A5065634167- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- Family Support in Illness
- Interprofessional Education and Collaboration
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Economic and Financial Impacts of Cancer
- Viral-associated cancers and disorders
- Neurofibromatosis and Schwannoma Cases
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Renal and related cancers
- Adolescent and Pediatric Healthcare
- Diabetes Management and Research
- Neuroblastoma Research and Treatments
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Virus-based gene therapy research
- Pharmaceutical studies and practices
- Neutropenia and Cancer Infections
- Advances in Oncology and Radiotherapy
Indiana University School of Medicine
2014-2025
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University
2005-2024
Richard M. Fairbanks Foundation
2024
University School
2020-2024
Princess Máxima Center
2024
AMPATH
2024
Moi University
2017-2023
Riley Hospital for Children
2010-2022
Indiana University Health
2011-2020
To determine whether adult survivors (>or= 18 years of age) childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity and to assess patient treatment variables that influence risk.A retrospective cohort participants the Childhood Cancer Survivor Study was used compare 1,765 ALL 2,565 siblings cancer survivors. Body-mass index (BMI; kilograms per square meter), calculated from self-reported heights weights, prevalence being overweight (BMI, 25-29.9) or obese (BMI >or=...
Binding of interleukin 2 (IL-2) to its receptor generates intracellular signals, including the activation tyrosine and serine/threonine kinases. In this study serine/threonine-specific ribosomal protein S6 kinases in response IL-2 was analyzed murine T-cell line CTLL-20, a model system IL-2-dependent proliferation. Two major classes have been characterized: 90-kDa (rsk) family 70-kDa family. addition recombinant IL-2, total kinase activity increased. This could not be immunoprecipitated by...
Neurofibromin, the protein encoded by NF1 tumor-suppressor gene, negatively regulates output of p21ras (Ras) proteins accelerating hydrolysis active Ras-guanosine triphosphate to inactive diphosphate. Children with neurofibromatosis type 1 (NF1) are predisposed juvenile chronic myelogenous leukemia (JCML) and other malignant myeloid disorders, heterozygous Nf1 knockout mice spontaneously develop a disorder that resembles JCML. Both human murine leukemias show loss normal allele. JCML cells...
A prospective trial was conducted to confirm the diagnostic performance of (123)I-mIBG scintigraphy in patients with known or suspected neuroblastoma.One hundred (mean age 4.7 years) were enrolled, 86 a previous diagnosis neuroblastoma, 13 disease based upon symptoms, imaging findings, and elevated catecholamines, one adult an abdominal tumor thought be neuroendocrine origin. All underwent whole-body planar 24 hr following IV administration 1-10 mCi (37-370 MBq) (123)I-mIBG. SPECT...
Purpose To determine dose-limiting toxicities, maximum-tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of weekly intravenous temsirolimus, a mammalian target rapamycin (mTOR) signaling pathway inhibitor, in pediatric patients with recurrent or refractory solid tumors. Patients Methods Cohorts three to six 1 21 years age tumors were treated 1-hour infusion temsirolimus for 3 weeks per course at one four levels: 10, 25, 75, 150 mg/m 2 . During the first two courses,...
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by proliferation of the granulocytic cell line. The incidence CML in Kenya estimated at near 2000 cases annually. associated with poor prognosis without treatment. Tyrosine kinase inhibitors are approved for treatment adults and children confirmed disease. Diagnostic testing public setting limited not covered Kenyan National Health Insurance Fund. To establish clinical fluorescence situ hybridization assay...
The WHO Global Initiative for Childhood Cancer will likely increase the number of childhood cancer survivors in resource-poor countries. This study explored survivorship care Kenya through parental reports on late effects and follow-up needs survivors. Parents Kenyan (under 18 years old) who completed treatment at least one year were interviewed using semi-structured questionnaires from 2021 to 2022. 54 interviewed. Survivors had solid tumors (52%) hematological (48%). Most received...
To evaluate the response rate, survival, and toxicity of mitoxantrone cytarabine induction, high-dose etoposide intensification, further consolidation/maintenance therapies, including bone marrow transplantation, in children with relapsed, refractory, or secondary acute myeloid leukemia (AML). to 2-chlorodeoxyadenosine (2-CDA) (VP-16) patients who did not respond cytarabine.Patients relapsed/refractory AML (n = 101) 13) were entered.Mitoxantrone induction achieved a remission rate 76% for...
Acute Lymphoblastic Leukemia, commonly known as ALL, is a predominant form of cancer during childhood. With the advent modern healthcare support, 5-year survival rate has been impressive in recent past. However, long-term ALL survivors embattle several treatment-related medical and socio-economic complications due to excessive inordinate chemotherapy doses received treatment. In this work, we present model-based approach personalize 6-Mercaptopurine (6-MP) treatment for childhood with...
Early diagnosis and start of treatment are fundamental goals in cancer care. This study determines the time lag factors that influence to treatment. Study participants were parents childhood patients diagnosed between August 2013 July 2014 a hospital Kenya. Patient, physician, diagnosis, treatment, health care system, total delay explored using questionnaire. Demographic medical data collected from patients' records. Parents 99 interviewed (response rate: 80%). Median was 102 (9-1021) days....
Discovering how to improve survival and establishing clinical reference points for children diagnosed with endemic Burkitt lymphoma (eBL) in resource‐constrained settings has recaptured international attention. Using multivariate analyses, we evaluated 428 eBL Kenya age, gender, tumor stage, nutritional status, hemoglobin, lactate dehydrogenase (LDH), Epstein‐Barr virus (EBV) Plasmodium falciparum prior induction of chemotherapy (cyclophosphamide, vincristine, methotrexate doxorubicin)...
Vincristine (VCR) is a critical part of treatment in pediatric malignancies and associated with dose-dependent peripheral neuropathy (vincristine-induced [VIPN]). Our previous findings show VCR metabolism regulated by the CYP3A5 gene. Individuals who are low expressers metabolize slower experience more severe VIPN as compared to high expressers. Preliminary observations suggest that Caucasians nonCaucasians.Kenyan children cancer were undergoing including recruited for prospective cohort...
To describe the patterns and predictors of hospital resource utilization in a cohort children with newly diagnosed cancer, retrospective study 195 consecutively cancer at single large Midwestern children's was conducted. Patients were between November 1995 March 1997. All encounters for these patients starting from time diagnosis to 3 years identified using administrative data. The categorized into four diagnostic groups: lymphoid malignancies (acute lymphoblastic leukemia lymphoma), myeloid...
Wilms tumor is the commonest renal malignancy in childhood. Survival high-income countries approximately 90%, whereas low-income countries, it less than 50%. This study assessed treatment outcomes of patients with at a Kenyan academic hospital.We conducted retrospective medical record review all children diagnosed between 2010 and 2012. Data on various sociodemographic clinical characteristics were collected.Of 39 tumor, 41% had event-free survival, 31% abandoned treatment, 23% died, 5%...