Florian Roghmann
A5004532044- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Colorectal Cancer Screening and Detection
- Urinary Bladder and Prostate Research
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Urologic and reproductive health conditions
- Cancer survivorship and care
- Multiple and Secondary Primary Cancers
- Pelvic floor disorders treatments
- Peptidase Inhibition and Analysis
- Urinary Tract Infections Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- Spectroscopy Techniques in Biomedical and Chemical Research
Ruhr University Bochum
2016-2025
Universitätsklinik Marien Hospital Herne
2015-2024
Bridgepoint (Germany)
2022-2024
Weatherford College
2024
Hôpital Bichat-Claude-Bernard
2019
Assistance Publique – Hôpitaux de Paris
2019
Luzerner Kantonsspital
2019
Université Paris Cité
2019
Université Claude Bernard Lyon 1
2019
Hamburg Institut (Germany)
2017
PURPOSE The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit only achieved in a small, yet uncharacterized patient subset. NECTIN4 located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) cancer. Here, we aimed to evaluate amplifications as genomic biomarker predict EV response mUC. MATERIALS AND METHODS We established NECTIN4-specific fluorescence...
To examine postoperative complications in a contemporary series of patients after radical cystectomy using standardized reporting system, and to identify readily available preoperative risk factors.Using the modified Clavien-Dindo classification, we assessed 90-day clinical course 535 bladder cancer who underwent urinary diversion (ileal conduit n = 349, ileal neobladder 186) between June 2003 February 2012 at single institution. All Martin criteria for were met. Uni- multivariable analyses...
Treatment options are limited for patients with high-risk non-muscle-invasive bladder cancer (NMIBC) disease recurrence after bacillus Calmette-Guérin (BCG) treatment and who ineligible for/refuse radical cystectomy. FGFR alterations commonly detected in NMIBC. We evaluated the activity of oral erdafitinib, a selective pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, versus intravesical chemotherapy NMIBC select FGFR3/2 following BCG treatment.
Using the Nationwide Emergency Department Sample (NEDS) we examined trends in visits, hospitalization and charges for patients with upper urinary tract stones who presented to emergency department United States.All visits a primary diagnosis of kidney calculus (ICD-9-CM code 592.0), ureter (592.1) or unspecified (592.9) were extracted from NEDS between 2006 2009. A weighted sample was used calculate incidence rates. Temporal quantified by estimated annual percent change. Patient hospital...
Study Type – Prognosis (prospective cohort) Level of Evidence 2a What's known on the subject? and What does study add? Fournier's gangrene (FG) is a rare but life-threatening disease challenging treating medical staff. Despite fact that antibiotic therapy combined with surgery intensive care surveillance are performed as standard treatment, mortality rates remain high. There have been efforts to develop reliable tool predict severity disease, not only identify patients at highest risk major...
Priapism is a complex medical emergency that often requires prompt management. In this study, we examine the incidence of condition in United States population based setting, and assess patient department attributes associated with an increased likelihood hospitalization.Emergency visits primary diagnosis priapism between 2006 2009 were abstracted from Nationwide Emergency Department Sample. Univariable multivariable analyses performed hospital characteristics those admitted priapism.Between...
We prospectively assessed whether a combined approach of real-time elastography and contrast enhanced ultrasound would improve prostate cancer visualization.Between June 2011 January 2012, 100 patients with biopsy proven underwent preoperative transrectal multiparametric combining ultrasound. After initial elastographic screening for suspicious lesions, defined as blue areas decreased tissue strain, each lesion was allocated to the corresponding sector. The target largest area. Perfusion...
To compare efficacy between radical prostatectomy (RP), radiotherapy and observation with respect to overall survival (OS) in patients clinically localized prostate cancer (PCa).Using data (1988-2005) from the Surveillance, Epidemiology, End Results-Medicare linked database, 67 087 men PCa were identified. The prevalence of initial treatment strategy was quantified according patients' life expectancy ([LE] <10 vs ≥10 years) at diagnosis tumour stage. reduce unmeasured bias associated...
Abstract Smoking is a major risk factor for the development of bladder cancer; however, functional consequences carcinogens in tobacco smoke and cancer–associated metabolic alterations remain poorly defined. We assessed profiles cancer smokers non-smokers identified key their metabolism. LC/MS bioinformatic analysis were performed to determine metabolome associated with further validated cell line models. Smokers found have elevated levels methylated metabolites, polycyclic aromatic...
Robust biomarkers to predict response immune checkpoint blockade (ICB) in metastatic urothelial carcinoma (mUC) are still demand. Recently, early C-reactive protein (CRP) kinetics and especially the novel CRP flare-response phenomenon has been associated with immunotherapy response.We conducted a multicentre observational study comprising 154 patients mUC treated ICB evaluate predictive value of previously described on-treatment kinetics: flare responders (at least doubling baseline within...
Abstract Purpose This study aims to evaluate survival, health-related quality of life (HRQoL), psychosocial distress, and functional outcomes after radical cystectomy (RC) urinary diversion for ileal neobladder (INB) or conduit (IC) in a contemporary German cohort bladder cancer patients. Methods Patients undergoing inpatient rehabilitation RC between April 2018 December 2019 one high-volume center were surveyed regarding HRQoL, until two years RC. Results Eight-hundred forty-two patients...