A5101644293- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Global Cancer Incidence and Screening
- Radiopharmaceutical Chemistry and Applications
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Sexual Differentiation and Disorders
- Urologic and reproductive health conditions
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Galectins and Cancer Biology
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Uniformed Services University of the Health Sciences
2015-2024
Henry M. Jackson Foundation
2011-2024
Eli Lilly (United States)
2021-2024
Nantong University
2015-2024
Fujian Medical University
2022-2023
Walter Reed National Military Medical Center
2012-2022
Beijing University of Chemical Technology
2022
Biomarkers that are validated in independent cohorts needed to improve risk assessment for prostate cancer (PCa).A racially diverse cohort of men (20% African American [AA]) was used evaluate the association clinically 17-gene Genomic Prostate Score (GPS) with recurrence after radical prostatectomy and adverse pathology (AP) at surgery.Biopsies from 431 treated National Comprehensive Cancer Network (NCCN) very low-, or intermediate-risk PCa between 1990 2011 two US military medical centers...
No AccessJournal of UrologyAdult Urology1 Nov 2008PCA3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volumeis accompanied byThe Significance Monoamine Oxidase-A Expression in High Grade Prostate Cancer Eric J. Whitman, Jack Groskopf, Amina Ali, Yongmei Chen, Amy Blase, Bungo Furusato, Gyorgy Petrovics, Mona Ibrahim, Sally Elsamanoudi, Jennifer Cullen, Isabell A. Sesterhenn, Stephen Brassell, Harry Rittenhouse, Shiv Srivastava, David G. McLeod WhitmanEric...
Abstract Polymorphisms at 8q24 are robustly associated with prostate cancer risk. The risk variants located in nonprotein coding regions and their mechanism has not been fully elucidated. To further dissect the function of this locus, we tested two hypotheses: (a) unannotated microRNAs (miRNA) transcribed region, (b) region is a cis-acting enhancer. Using next generation sequencing, were interrogated for known novel miRNAs histologically normal radical prostatectomy tissue. We also evaluated...
The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence ERG overexpression cancer cells due to TMPRSS2-ERG fusions suggest for causal roles protein neoplastic process. fusion junctions have been extensively studied cancer. However, virtually nothing known about nature full-length transcripts and encoded proteins. This study focuses on qualitative quantitative features cancer.Full-length were cloned sequenced from a cDNA library...
Currently there is a lack of consensus on screening recommendations for prostate cancer with minimal guidance the cessation in older men. We defined clinicopathological features and outcomes men 70 years old or who were diagnosed cancer.The Center Prostate Disease Research database was queried all from 1989 to 2009. The patients stratified into age quartiles by race. Cox proportional hazard models used compare across patient stratifications. Kaplan-Meier analysis biochemical recurrence-free,...
Evaluation of cancer genomes in global context is great interest light changing ethnic distribution the world population. We focused our study on men African ancestry because their disproportionately higher rate prostate (CaP) incidence and mortality. present a systematic whole genome analyses, revealing alterations that differentiate American (AA) Caucasian (CA) CaP genomes. discovered recurrent deletion chromosome 3q13.31 centering LSAMP locus was prevalent tumors from AA (cumulative...
Predicting the clinical course of prostate cancer is challenging due to wide biological spectrum disease. The objective our study was identify prognostic markers in patients 'sera using a multi-omics discovery platform.Pre-surgical serum samples collected from longitudinal, racially diverse, patient cohort (N = 382) were examined. Linear Regression and Bayesian computational approaches integrated with multi-omics, used select predict biochemical recurrence (BCR). BCR-free survival modeled...
Abstract MUC16 is a well-validated cell surface marker for serous adenocarcinomas of the ovary and other gynecologic malignancies that distinguished by highly repetitive sequences (“mucin repeats”) in extracellular domain (ECD). We produced compared two monoclonal antibodies: one (11D10) recognizing unique, nonrepeating epitope ECD another (3A5) recognizes repeats binds multiple sites on each protein. 3A5 conjugated to cytotoxic drugs exhibited superior toxicity against tumor cells vitro...
