxidation is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation fatty acid β-oxidation (FAO) subgroup patients breast cancer (BC) after Considering that FAO can Src kinase aggressive...
Estrogen receptor α (ERα) plays an important role in the onset and progression of breast cancer, whereas p53 functions as a major tumor suppressor. We previously reported that ERα binds to p53, resulting inhibition transcriptional regulation by p53. Here, we report on molecular mechanisms which suppresses p53’s transactivation function. Sequential ChIP assays demonstrated represses p53-mediated activation human cancer cells recruiting nuclear corepressors (NCoR SMRT) histone deacetylase 1...
Mitochondrial-nucleus cross talks and mitochondrial retrograde regulation can play a significant role in cellular properties. Transmitochondrial cybrid systems (cybrids) are an excellent tool to study specific effects of altered mitochondria under defined nuclear background. The majority the studies using model focused on significance DNA variations function or tumor However, most these variants benign polymorphisms without known functional significance. From objective rectifying defects...
Abstract The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 ( GNPNAT1 ) is found significantly decreased CRPC compared with localized (PCa). Genetic loss-of-function CRPC-like cells increases proliferation and...
Despite altered metabolism being an accepted hallmark of cancer, it is still not completely understood which signaling pathways regulate these processes. Given the central role androgen receptor (AR) in prostate we hypothesized that AR could promote cancer cell growth part through increasing glucose uptake via expression distinct transporters. Here, determined directly increased SLC2A12 , gene encodes transporter GLUT12. In support findings, signatures activity correlated with multiple...
A biocompatible hybrid 2D nanomaterial based on graphene oxide and superparamagnetic Fe3O4 is demonstrated as a multimodality contrast enhancement agent for cellular imaging using photoluminescence magnetic resonance imaging. This provides the possibility to use and/or multitasking agents biomedical applications. Detailed facts of importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted...
Herein we have established a strategy for the synthesis of highly luminescent and biocompatible europium-doped lanthanum orthophosphate (La0.85PO4Eu0.153+) nanorods. The structure morphogenesis these nanorods been probed by XRD, SEM, TEM/HRTEM techniques. XRD result confirms that as-synthesized form in monazite phase with monoclinic crystal structure. Furthermore, surface morphology shows synthesized an average diameter ∼90 nm length ∼2 μm. HRTEM images show clear lattice fringes support...
Abstract Smoking is a major risk factor for the development of bladder cancer; however, functional consequences carcinogens in tobacco smoke and cancer–associated metabolic alterations remain poorly defined. We assessed profiles cancer smokers non-smokers identified key their metabolism. LC/MS bioinformatic analysis were performed to determine metabolome associated with further validated cell line models. Smokers found have elevated levels methylated metabolites, polycyclic aromatic...
Abstract Background Anti-tumorigenic vs pro-tumorigenic roles of estrogen receptor-beta (ESR2) in breast cancer remain unsettled. We investigated the potential TP53 status to be a determinant bi-faceted role ESR2 and associated therapeutic implications for triple negative (TNBC). Methods ESR2-TP53 interaction was analyzed with multiple assays including situ proximity ligation assay. Transcriptional effects on TP53-target genes cell proliferation response knocking down or overexpressing were...
Abstract Background Intestinal epithelial cell (IEC) mitochondrial dysfunction involvement in inflammatory bowel diseases (IBD), including Crohn’s disease affecting the small intestine, is emerging recent studies. As interface between self and gut microbiota, IECs serve as hubs of bidirectional cross-talk host luminal microbiota. However, role mitochondrial-microbiota interaction ileum largely unexplored. Prohibitin 1 (PHB1), a chaperone protein inner membrane required for optimal electron...
Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, poor solubility off-target activity have limited utility in clinical trials. Additionally, the immune modulatory role of betulinic analogue tumor microenvironment (TME) is largely unknown. Here, we designed a potential nanotherapy colorectal cancer (CRC) with lead analogue, named as 2c, carrying 1,2,3-triazole-moiety attached to...
Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared with European (EA) patients, but the molecular mechanism underlying race-specific differences are unknown. To address this gap, we conducted comprehensive RNA-Seq, proteomics, and metabolomics analysis of BLCA tumors from AA EA. Our findings reveal a distinct metabolic phenotype characterized by elevated mitochondrial oxidative phosphorylation (OXPHOS), particularly through activation complex I. The results...