A5002776726- Vitamin D Research Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diabetes Management and Research
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Veterinary Equine Medical Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Digestive system and related health
- Diet and metabolism studies
- Injury Epidemiology and Prevention
- Celiac Disease Research and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cervical Cancer and HPV Research
- Muscle Physiology and Disorders
- Traffic and Road Safety
- Ethics in Clinical Research
- Diverticular Disease and Complications
- Emergency and Acute Care Studies
- Lymphoma Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Diabetes Treatment and Management
- Tendon Structure and Treatment
- Lymphadenopathy Diagnosis and Analysis
- Helminth infection and control
University of Massachusetts Chan Medical School
2012-2021
UMass Memorial Medical Center
2011-2018
Memorial Medical Center
2018
Presbyterian Hospital
2016
Cornell University
2016
The University of Texas Southwestern Medical Center
2015
UMass Memorial Health Care
2014
Laerdal (Norway)
2013
University of Massachusetts Amherst
2012
Berkshire Hathaway (United States)
2011
The objective of this study was to determine whether the use heated, humidified, high-flow nasal cannula (HFNC) therapy is associated with a decreased need for intubation in patients presenting pediatric emergency department (PED) and admitted intensive care unit (PICU) acute respiratory insufficiency (ARI).A retrospective all from PED PICU ARI January 2006 through December 2009. Patients before availability HFNC (cohort 1) were compared those after but implementation an institution-wide...
The Ebola virus disease (EVD) epidemic, which began in West Africa December 2013, claimed more than 11,000 lives, with 4,800 of these deaths occurring Liberia. epidemic had an additional effect paralyzing the health-care systems affected countries, led to even greater mortality and morbidity. Little is known about impact that on provision basic health care. During period from March May 2015, we undertook a nationwide, community-based survey learn access during EVD A cluster sampling strategy...
Context There is no consensus on the vitamin D status of children and adolescents with inflammatory bowel disease (IBD). Aim To determine patients IBD by comparing their serum 25(OH)D concentration to that healthy controls. Hypothesis Serum will be lower in compared Subjects Methods A case-controlled retrospective study subjects (n = 58) 2–20 years (male n 31, age 16.38±2.21 years; female 27, age16.56±2.08 years) controls 116; male 49, 13.90±4.59 67, 15.04±4.12years). Study subject inclusion...
Summary This retrospective study describes the computed tomography ( CT ) findings in 59 horses presented with diseases of head over 8 years that underwent examination this region, including dental or sinonasal Group A (n = 42), osseous and/or articular B 11) and soft tissue C 6). For , radiographic comparison was possible. Computed had higher sensitivity (100%) specificity (96.7%) than radiography diagnosing disease. Compared to identification sinus involvement less sensitive, particularly...
RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and negatives. To ameliorate issues, we combined information from the existing HDF together with new performed multiple orthologous reagents (MORR). In addition being traditionally validated, MORR historical were quantitatively integrated by adaptation an established analysis program, RIGER, for collective interpretation each...
Background The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children adolescents with either type 1 (T1D) or 2 diabetes (T2D). Hypothesis Vitamin will improve control. Aim To determine the effect alanine transaminase (ALT), hemoglobin A1c (HbA1c), serum 25-hydroxyvitamin [25(OH)D] concentration. Subjects Methods A retrospective study 131 subjects T1D (n = 88∶46 females, 42 males), T2D 43∶26 17 males) ages 3–18 years between 2007–2013....
Background Participants in clinical trials frequently fail to appreciate key differences between research and care. This phenomenon, known as therapeutic misconception, undermines informed consent research, but date there have been no effective interventions reduce it concerns expressed that do so might impede recruitment. We determined whether a scientific reframing intervention reduces misconception without significantly reducing willingness participate hypothetical trials. Methods...
>50% of patients with new-onset type 1 diabetes (T1D) do not enter partial clinical remission (PCR); early identification these may improve initial glycemic control and reduce long-term complications.To determine whether routinely obtainable parameters predict non-remission in children adolescents T1D.Data on were collected for the first 36 months disease 204 subjects ages 2-14 years diabetes. There 86 remitters (age 9.1±3.0y; male 57%), 118 non-remitters 7.0±3.1y; 40.7%). PCR was defined as...
