A5034539348- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Neuroendocrine regulation and behavior
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Stress Responses and Cortisol
- Renin-Angiotensin System Studies
- Ureteral procedures and complications
- Neuroscience of respiration and sleep
- Esophageal Cancer Research and Treatment
- Hormonal Regulation and Hypertension
- Molecular Biology Techniques and Applications
- Hormonal and reproductive studies
- Circadian rhythm and melatonin
- Urinary Tract Infections Management
- Electrolyte and hormonal disorders
- Apelin-related biomedical research
- DNA Repair Mechanisms
- MicroRNA in disease regulation
Postgraduate School of Molecular Medicine
2015-2024
Grochowski Hospital
2021-2024
St. Anna Hospital
2021
European Association of Urology
2014-2019
Centrum Medyczne Kształcenia Podyplomowego
2018
The Maria Sklodowska-Curie National Research Institute of Oncology
2017
Medical University of Warsaw
2002-2014
International Hereditary Cancer Center
2013
Pomeranian Medical University
2013
European Hospital
2013
To establish the contribution of eight founder alleles in three DNA damage repair genes (BRCA1, CHEK2 and NBS1) to prostate cancer Poland, measure impact these variants on survival among patients.Three thousand seven hundred fifty men with 3956 cancer-free controls were genotyped for BRCA1 (5382insC, 4153delA, C61G), four (1100delC, IVS2+1G>A, del5395, I157T), one allele NBS1 (657del5).The mutation was detected 53 3750 unselected cases compared 23 (0.6%) (odds ratio (OR)=2.5; P=0.0003). A...
We analysed critically the potential usefulness of RNA- and DNA-based biomarkers in supporting conventional histological diagnostic tests for prostate carcinoma (PCa) detection. Microarray profiling gene expression DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) 32 cancerous non-cancerous samples extracted by radical prostatectomy. The predictive value selected validated qPCR-based methods using tissue from 58 prostates and, separately, 227 core biopsies. HOXC6, AMACR...
To analyse the outcomes of adjuvant chemotherapy vs observation in a multicentre cohort patients with upper tract urothelial carcinoma (UTUC) order to clarify whether such benefit from after radical nephroureterectomy (RNU).Data 15 centres were collected for total 1544 patients, treated between 2000 and 2015. Criteria patient selection included pT2-4N0/x stage, or lymph node-positive disease, prior RNU. The standardized difference approach was used compare subgroup characteristics. Overall...
The present study was aimed at determining the role of centrally released oxytocin in regulation blood pressure and heart rate (HR) under resting conditions during an acute air-jet stress rats with a myocardial infarction controls infarcted. Four weeks after ligation coronary artery or sham surgery, conscious Sprague Dawley were subjected to one following intracerebroventricular (ICV) infusions: (1) 0.9% NaCl (control), (2) oxytocin, (3) receptor antagonist...
Abstract BACKGROUND The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer North America (about 20‐fold). geographical and ethnic extent this recurrent allele not yet determined. METHODS We assayed for presence 3,515 patients 2,604 controls from Poland estimated odds ratio allele. RESULTS was detected 3 (0.1%) individuals general population 20 (0.6%) men (Odds [OR] = 5.0; 95% CI: 1.5–16.7; P 0.008). present 4 416 (1.0%) familial (OR 8.4,...
Myocardial infarction (MI) significantly contributes to the global mortality rate, often leading heart failure (HF) due left ventricular remodeling. Key factors in pathomechanism of HF include nitrosative/oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. Furthermore, while a high-fat diet (HFD) is known exacerbate post-MI cardiac remodeling, its impact on these critical context not as well understood.
Background While histopathological evaluation remains the gold standard for diagnosis of prostate cancer (PCa), sampling errors remain a frequent problem; therefore, use tissue biomarkers that can distinguish between benign and malignant disease is potentially beneficial diagnostic strategy. Methods Deep sequencing miRNA transcriptome 14 prostatic hyperplasia (BPH) 60 cancerous non‐cancerous samples extracted from 34 cancer‐bearing prostates removed by prostatectomy was performed; latter...
Stress is one of the factors provoking cardiovascular complications. The purpose study was to explore role vasopressin (VP) in central control arterial blood pressure and heart rate under resting conditions during stimulation by an alarming stress (air jet stress) myocardial infarct-induced cardiac failure. Six groups male Sprague Dawley (SD) rats were subjected either sham surgery (sham rats) or ligation a left coronary artery (infarcted rats). After 5 weeks both infarcted...