A5077545940- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Global Cancer Incidence and Screening
- Urological Disorders and Treatments
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Renal and related cancers
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
- Colorectal Cancer Screening and Detection
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Pelvic floor disorders treatments
- Pediatric Urology and Nephrology Studies
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Cancer survivorship and care
- COVID-19 and healthcare impacts
- Colorectal Cancer Surgical Treatments
- Renal and Vascular Pathologies
- Healthcare cost, quality, practices
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
University of Pittsburgh Medical Center
2025
University of Pittsburgh
2025
Dana-Farber Brigham Cancer Center
2014-2024
Dana-Farber Cancer Institute
2014-2024
Massachusetts General Hospital
2017-2024
McGill University
2021-2024
Brigham and Women's Faulkner Hospital
2023
Evidence (Italy)
2023
We tested the hypothesis that prediction of renal cancer-specific survival can be improved if traditional predictor variables are used within a prognostic nomogram.Two cohorts patients treated with either radical or partial nephrectomy for cortical tumors were used: one (n = 2,530) nomogram development and internal validation (200 bootstrap resamples), second 1,422) external validation. Cox proportional hazards regression analyses modeled 2002 TNM stages, tumor size, Fuhrman grade,...
Abstract BACKGROUND There is few data on what constitutes the distribution of metastatic sites in prostate cancer (PCa). The aim our study was to systematically describe most common metastases a contemporary cohort PCa patients. METHODS Patients with were abstracted from Nationwide Inpatient Sample (1998–2010). Most within entire population described. Stratification performed according presence single or multiple (≥2 sites) metastases. Additionally, we evaluated amongst patients and without...
BACKGROUND To the authors' knowledge, it remains unknown whether race‐based differences in cancer outcomes have changed with time. In current study, authors assessed racial disparities cancer‐specific mortality improved over last 20 years. METHODS The Surveillance, Epidemiology, and End Results program was used to identify 2,713,474 patients diagnosed between 1988 2007 either lung, breast, prostate, or colorectal (the leading 3 causes of cancer‐related among each sex). After exclusions,...
We determined practice patterns and perioperative outcomes of open minimally invasive partial nephrectomy in the United States since introduction a robot-assisted modifier Nationwide Inpatient Sample.We identified all patients with nonmetastatic disease treated open, laparoscopic or robotic Sample between October 2008 December 2010. Utilization rates were assessed by year, patient hospital characteristics. evaluated vs using binary logistic regression models adjusted for covariates.In...
The role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) has become unclear since the introduction targeted therapies (TT). We sought to evaluate contemporary utilization rates CN and examine survival benefit compared with non-CN patients treated TT.We used National Cancer Data Base identify clinical mRCC TT between 2006 2013. intervention interest was CN. Multivariable logistic regression predicting receipt performed. Overall (OS) examined using Cox models...
Given the lack of randomized trials comparing robot-assisted radical prostatectomy (RARP) and open (ORP), we sought to re-examine outcomes these techniques using a cohort patients treated in postdissemination era.Overall, data from 5,915 with prostate cancer RARP or ORP within SEER-Medicare linked database diagnosed between October 2008 December 2009 were abstracted. Postoperative complications, blood transfusions, prolonged length stay (pLOS), readmission, additional therapies, costs care...
<h3>Importance</h3> Resource limitations because of pandemic or other stresses on infrastructure necessitate the triage time-sensitive care, including cancer treatments. Optimal time to treatment is underexplored, so recommendations for which treatments can be deferred are often based expert opinion. <h3>Objective</h3> To evaluate association between increased definitive therapy and mortality as a function type stage 4 most prevalent cancers in US. <h3>Design, Setting, Participants</h3> This...
Abstract We attempted to describe, in a series of clear cell renal carcinoma (RCC), the relationship between CAIX expression, VHL gene mutations, tumor characteristics and outcome. Radical nephrectomy was performed 100 patients. Genomic DNA extracted from frozen samples. Four amplimers covering whole coding sequence were synthesized by PCR sequenced. The monoclonal antibody M75 used evaluate protein expression immunohistochemically. mutations identified 58 patients (58%) high (>85%)...
<h3>Importance</h3> There is limited data on the prevalence and mortality of venous thromboembolism (VTE) following oncologic surgery. <h3>Objective</h3> To evaluate trends, factors, VTE major cancer <h3>Design, Setting, Participants</h3> Patients undergoing colectomy, cystectomy, esophagectomy, gastrectomy, hysterectomy, lung resection, pancreatectomy, or prostatectomy were identified retrospectively using Nationwide Inpatient Sample between January 1, 1999, December 30, 2009, resulting in...
Abstract BACKGROUND. C‐reactive protein (CRP) represents a promising prognostic variable in patients with sporadic renal cell carcinoma (RCC). It was hypothesized that CRP can improve the ability of standard RCC‐specific mortality (RCC‐SM) predictors treated nephrectomy for all stages RCC. METHODS. Radical performed 314 from 2 European centers. Life table, Kaplan‐Meier, and Cox regression analyses addressed RCC‐SM. Covariates included age, gender, TNM stage, tumor size, Fuhrman grade,...
What's known on the subject? and What does study add? Radical nephroureterectomy ( RNU ), standard of care treatment for high‐risk urothelial carcinoma upper tract UTUC results in loss a renal unit. Loss function decreases eligibility systemic chemotherapies decreased overall survival various malignancies. The shows that only small proportion patients had preoperative would allow cisplatin‐based chemotherapy. Moreover, eGFR significantly after , thereby lowering rate cisplatin to 16 52%...
Purpose Androgen deprivation therapy (ADT) may contribute to depression, yet several studies have not demonstrated a link. We aimed determine whether receipt of any ADT or longer duration for prostate cancer (PCa) is associated with an increased risk depression. Methods identified 78,552 men older than age 65 years stage I III PCa using the SEER-Medicare–linked database from 1992 2006, excluding patients psychiatric diagnoses within prior year. Our primary analysis was association between...