Discovering how to improve survival and establishing clinical reference points for children diagnosed with endemic Burkitt lymphoma (eBL) in resource‐constrained settings has recaptured international attention. Using multivariate analyses, we evaluated 428 eBL Kenya age, gender, tumor stage, nutritional status, hemoglobin, lactate dehydrogenase (LDH), Epstein‐Barr virus (EBV) Plasmodium falciparum prior induction of chemotherapy (cyclophosphamide, vincristine, methotrexate doxorubicin)...
Context Insulin resistance has been proposed as one of the causes poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, role adjunctive metformin, an insulin sensitizer, on these patients is unclear. Objective To compare effect metformin vs. placebo hemoglobin A1c (HbA1c), total daily dose (TDD) insulin, and other parameters T1D. Hypothesis Adjunctive therapy will improve Design, Setting, Participants A 9-mo randomized, double-blind, controlled trial 28...
Current practice for diagnosing neonatal abstinence syndrome and guiding pharmacological management of drug withdrawal is dependent on nursing assessments repeated evaluation clinical signs.This single-center quality improvement initiative was designed to improve accuracy consistency Finnegan scores among nurses.One-hundred seventy nurses participated in a single-session withdrawal-assessment program that incorporated education, scoring guidelines, restructured scale. Nurses scored...
Importance Irritable bowel syndrome (IBS) is associated with significant morbidity in children and adolescents, the therapeutic efficacy of available treatment options limited. The role vitamin D supplementation pediatric IBS unclear as status patients unknown. Equally, relationship psychosomatic symptoms adolescents unclear. Aim To characterize using a case-control study design. Hypothesis Serum 25-hydroxyvitamin [25(OH)D] concentration will be similar between controls. Subjects methods A...
Abstract Objective —To analyze factors associated with interdog household aggression and determine treatment outcomes. Design —Retrospective case series survey. Animals —38 pairs of dogs aggression. Each pair was considered 1 case. Procedures —Records that were examined during initial or follow-up consultations at a veterinary teaching hospital from December 5, 2006, to 2007, analyzed for clinical features. Data regarding outcome, owner compliance, efficacy recommended treatments obtained by...
Objective: To determine the relationship between 25-hydroxyvitamin D [25(OH)D] levels and asthma symptom severity in children adolescents.
Introduction There is no comprehensive, systematic analysis of the vitamin D status prisoners in scientific literature. Objective To investigate and its determinants US prison inmates. Hypothesis Given uniformity dietary intake amongst inmates, will be determined by non-dietary factors such as skin pigmentation, security level-, duration incarceration. Subjects Methods A retrospective study 526 inmates (males, n = 502, age 48.6±12.5 years; females, 24, 44.1±12.2) Massachusetts prisons....
Facioscapulohumeral muscular dystrophy (FSHD) is characterized by incomplete penetrance and intra-familial clinical variability. The disease has been associated with the genetic epigenetic features of D4Z4 repetitive elements at 4q35. Recently, hypomethylation proposed as a reliable marker in FSHD diagnosis. We exploited Italian Registry for FSHD, which families are classified using Clinical Comprehensive Evaluation Form (CCEF). A total 122 index cases showing classical phenotype (CCEF,...
Background: Celiac disease (CD) is an autoimmune enteropathy characterized by villus atrophy and malabsorption of essential nutrients. Vitamin D deficiency has been described in diseases, but its status prepubertal children with CD not adequately studied.
Abstract Background: It is unclear whether the gold standard test for detection of partial clinical remission (PCR) in new-onset type 1 diabetes (T1D), insulin-dose adjusted Hemoglobin A Methods: retrospective analysis 204 subjects ages 2–14 years, mean age 7.9±3.2 (male 7.8±3.4 [n=98]; female 7.9±3.0 [n=106], p=0.816) with T1D. Anthropometric and biochemical data were collected first 36 months disease. PCR was defined by both IDAA Results: There 86 (42.2%) (age 9.1±3.0 years; male 57%)...
The data on the association of sleep duration and blood pressure in pediatric age group have been mixed most studies focused weekday duration. purpose this study was to compare weekend patterns between children adolescents with newly diagnosed primary hypertension a normotensive control group.Children from nephrology clinic, aged 6-18 years were compared an sex matched general clinic. questions about bed time getting out times Pediatric Sleep Questionnaire (PSQ) used obtain time, Daytime...