A role for the Notch signalling pathway in formation of arteriovenous malformations during development has been suggested. However, whether is involved brain humans remains unclear. Here, we performed immunohistochemistry on surgically resected and found that, compared with control vascular tissue, Notch-1 was activated smooth muscle endothelial cells lesional tissue. Western blotting showed an form malformations, irrespective clinical presentation or without preoperative embolization, but...
Study Type – Prognosis (retrospective cohort) Level of Evidence 2b What’s known on the subject? and What does study add? Patients who develop biochemical (PSA) recurrence after prostatectomy may subsequently metastases leading to their eventual death. However, many such patients receive additional therapies before developing metastases, so natural history disease progression in these is poorly described. We aimed report metastasis‐free survival overall for using a multicentre database....
Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency BRCA1 (BRCA1/2) gene alterations was recently reported metastatic castration-resistant PCa specimens. Mutations vary racial ethnic groups including African-American (AA) Caucasian-American (CA) populations. genes were sequenced (Ion AmpliSeq targeted sequencing) archived blood DNA specimens 1240 patients, 30% AA three different cohorts: localized early stage (T2) (N = 935); advanced...
Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared control brain tissues (n=5), BAVM tissue (n=139) had a higher expression (by ELISA) myeloperoxidase (MPO) (193±189 vs. 6±3, ng/mg, P<.001), (28±32 0.7±0.6, and IL-6 (102±218 0.1±0.1, pg/mg, but not eNOS (114±87 65±9, P=.09). highly correlated with (R2=.76, as well (R2=.32, P<.001). In...
Brain arteriovenous malformations cause intracranial hemorrhage. Molecular characterization of lesional tissue implicates angiogenic (vascular endothelial growth factor, ANG-2, matrix metalloproteinase-9) and inflammatory (cytokines chemokines) pathways, but the pathogenesis remain obscure medical therapy is lacking. Macrophage neutrophil invasion has also been observed in absence prior Common polymorphisms interleukin-1beta activin receptor-like kinase-1 are associated with malformation...
Prevalent gene fusions in prostate cancer involve androgen-regulated promoters (primarily TMPRSS2) and ETS transcription factors (predominantly ETS-regulated (ERG)], which result tumor selective overexpression of ERG two thirds patients. Because diverse genomic fusion events lead to cancer, we reasoned that it may be more practical capture such alterations using an assay targeting sequences retained fusions. This study evaluates the potential quantitating mRNA post-digital rectal exam (DRE)...
Introduction:In this review, the International Agency for Research on Cancer's cancer epidemiology databases were used to examine prostate (PCa) age-standardized incidence rates (ASIR) in selected Asian nations, including Cancer Incidence Five Continents (CI5) and GLOBOCAN databases, an effort determine whether ASIRs are rising regions of world with historically low risk PCa development.Materials Methods: nations adequate data quality considered review.PCa ASIR estimates from CI5 2008 public...
Open AccessJournal of UrologyAdult Urology1 Feb 2021A Urine Exosome Gene Expression Panel Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy Indu Kohaar, Yongmei Chen, Sreedatta Banerjee, Talaibek Borbiev, Huai-Ching Kuo, Amina Ali, Lakshmi Ravindranath, Jacob Kagan, Sudhir Srivastava, Albert Dobi, Isabell A. Sesterhenn, Inger L. Rosner, Jennifer Cullen, Shiv Gyorgy Petrovics KohaarIndu Kohaar *Correspondence: E-mail Address: [email protected] Center for Disease...
This study describes the treatment patterns and outcomes of patients with CLL/SLL in a de-identified real-world oncology electronic health records database.Adult were eligible if they had received cBTKi therapy, both BCL2i, or all 4 drug classes (cBTKi, rituximab, chemotherapy) at any time during first 5 lines therapy. Time-to-event evaluated using Kaplan Meier method. No statistical comparisons conducted; analyses descriptive conducted SAS Enterprise.A total 9578 eligible: 52.0% (n = 4983)...
AbstractBackground: Cancer cells gain selection advantages by the coordinated silencing of protective and activation cell proliferation/cell survival genes. Evaluations epithelial transcriptome benign malignant prostate glands laser capture microdissection (LCM) identified Lactotransferrin (LTF) as most significantly downregulated gene in cancer (CaP) (P