A5000998172- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Infant Nutrition and Health
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Lung Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Radiomics and Machine Learning in Medical Imaging
- Infant Health and Development
- Gene Regulatory Network Analysis
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Physiological and biochemical adaptations
- Thermoregulation and physiological responses
- Breastfeeding Practices and Influences
- Biochemical effects in animals
- Biomarkers in Disease Mechanisms
Northwestern University
2018-2024
The University of Texas Southwestern Medical Center
2015-2022
University of Arizona
2011-2021
The University of Texas at Dallas
2018
Southwestern Medical Center
2016
North Carolina State University
1997
White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of stromal cells has remained unresolved. We combined single-cell RNA-sequencing FACS to identify isolate functionally distinct subpopulations PDGFRβ+ within visceral WAT adult mice. LY6C- CD9- represent highly adipogenic adipocyte precursor ('APCs'), whereas LY6C+ fibro-inflammatory progenitors ('FIPs'). FIPs lack...
Dermal adipose tissue (also known as dermal white and herein referred to dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate mature adipocytes origin rapidly reappearing at different stages remain unclear. Here, we isolated characterized fat cellular molecular level. Together with dWAT's dynamic responses external stimuli, established that are a distinct class high plasticity. By combining pulse-chase lineage tracing single-cell...
Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting active period mitigates metabolic syndrome through mechanisms that remain unknown. We found genetic enhancement adipocyte thermogenesis ablation zinc finger protein 423 (ZFP423) attenuated obesity caused by consumption a high-fat diet during inactive (light) increasing futile creatine cycling in mice. Circadian control metabolism underlies timing...
Pathologic expansion of white adipose tissue (WAT) in obesity is characterized by adipocyte hypertrophy, inflammation, and fibrosis; however, factors triggering this maladaptive remodeling are largely unknown. Here, we test the hypothesis that potential to recruit new adipocytes from Pdgfrβ+ preadipocytes determines visceral WAT health obesity. We manipulate levels Pparg, master regulator adipogenesis, precursors adult mice. Increasing adipogenic capacity through Pparg overexpression results...
The increased incidence of obesity and associated metabolic diseases has driven research focused on genetically or pharmacologically alleviating dysfunction. These studies employ a range fasting-refeeding models including 4-24 h fasts, "overnight" meal feeding. Still, we lack literature that describes the physiologically relevant adaptations accompany changes in duration fasting re-feeding. Since liver is central to whole body homeostasis, investigated timing fast-induced shift toward...
In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD
Inflammatory bowel disease (IBD) is a spectrum of autoimmune diseases affecting the gastrointestinal tract characterized by relapsing and remitting course gut mucosal inflammation. Disease flares can be difficult to predict, current practice IBD activity surveillance through endoscopy invasive requires medical expertise. Recent advancements in synthetic biology raise possibility that symbiotic microbes engineered selectively detect biomarkers used clinical practice. Here, we introduce an...
Zfp423 is a multi zinc-finger transcription factor expressed in preadipocytes and mature adipocytes vivo. Our recent work has revealed critical role for maintaining the fate of white adult mice through suppression beige cell thermogenic gene program; loss results white-to-beige phenotypic switch. However, exact requirements fetal stages early adipose development vivo have not been clarified. Here, we utilize two models that confer adipose-specific inactivation during (Adiponectin-Cre;...
Ghrelin is an orexigenic gastric peptide hormone secreted when caloric intake limited. also regulates blood glucose, as emphasized by the hypoglycemia that induced restriction in mouse models of deficient ghrelin signaling. Here, we hypothesized activation β1-adrenergic receptors (β1ARs) localized to cells required for restriction-associated release and ensuing protective glucoregulatory response. In mice lacking β1AR specifically ghrelin-expressing cells, secretion was markedly blunted,...
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective. Unlike WAT, visceral WAT is resistant to adopting a protective thermogenic phenotype characterized by the accumulation Ucp1 + beige/BRITE adipocytes (termed ‘browning’). In this study, we investigated physiological consequences browning murine selective genetic ablation Zfp423 , transcriptional suppressor...
Rising temperatures resulting from climate change will increase the incidence of heat stress, negatively impacting labor force and food animal production. Heat stress elevates circulating β-OH butyrate, which induces vasodilation through GPR109a. Interestingly, both intraperitoneal butyrate administration induce hypophagia. Thus, we aimed to investigate role in hypophagia mice. We found that niacin, a mimetic cannot be oxidized generate ATP, also reduces intake. depression intake as result...