A5045069219- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Plant biochemistry and biosynthesis
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Graphene research and applications
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- ATP Synthase and ATPases Research
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Flavonoids in Medical Research
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Connective Tissue Growth Factor Research
- Multiple Myeloma Research and Treatments
- Cancer-related Molecular Pathways
- Gas Sensing Nanomaterials and Sensors
Dakota State University
2022-2025
North Dakota State University
2020-2025
Baylor College of Medicine
2022-2025
Dana-Farber Cancer Institute
2023-2025
Harvard University
2023-2025
Jadavpur University
2016-2024
National Institute of Mental Health and Neurosciences
2023
Gauhati Medical College and Hospital
2017
Indian Institute of Chemical Biology
2015-2016
National Institute of Biomedical Genomics
2013
Gingivo-buccal oral squamous cell carcinoma (OSCC-GB), an anatomical and clinical subtype of head neck (HNSCC), is prevalent in regions where tobacco-chewing common. Exome sequencing (n=50) recurrence testing (n=60) reveals that some significantly frequently altered genes are specific to OSCC-GB (USP9X, MLL4, ARID2, UNC13C TRPM3), while others shared with HNSCC (for example, TP53, FAT1, CASP8, HRAS NOTCH1). We also find new recurrent amplifications DROSHA, YAP1) or homozygous deletions...
Highlights•Biguanides activate or suppress TNBC progression in a dose-dependent manner•Biguanides regulate c-Src by the antithetical regulation of AMPK-FAO•Combination dasatinib with metformin suppresses and metastasisSummaryThe biguanide attenuates mitochondrial oxidation is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation fatty acid β-oxidation (FAO) subgroup patients breast cancer (BC) after Considering that FAO can Src kinase aggressive...
Pancreatic ductal adenocarcinoma (PDAC), a metabolic disorder, remains one of the leading cancer mortality sources worldwide. An initial response to treatments, such as gemcitabine (GEM), is often followed by emergent resistance reflecting an urgent need for alternate therapies. The PDAC GEM could be due ERK1/2 activity. However, successful ERKi therapy hindered low ligand efficiency, poor drug delivery, and toxicity. In this study, overcome these limitations, we have designed pH-responsive...
Abstract Betulinic acid, a plant secondary metabolite, has gained significant attention due to its antiproliferative activity over range of cancer cells. A promising betulinic acid analogue ( 2c ) with better therapeutic efficacy than parent molecule colon carcinoma cells been reported. Despite impressive biological applications, low aqueous solubility and bioavailability create difficulties for applications. To overcome these lacunae make it as drug candidate we have encapsulated the lead...
The molecular architecture of pH-responsive amphiphilic block copolymers, their self-assembly behavior to form nanoparticles (NPs), and doxorubicin (DOX)-loading technique govern the extent DOX-induced cardiotoxicity. We observed that choice pH-sensitive tertiary amines, surface charge, DOX-loading techniques within self-assembled NPs strongly influence release stimulation cardiotoxicity in primary cardiomyocytes. However, covalent conjugation DOX a nanocarrier through "conditionally...
Hepatocellular carcinoma (HCC) is a leading cause of death globally. Even though the progressive invention some very potent therapeutics has been seen, success limited due to chemotherapeutic resistance and recurrence in HCC. Advanced targeted treatment options like immunotherapy, molecular therapy or surface-engineered nanotherapeutics could offer benefits here owing drug over tumor heterogenicity. We have developed tumor-sensing phosphorothioate amino-modified aptamer (AS1411)-conjugated...
Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, poor solubility off-target activity have limited utility in clinical trials. Additionally, the immune modulatory role of betulinic analogue tumor microenvironment (TME) is largely unknown. Here, we designed a potential nanotherapy colorectal cancer (CRC) with lead analogue, named as 2c, carrying 1,2,3-triazole-moiety attached to...
Apigenin has gained interest recently among researchers as a potential chemotherapeutic agent in cancer, including colorectal due to its established antiproliferative activity vitro. Despite impressive anticancer vitro, poor water solubility and nonspecific distribution vivo make it difficult for emergence drug candidate. To overcome these problems, we formulated an aptamer-conjugated apigenin-loaded nanoparticle (apt-ANP) target against the overexpressed cancer cell surface biomarker...
