A5062580185- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Genetic and Kidney Cyst Diseases
- Adrenal and Paraganglionic Tumors
- Bladder and Urothelial Cancer Treatments
- Pituitary Gland Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Hormonal Regulation and Hypertension
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Bone health and treatments
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Hernia repair and management
National Institutes of Health
2015-2025
National Cancer Institute
2015-2025
Sidney Kimmel Cancer Center
2025
Thomas Jefferson University Hospital
2025
Thomas Jefferson University
2024
Center for Cancer Research
2012-2024
Howard University Hospital
2018-2024
Howard University
2020-2023
Stanford University
2023
Memorial Sloan Kettering Cancer Center
2019
No AccessJournal of UrologyAdult Urology1 Dec 2012Succinate Dehydrogenase Kidney Cancer: An Aggressive Example the Warburg Effect in Cancer Christopher J. Ricketts, Brian Shuch, Cathy D. Vocke, Adam R. Metwalli, Gennady Bratslavsky, Lindsay Middelton, Youfeng Yang, Ming-Hui Wei, Stephen E. Pautler, James Peterson, Catherine A. Stolle, Berton Zbar, Maria Merino, Laura S. Schmidt, Peter Pinto, Ramaprasad Srinivasan, Karel Pacak, and W. Marston Linehan RickettsChristopher Ricketts Urologic...
Purpose Approximately 5% to 8% of renal cell carcinoma (RCC) is hereditary. No guidelines exist for patient selection RCC germline mutation testing. We evaluate how age onset could indicate the need testing detection inherited forms kidney cancer. Patients and Methods analyzed distribution cases in SEER-17 program our institutional hereditary cancer population. The distributions were compared by sex, race, histology, syndrome. Models established specific thresholds genetic Results median...
No AccessJournal of UrologyAdult Urology1 Dec 2008Robotic Partial Nephrectomy for Renal Hilar Tumors: A Multi-Institutional Analysis Craig G. Rogers, Adam Metwalli, M. Blatt, Gennady Bratslavsky, Mani Menon, W. Marston Linehan, and Peter A. Pinto RogersCraig Rogers Urologic Oncology Branch, National Cancer Institute, Institutes Health, Bethesda, Maryland Vattikuti Urology Henry Ford Hospital, Detroit, Michigan , MetwalliAdam Metwalli BlattAdam Blatt BratslavskyGennady Bratslavsky MenonMani...
Abstract Renal cell carcinoma (RCC) clusters in some families. Familial RCC arises from mutations several genes, including the von Hippel-Lindau (VHL) tumor suppressor, which is also mutated sporadic RCC. However, a significant percentage of familial remains unexplained. Recently, we discovered that BRCA1-associated protein-1 (BAP1) gene The BAP1 encodes nuclear deubiquitinase and appears to be classic two-hit suppressor gene. Somatic are associated with high-grade, clear-cell (ccRCC) poor...
No AccessJournal of UrologyAdult Urology1 Dec 2013Germline PTEN Mutation Cowden Syndrome: An Underappreciated Form Hereditary Kidney Cancer Brian Shuch, Christopher J. Ricketts, Cathy D. Vocke, Takefumi Komiya, Lindsay A. Middelton, Eric C. Kauffman, Maria Merino, Adam R. Metwalli, Phillip Dennis, and W. Marston Linehan ShuchBrian Shuch Urologic Oncology Branch, Center for Research, National Institute, Institutes Health, Bethesda, Maryland , RickettsChristopher Ricketts VockeCathy Vocke...
Type 2 3α-hydroxysteroid dehydrogenase (3α-HSD) is a multi-functional enzyme that possesses 3α-, 17β- and 20α-HSD, as well prostaglandin (PG) F synthase activities catalyzes androgen, estrogen, progestin PG metabolism. 3α-HSD was cloned from human prostate, member of the aldo-keto reductase (AKR) superfamily named AKR1C3. In androgen target tissues such AKR1C3 conversion Δ 4 -androstene-3,17-dione to testosterone, 5α-dihydrotestosterone 5α-androstane-3α,17β-diol (3α-diol), 3α-diol...
Published series of growth rates renal tumors on active surveillance largely consist without pathologic or genetic data. Growth kinetics genetically defined are not well known. Here, we evaluate the and their association with patient clinical characteristics.
OBJECTIVES To describe a technique for transurethral tumour inoculation, bioluminescence imaging (BLI) and validation of this approach using ex vivo magnetic resonance (MRI), as reproducible quantifiable model orthotopic bladder cancer is required to enable preclinical pharmacological studies intravesically administered anticancer agents the use BLI provides sensitive method monitor growth over time. MATERIALS AND METHODS Human KU‐7 cells were transduced with lentiviral construct stably...
Although renal cell carcinoma (RCC) is believed to have a strong hereditary component, there paucity of published guidelines for genetic risk assessment. A panel experts was convened gauge current opinions.
To assess the correlation in orthotopic bladder xenografts of bioluminescence imaging (BLI) with tumour volume as determined by magnetic resonance (MRI), and to define potential role hypoxia necrosis relationship between BLI at autopsy.Orthotopic tumours were established nude mice KU7 253J B-V cells expressing luciferase. MRI performed weekly. Tumour was calculated from MR images each time point. Autopsy 4 weeks after inoculation 45 min injection piminidazole. haematoxylin eosin staining...
Multifocal and hereditary kidney cancers often require repeated ipsilateral nephron sparing procedures with higher blood loss complication rates compared to first time renal surgery. Consequently, many surgeons avoid minimally invasive techniques in the setting. We present characteristics, complications, short-term functional outcomes of patients who underwent a repeat robotic partial nephrectomy (rRPNx).A database was retrospectively reviewed identify nephrectomies between January 2007...
Results from prior studies show contradictory evidence in determining whether utilization of renal ischemia during partial nephrectomies (PN) results worse functional outcomes. Data assessing a large cohort patients with no PN are lacking. The purpose this study was to evaluate the use and type affects A retrospective review 742 undergoing were assessed split into 4 cohorts: (n = 455), cold 63), warm time (WIT) < 30 minutes 164), WIT ≥ 60). Twelve-month relative glomerular filtration rate...
Purpose: Inhibitors of apoptosis proteins (IAPs) have been shown to contribute resistance neoplastic cells chemotherapy and biologic antineoplastic agents. Consequently, new agents are being developed targeting this family proteins. In a panel bladder cancer cell lines, we evaluated Smac mimetic that antagonizes several IAPs for its suitability therapy.
To elucidate the oncologic behavior of Micropapillary Urothelial Bladder Carcinoma (MPBC), a rare aggressive variant histology.All MPBC patients in SEER 17 database were compared with those traditional urothelial carcinoma (UC). Kaplan-Meier curves used to determine OS and CSS. A Cox proportional hazards model (CPH) was constructed test effect covariates on outcomes.From 2001-2008, 120 identified, 0.1% all bladder cancer. presented more high grade (86.1% vs. 38.7%, p<0.0001) stage disease...