A5029615900- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Ureteral procedures and complications
- Pelvic floor disorders treatments
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Hormonal and reproductive studies
- Cardiac, Anesthesia and Surgical Outcomes
- Sexual function and dysfunction studies
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Renal and related cancers
- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Ultrasound Imaging and Elastography
Universitätsklinik Marien Hospital Herne
2016-2025
Ruhr University Bochum
2016-2025
Weatherford College
2024
Matrix Research (United States)
2019
Giorgio Cini Foundation
2018
Brigham and Women's Hospital
2013-2018
Harvard University
2013-2018
Eppendorf (Germany)
1997-2016
Université de Montréal
2013
Henry Ford Health System
2013
Olfactory receptors (ORs) are expressed not only in the sensory neurons of olfactory epithelium, where they detect volatile substances, but also various other tissues their potential functions largely unknown. Here, we report physiological characterization human OR51E2, named prostate-specific G-protein-coupled receptor (PSGR) due to its reported up-regulation prostate cancer. We identified androstenone derivatives as ligands for recombinant receptor. PSGR can be activated with odorant...
To examine postoperative complications in a contemporary series of patients after radical cystectomy using standardized reporting system, and to identify readily available preoperative risk factors.Using the modified Clavien-Dindo classification, we assessed 90-day clinical course 535 bladder cancer who underwent urinary diversion (ileal conduit n = 349, ileal neobladder 186) between June 2003 February 2012 at single institution. All Martin criteria for were met. Uni- multivariable analyses...
We evaluated whether real-time elastography guided biopsy improves prostate cancer detection compared to conventional systematic gray scale ultrasound guidance.A total of 353 consecutive patients suspicious for were prospectively randomized (178) or (175). Each patient enrolled in the study underwent a 10-core biopsy. Six lateral sectors (base, mid, apex) scanned areas, defined as stiffer blue lesions using and hypoechoic ultrasound. Suspicious areas sampled by single targeted considered...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Mar 2001A VALIDATED STRATEGY FOR SIDE SPECIFIC PREDICTION OF ORGAN CONFINED PROSTATE CANCER: A TOOL TO SELECT NERVE SPARING RADICAL PROSTATECTOMY MARKUS GRAEFEN, ALEXANDER HAESE, UWE PICHLMEIER, PETER G. HAMMERER, JOACHIM NOLDUS, KATHARINA BUTZ, ANDREAS ERBERSDOBLER, ROLF-PETER HENKE, MICHL, SALVATOR FERNANDEZ, and HARTWIG HULAND GRAEFENMARKUS GRAEFEN , HAESEALEXANDER HAESE PICHLMEIERUWE PICHLMEIER HAMMERERPETER HAMMERER...
Study Type – Prognosis (prospective cohort) Level of Evidence 2a What's known on the subject? and What does study add? Fournier's gangrene (FG) is a rare but life-threatening disease challenging treating medical staff. Despite fact that antibiotic therapy combined with surgery intensive care surveillance are performed as standard treatment, mortality rates remain high. There have been efforts to develop reliable tool predict severity disease, not only identify patients at highest risk major...
Decreased expression of the microRNA miR-205 has been observed in multiple tumour types due to its role epithelial mesenchymal transition, which promotes metastasis. We determined 111 archival samples prostate carcinoma and found it be strongly reduced most samples, with a median level 16% comparison benign tissue from same patient. Lower correlated significantly size levels decreased increasing Gleason score 7a=3+4 8=4+4. In addition, we describe anti-apoptotic protein BCL2 as target...
Priapism is a complex medical emergency that often requires prompt management. In this study, we examine the incidence of condition in United States population based setting, and assess patient department attributes associated with an increased likelihood hospitalization.Emergency visits primary diagnosis priapism between 2006 2009 were abstracted from Nationwide Emergency Department Sample. Univariable multivariable analyses performed hospital characteristics those admitted priapism.Between...
We prospectively assessed whether a combined approach of real-time elastography and contrast enhanced ultrasound would improve prostate cancer visualization.Between June 2011 January 2012, 100 patients with biopsy proven underwent preoperative transrectal multiparametric combining ultrasound. After initial elastographic screening for suspicious lesions, defined as blue areas decreased tissue strain, each lesion was allocated to the corresponding sector. The target largest area. Perfusion...
Background The use of adjuvant chemotherapy (AC) in pure urothelial carcinoma the bladder is established. Regarding variant histology, there a gap knowledge concerning optimal treatment after radical cystectomy (RC). objective this study was to assess effect AC on overall survival (OS) patients who had carcinoma, with concomitant or another histology. Methods Within National Cancer Data Base, 15,397 underwent RC for nonmetastatic, localized and positive lymph nodes (T2N+) locally advanced...
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does study add? Current studies evaluating real-time elastography in patients prior to radical prostatectomy reported sensitivities between 57% 100% for detection prostate cancer. This is first prospective comparing findings conventional gray-scale ultrasound with final pathology. A significant improvement cancer as well extra capsular shown by adding attributes tissue elasticity current...
No AccessJournal of UrologyAdult Urology1 Oct 2010The Impact Prostate Biopsy and Periprostatic Nerve Block on Erectile Voiding Function: A Prospective Study Tobias Klein, Rein Jueri Palisaar, Alexander Holz, Marko Brock, Joachim Noldus, Andreas Hinkel KleinTobias Klein , PalisaarRein Palisaar HolzAlexander Holz BrockMarko Brock NoldusJoachim Noldus HinkelAndreas View All Author Informationhttps://doi.org/10.1016/j.juro.2010.06.021AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Abstract Smoking is a major risk factor for the development of bladder cancer; however, functional consequences carcinogens in tobacco smoke and cancer–associated metabolic alterations remain poorly defined. We assessed profiles cancer smokers non-smokers identified key their metabolism. LC/MS bioinformatic analysis were performed to determine metabolome associated with further validated cell line models. Smokers found have elevated levels methylated metabolites, polycyclic aromatic...
Abstract Purpose This study aims to evaluate survival, health-related quality of life (HRQoL), psychosocial distress, and functional outcomes after radical cystectomy (RC) urinary diversion for ileal neobladder (INB) or conduit (IC) in a contemporary German cohort bladder cancer patients. Methods Patients undergoing inpatient rehabilitation RC between April 2018 December 2019 one high-volume center were surveyed regarding HRQoL, until two years RC. Results Eight-hundred forty-two patients...
We measured serum levels of human glandular kallikrein 2 (hK2) in patients treated with radical retropubic prostatectomy (rrP) for clinically localized prostate cancer (PCa) a total PSA (tPSA)-level below 10 ng/ml to investigate whether hK2 can be applied preoperatively distinguish organ-confined (pT2a/b) from nonorgan-confined (> or = pT3a)-PCa more accurately than PSA. Further, we evaluated hK2, free- and tPSA-concentrations all pathologic stages PCa.161 samples men scheduled rrP were...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 May 2000HUMAN GLANDULAR KALLIKREIN 2: A POTENTIAL SERUM MARKER FOR PREDICTING THE ORGAN CONFINED VERSUS NONORGAN GROWTH OF PROSTATE CANCER ALEXANDER HAESE, CHARLOTTE BECKER, JOACHIM NOLDUS, MARKUS GRAEFEN, EDITH HULAND, HARTWIG and HANS LILJA HAESEALEXANDER HAESE , BECKERCHARLOTTE BECKER NOLDUSJOACHIM NOLDUS GRAEFENMARKUS GRAEFEN HULANDEDITH HULAND HULANDHARTWIG LILJAHANS View All Author...