A5082037761- Iron Metabolism and Disorders
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Erythropoietin and Anemia Treatment
- Metal complexes synthesis and properties
- RNA regulation and disease
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Ionosphere and magnetosphere dynamics
- Geophysics and Gravity Measurements
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
Institut Européen De La Qualité Totale
2024
Wake Forest University
2006-2023
UConn Health
2014-2023
University of Connecticut
2012-2021
Virginia Commonwealth University
2015
Jackson Laboratory
2015
Magna Graecia University
2015
Farmington Community Library
2014
University of Otago
2011
Karolinska Institutet
2011
Ferritin is a spherical molecule composed of 24 subunits two types, ferritin H chain (FHC) and L (FLC). stores iron within cells, but it also circulates binds specifically saturably to variety cell types. For most this binding can be mediated by only FHC (HFt) not FLC (LFt), indicating that cells FLC. By using expression cloning, we identified human transferrin receptor-1 (TfR1) as an important receptor for HFt with little or no LFt. In vitro, precipitated soluble TfR1, showing interaction...
Iron is required for normal cell growth and proliferation. However, excess iron potentially harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton chemistry. For this reason, cells have evolved highly regulated mechanisms controlling intracellular levels. Chief among these sequestration in ferritin. Ferritin a 24 subunit protein composed two types, termed H L. The ferritin has potent ferroxidase activity that catalyses oxidation ferrous iron, whereas L...
An iron efflux pump is a pivotal protein in breast cancer biology and strong independent predictor of prognosis.
Ferroportin and hepcidin are critical proteins for the regulation of systemic iron homeostasis. is only known mechanism export intracellular non–heme-associated iron; its stability regulated by hormone hepcidin. Although ferroportin profoundly affects concentrations in tissues important absorption trafficking, breast cancer their influence on growth prognosis have not been examined. We demonstrate here that both expressed cultured human epithelial cells regulates these cells. Further,...
Multiwalled carbon nanotubes (MWCNTs) exhibit physical properties that render them ideal candidates for application as noninvasive mediators of photothermal cancer ablation. Here, we demonstrate use MWCNTs to generate heat in response near-infrared radiation (NIR) results thermal destruction kidney vitro and vivo. We document the effects therapy through magnetic resonance temperature-mapping shock protein-reactive immunohistochemistry. Our enables ablation tumors with low laser powers (3...
Iron is required for normal cell growth and proliferation. However, excess iron potentially harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton chemistry. For this reason, cells have evolved highly regulated mechanisms controlling intracellular levels. Chief among these sequestration in ferritin. Ferritin a 24 subunit protein composed two types, termed H L. The ferritin has potent ferroxidase activity that catalyses oxidation ferrous iron, whereas L...
Ferritin is a ubiquitous and highly conserved protein which plays major role in iron homeostasis. We have identified sequenced full-length cDNA for murine ferritin heavy chain. The isolated 819 nucleotides length. It includes 546 encode of 182 amino acids, 5′ noncoding sequence 120 nucleotides, 3′-noncoding region 153 nucleotides. displays high degree homology to human H, portion the iron-responsive element chick, frog, ferritin. Tumor necrosis factor (TNF), cytokine mediates elements stress...
The global increase in transcription of cytoprotective genes induced response to oxidative challenge has been termed the antioxidant response. Ferritin serves as major iron-binding protein nonhematopoietic tissues, limiting catalytic availability iron for participation oxygen radical generation. Here we demonstrate that ferritin is a participant through genetically defined electrophile element (EpRE). EpRE H identified this report exhibits sequence similarity motifs found such those encoding...
Ferritin is a ubiquitous intracellular iron storage protein that consists of 24 subunits the H and L type. The ability to sequester from participation in oxygen free radical formation consistent with cytoprotective role for ferritin. Here we demonstrate ferritins are induced cells treated β-napthoflavone (β-NF) chemopreventive dithiolethiones. Induction ferritin by β-NF dithiolethiones oltipraz 1,2-dithiole-3-thione (D3T) occurs via transcriptional mechanism mediated...
The anthracycline antibiotic doxorubicin produces a characteristic myopathy in cardiac muscle that limits its use cancer therapy. We have shown cultured neonatal rat cells treatment resulted rapid, selective decrease the expression of muscle-specific genes, which preceded other changes cardiomyopathy. Doxorubicin selectively and dramatically decreased levels mRNA for sarcomeric alpha-actin, troponin I, myosin light chain 2, as well muscle-specific, but nonsarcomeric M isoform creatine...
This study demonstrates the capability of multiwalled carbon nanotubes (MWNTs) coupled with laser irradiation to enhance treatment cancer cells through enhanced and more controlled thermal deposition, increased tumor injury, diminished heat shock protein (HSP) expression. We also explored potential promise MWNTs as drug delivery agents by observing degree intracellular uptake these nanoparticles. To determine generation MWNTs, absorption spectra temperature rise during heating were measured....