Background and objective: Targeted drug delivery of nanoparticles decorated with site-specific recognition ligands is considerable interest to minimize cytotoxicity chemotherapeutics in the normal cells. The study was designed develop CD-340 antibody-conjugated polylactic-co-glycolic acid (PLGA) loaded a highly water-soluble potent anticancer drug, doxorubicin (DOX), specifically deliver entrapped DOX breast cancer Methods: showed how incorporate hydrophobic PLGA (85:15) based matrix which...
Epigallocatechin-3-gallate (EGCG) has been considered an anticancer agent despite conflicting and discrepant bioavailability views. EGCG impairs the viability self-renewal capacity of triple-negative breast cancer (TNBC) cells makes them sensitive to estrogen via activating ER-α. Surprisingly, mechanism EGCG's action on TNBC remains unclear. CCN5/WISP-2 is a gatekeeper gene that regulates viability, ER-α, stemness in other types cancers. This study aimed investigate whether (free or...
Betulinic acid (BA), a member of pentacyclic triterpenes has shown important biological activities like anti-bacterial, anti-malarial, anti-inflammatory and most interestingly anticancer property. To overcome its poor aqueous solubility low bioavailability, structural modifications functional groups are made to generate novel lead(s) having better efficacy less toxicity than the parent compound. BA analogue, 2c was found potent inhibitor colon cancer cell line, HT-29 cells with IC50 value...
Background and Purpose: Epigallocatechin-3-gallate (EGCG) has been considered an anticancer agent despite conflicting discrepant bioavailability views. EGCG impairs the viability self-renewal capacity of triple-negative breast cancer (TNBC) cells makes them sensitive to estrogen via activating ER-α. Surprisingly, mechanism EGCG’s action on TNBC remains unclear. CCN5/WISP-2 is a gatekeeper gene that regulates viability, ER-α, stemness in other types cancers. This study aimed investigate...
Abstract Bortezomib (BTZ) is a standard-of-care treatment in multiple myeloma (MM); however, adverse side effects and development of resistance limit its long term benefit. To improve target specificity, therapeutic efficacy, overcome resistance, we designed nanoparticles that encapsulate BTZ are surface-functionalized with BCMA antibodies (BCMA-BTZ-NPs). We confirmed efficient cellular internalization the BCMA-BTZ-NPs only BCMA-expressing MM cells, but not BCMA-knockout (KO) cells. In...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources cancer mortality worldwide, including US Veterans. An initial response to chemotherapy, such as Gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed by emergent resistance, reflecting an urgent need for targeted therapies. PDAC cells are highly addicted oncogenic K-RAS mutations their growth, progression, immunosuppression, and drug but mutant still tricky target. A...
Epigenetic enzyme-responsive nanoparticles (ERPs), which destabilize under the influence of histone deacetylase 8 (HDAC8), have been characterized in terms their physicochemical, nanomechanical, and vitro attributes. These were synthesized from amphiphilic block copolymers composed poly(acetyl l-lysine) as hydrophobic poly(ethylene glycol) hydrophilic block. Upon optimizing particle assembly process, we demonstrated that nanoscale properties ERPs, including hydrodynamic diameter (DH), size...
Abstract Prostate cancer (PCa) is one of the fatal illnesses among males globally. PCa-treatment does not include radiotherapy. Chemotherapy eventually causes drug resistance, disease recurrence, metastatic advancement, multi-organ failure, and death. Preclinical data on PCa-induced by carcinogens are truly scarce. Although some xenograft-PCa in animals available, they mostly belonged to immuno-compromised animals. Here, we developed ΔPSap4#5 aptamer surface-functionalized abiraterone-loaded...
Drug delivery systems (DDS) that can temporally control the rate and extent of release therapeutically active molecules find applications in many clinical settings, ranging from infection to cancer therapy. With an aim design a locally implantable, controlled-release DDS, we demonstrated feasibility using cellulose nanocrystal (CNC)-reinforced poly (l-lactic acid) (PLA) composite beads. The performance platform was evaluated doxorubicin (DOX) as model drug for triple-negative breast cancer....
Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types aggressive malignancies, are limited and disappointing. Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains first-line chemotherapeutic drug in clinic PDAC treatment. The therapeutic limitations GEM primarily due to poor bioavailability development chemoresistance resulting from addiction mutant-K-RAS/AKT/ERK signaling-mediated desmoplastic barriers with a hypoxic...