A5084736369- Diabetes Management and Research
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Obesity and Health Practices
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Mobile Health and mHealth Applications
- Child and Adolescent Health
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Circular RNAs in diseases
- Bariatric Surgery and Outcomes
- Signaling Pathways in Disease
- Dietary Effects on Health
- Thermoregulation and physiological responses
- Diabetes Management and Education
- Occupational and environmental lung diseases
- Eating Disorders and Behaviors
- Physical Activity and Health
The University of Texas Southwestern Medical Center
2014-2024
Southwestern Medical Center
2015-2024
Duke University
2023-2024
Duke Medical Center
2024
Children's Medical Center
2021
University of Massachusetts Chan Medical School
2014-2016
New York College of Health Professions
2014
Obesity promotes insulin resistance associated with liver inflammation, elevated glucose production, and type 2 diabetes. Although is attenuated in genetic mouse models that suppress systemic it not clear whether local resident macrophages liver, denoted Kupffer cells (KCs), directly contribute to this syndrome. We addressed question by selectively silencing the expression of master regulator NF-κB, KCs obese mice. used glucan-encapsulated small interfering RNA particles (GeRPs) silence gene...
Purpose The purpose of this exploratory focus group study was to describe the perspectives teens and their parents about self-management knowledge, behaviors (including division labor associated with T1D management), resources used manage T1D. overall goal is use information develop a teen–family transition clinic. Methods self family management framework undergirded separate teen–parent groups that were conducted concurrently. Note-based qualitative content analysis used, resulting in...
Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism. Hypoxia-inducible Gene 2 (Hig2) is recently identified LD-associated protein hepatocytes promotes hepatic storage, but the adipocyte had not been investigated. Here we tested hypothesis Hig2 localization to LDs adipocytes adipose deposition and systemic glucose homeostasis.White brown adipocyte-deficient (Hig2fl/fl × Adiponection cre+) selective brown/beige...
Purpose The purpose of this study was to develop and pilot-test an innovative behavioral intervention in adolescents with type 1 diabetes mellitus (T1DM) incorporating structured care a pet improve glycemic control. Methods Twenty-eight A1C > 8.5% (69 mmol/mol) were randomly assigned either the group (care Betta splendens fish) or control (usual care). Adolescents given instructions associate daily weekly fish duties self-management tasks, including blood glucose testing parent-adolescent...
Abstract: Depression is more common in youth with type 1 diabetes (T1D) compared to without diabetes. This study aims assess the efficacy of Competent Adulthood Transition Cognitive Humanistic and Interpersonal Teaching (CATCH-IT), an internet-based cognitive behavioral therapy (CBT) intervention, adolescents T1D depressive symptoms. Adolescents (13 17 years old) mild (score 5–9) or moderate 10–14) symptoms on Patient Health Questionnaire-Adolescent (PHQ-A) screening assessment were...
Background Managing type 1 diabetes mellitus (T1DM) in preschool-aged children has unique challenges that can negatively impact glycemic control and parental coping. Objective To evaluate the of a camp-based multi-component intervention on glycated hemoglobin A1c (HbA1c) young with T1DM psychosocial measures for their parents. Subjects methods Two separate cohorts 18 (ages 3-5 years) families participated included didactic interactive parent education, child-centered education family-based...
Type 1 diabetes mellitus (T1DM) a chronic characterized by an absolute insulin deficiency requires conscientious patient self-management to maintain glucose control within normal range. Family cohesion and adaptability, positive coping strategies, social support adequate self-regulatory behavior are found favorably influence glycemic control. Our hypothesis was that the responsible care of companion animal is associated with these attributes correlated successful management illness such as...
Abstract Background Omentin-1, also known as Intelectin-1 (ITLN1), is an adipokine with plasma levels associated diabetes, obesity, and coronary artery disease. Recent studies suggest that ITLN1 can mitigate myocardial ischemic injury but the expression of in heart itself has not been well characterized. The purpose this study to discern relationship between pattern RNA human level circulating protein from same patients following ischemia. Methods A large cohort (n = 140) undergoing elective...
Summary There is little documentation of the distribution specific health conditions across obesity classes (I, II, III), especially for paediatric populations who are seen routine care in large United States US healthcare systems. The aim this study was to assess odds presenting ≥2 obesity‐related comorbidities as well overall these co‐morbidities children by class I/II/III status controlling key sociodemographic characteristics. This retrospective (2015–2019) electronic record review...
Children referred to pediatric obesity programs are at high risk of binge-eating disorder (BED) symptoms. Our goal was develop and evaluate the Children's Brief Binge-Eating Questionnaire (CBBEQ) as a rapid screen BED symptomatology. Seventy patients between ages 7 18 years (57% females) completed CBBEQ underwent Eating Disorder Assessment for DSM-5 (EDA). Reliability validity were assessed by examining results compared with EDA, well measures sleep, depression, anxiety. Twenty-four seventy...
Little is known about whether body composition changes differently between children with and without obesity following 1 year of nonintervention. Therefore, we investigated in early pubescent (8-12 yr) before after a period Early yr; Tanner stage ≤ 3) (body mass index, BMI ≥ 95th percentile) (15th < 85th were recruited. At baseline, 88 (
Body fat distribution is a predictor of metabolic health in obesity. In this Classics Diabetes article, we revisit 1985 article by Swedish investigators Ohlson et al. This work was one the first prospective population-based studies that established relationship between abdominal adiposity and risk for developing diabetes. Here, discuss evolving concepts regarding link regional diabetes other chronic disorders. Moreover, highlight fundamental questions remain unresolved.
The nutritional status is a major determinant of health and well being. In India, most the research works on nutrition diet surveys indicate that populations are undernourished subsisting inadequate diet. diets deficient in terms either calorie or vitamins minerals. Three hundred sixty six women were selected for present study. Out which 123 Inter University players, 129 college players rest 114 students. All had given their written consent voluntary participation this Diet survey was...
Metabolic and bariatric surgery (MBS) can be a well tolerated effective treatment option for severe obesity in adolescents. We compared outcomes adolescents that did not proceed to surgery.A single-center longitudinal study (2015-2020). Patients were identified as LSG if they completed laparoscopic sleeve gastrectomy within 6 months of initial visit NoLSG not. Chi-square, Fisher exact, nonparametric Kruskal-Wallis tests, Linear Mixed Models (LMM) used compare over 2 years.Three hundred...
Children attending diabetes camp are more active, increasing the risk of hypoglycemia. Decreasing initial insulin doses may reduce this risk. The objectives our study were to compare glycemic control between campers receiving multiple daily injections (MDI) and continuous subcutaneous infusion (CSII), analyze impact decreasing basal by 10%.We analyzed 849 sessions (599 children, 5-19 years old) from Camp Sweeney's 2016/2017 summers. Campers separated into groups year route (MDI_2016,...