A5020367012- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Cancer-related gene regulation
- Blood disorders and treatments
- Hemostasis and retained surgical items
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Myeloid Leukemia Treatments
- Cerebral Venous Sinus Thrombosis
- Neutropenia and Cancer Infections
- Systemic Lupus Erythematosus Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Blood properties and coagulation
- Immunodeficiency and Autoimmune Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
- Vascular anomalies and interventions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac tumors and thrombi
- Dialysis and Renal Disease Management
Istituto Giannina Gaslini
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2024
Children's Hospital
1999-2024
University of Oxford
2017
Churchill Hospital
2017
Thrombosis Research Institute
2008-2014
Children's Research Hospital
1986-2013
University of Campania "Luigi Vanvitelli"
2013
Hôpital Necker-Enfants Malades
2013
University of Naples Federico II
2013
For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated development clinically relevant inhibitory antibodies (inhibitor development).
Summary The aim of this study was to develop a simplified ultrasound scanning procedure and scoring method, named Haemophilia Early Arthropathy Detection with UltraSound [HEAD-US], evaluate joints patients haemophilic arthropathy. After an initial consensus-based process involving multidisciplinary panel experts, three comprehensive evidence-based US procedures image the elbow, knee ankle were established increase sensitivity in detection early signs joint involvement while keeping technique...
Summary Rigorous evidence is lacking on long-term outcomes of factor VIII (FVIII) prophylaxis initiated in adolescent or adult patients with severe haemophilia A. The prospective, open-label Prophylaxis versus On-demand Therapy Through Economic Report (POTTER) study (Clinical-Trials.gov NCT01159587) compared late secondary (recombinant FVIII-FS 20–30 IU/kg thrice weekly) on-demand treatment aged 12 to 55 years annual number joint bleeding episodes (primary endpoint), total episodes,...
Abstract Recent evidence demonstrated that weekly prophylaxis with subcutaneous bispecific antibody (emicizumab) has shown higher efficacy in adolescent and adults patients affected by haemophilia A (HA) inhibitor, compared treated on demand or bypassing agents (BPAs). However, no economic evaluations assessing the value sustainability of emicizumab have been performed Europe. This study assessed cost-effectiveness BPA its possible budget impact from Italian National Health Service (NHS)...
Summary The discussion of prophylactic therapy in haemophilia is largely focused on joint outcomes. impact intracranial haemorrhage ( ICH ) less known. This study aimed to analyse children with haemophilia, a focus different prophylaxis regimens and sequelae . We conducted multicentre retrospective prospective that included 33 centres from 20 countries. Inclusion criteria were adolescents born between 1993 2014, severe A or B without inhibitors. Participants categorized by regimen: full,...
In a group of newly diagnosed acute lymphocytic leukemia (ALL) children we evaluated number hemostatic and inflammatory markers at diagnosis different time points during chemotherapy for the remission induction to identify alterations in plasma levels prothrombotic before course chemotherapy. The following were evaluated: thrombin-antithrombin complex (TAT), D-Dimer, plasminogen activator inhibitor 1 (PAI-1), antithrombin, fibrinogen, von Willebrand factor (VWF) antigen high molecular weight...
Acquired haemophilia A (AHA) is a rare bleeding disorder due to autoantibodies coagulation factor VIII that may be secondary autoimmune diseases, cancer, drugs, pregnancy, infections, or idiopathic. Recurrent bleeding, often severe, mostly in muscles and soft tissues, isolated prolonged activated partial thromboplastin time (aPTT), the absence of personal family history are typical features should raise suspicion AHA. Poor awareness disease results diagnostic delays inappropriate...
Migraine can induce ischaemic stroke, and is considered an independent risk factor for stroke in the young. To date, nature of link between migraine essentially unknown. Forty-five children were studied. Homocysteine levels (fasting post methionine load), vitamin B12 plasma folate levels, V Leiden, II G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T A1298C mutations examined. Compared with controls, patients had higher post-methionine load homocysteine values (19.5 ± 4.9 vs. 16.9...
Venous thromboembolism (VTE) is a relatively rare condition in childhood with treatment mainly based on extrapolation from studies adults. Therefore, clinical trials of anticoagulation children require novel approaches to deal numerous challenges. The EINSTEIN-Jr program identified pediatric rivaroxaban regimens commencing vitro dose finding followed by evaluation different ages through phase I and II using extensive modeling determine bodyweight-related doses. Use this approach resulted...
Background: Intracranial hemorrhage (ICH) is a highly serious event in patients with haemophilia (PWH) which leads to disability and some cases death. ICH occurs among all ages but particularly frequent newborns. Aim: The primary aim was assess the incidence mortality due an Italian population of PWH. Secondary aims were evaluate risk factors for ICH, role prophylaxis, clinical management presenting ICH. Methods: A retrospective-prospective registry established network Association...
Antiphospholipid antibodies (APA) are often associated with severe clinical manifestations, especially in the setting of systemic lupus erythematosus (SLE). Here we have investigated prevalence anticardiolipin (aCL) and anticoagulant (LA) paediatric patients affected SLE, JCA overlap syndromes (OS) correlated presence aCL LA features. were assayed by enzyme-limited immunoassay; was determined activated partial thromboplastin time kaolin clotting test. assays performed parallel on at least...