Chris Van Geet
A5059991336- Platelet Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Genomics and Rare Diseases
- Blood groups and transfusion
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Genetic Syndromes and Imprinting
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood disorders and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuropeptides and Animal Physiology
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Iron Metabolism and Disorders
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Genetics and Neurodevelopmental Disorders
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Blood properties and coagulation
- Glycosylation and Glycoproteins Research
- Metabolism and Genetic Disorders
- Autism Spectrum Disorder Research
- Protein Kinase Regulation and GTPase Signaling
- Diabetes Treatment and Management
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2006-2025
University of Cambridge
2009-2019
Cambridge University Hospitals NHS Foundation Trust
2016-2019
NHS Blood and Transplant
2016-2018
National Institute for Health Research
2017
VIB-KU Leuven Center for Cancer Biology
2006-2017
Institute of Cancer Research
2016
Center for Vascular Biology Research
2002-2015
Bernhard Nocht Institute for Tropical Medicine
2012
For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated development clinically relevant inhibitory antibodies (inhibitor development).
A BLUEPRINT of immune cell development To determine the epigenetic mechanisms that direct blood cells to develop into many components our system, consortium examined regulation DNA and RNA transcription dissect molecular traits govern differentiation. By inducing responses, Saeed et al. document changes in genome underlie Cheng demonstrate trained monocytes are highly dependent on breakdown sugars presence oxygen, which allows produce energy needed mount an response. Chen examine transcripts...
Heteroplasmy incidence in mitochondrial DNA In humans, (mtDNA) is predominantly maternally inherited. mtDNA under selection to prevent heteroplasmy—the transmission of multiple genetic variants into the next generation. Wei et al. explored human sequences determine genome structure, selection, and transmission. Whole-genome sequencing revealed that about 45% individuals carry heteroplasmic at levels greater than 1% their total mtDNA. Furthermore, studies more 1500 mother-offspring pairs...
Objectives Antibiotic resistance (ABR) particularly hits resource poor countries, and is fuelled by irrational antibiotic (AB) prescribing. We surveyed knowledge, attitudes practices of AB prescribing among medical students doctors in Kisangani, DR Congo. Methods Self-administered questionnaires. Results A total 184 questionnaires were completed (response rate 94.4%). Knowledge about was low (mean score 4.9/8 points), as the estimation local rates S. Typhi Klebsiella spp.(correct 42.5% 6.9%...
MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in the gene for nonmuscle myosin heavy chain IIA (NMMHC-IIA). MYH9-RD characterized considerable variability clinical evolution: patients present at birth with only thrombocytopenia, but some of them subsequently develop sensorineural deafness, cataract, and/or nephropathy often leading to end-stage renal (ESRD). We searched genotype-phenotype correlations largest series consecutive collected so far (255...
E527K hyperactive SRC results in megakaryocytes with increased podosome formation, thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.
Wastewater surveillance plays an important role in the management of coronavirus disease 2019 (COVID-19) pandemic all over world. Using different wastewater collection points Leuven, we wanted to investigate use as early warning system for uprise infections and a tool follow circulation specific variants concern (VOCs) particular geographic areas. samples were collected from local neighborhood sewers large regional treatment plant (WWTP) area Belgium. After virus concentration, severe acute...
Autism is a neurodevelopmental disorder characterized by impaired social reciprocity, communication and stereotypical behaviors. Despite strong evidence for genetic basis, few susceptibility genes have been identified. Here, we describe the positional cloning of SCAMP5, CLIC4 PPCDC as candidate autism, starting from person with idiopathic, sporadic autism carrying de novo chromosomal translocation. One these genes, SCAMP5 silenced on derivative chromosome, encodes brain-enriched protein...
Background Although severe malaria is an important cause of mortality among children in Burkina Faso, data on community-acquired invasive bacterial infections (IBI, bacteremia and meningitis) are lacking, as well the involved pathogens their antibiotic resistance rates. Methods The present study was conducted a rural hospital health center seasonal transmission area. Hospitalized (<15 years) presenting with T≥38.0°C and/or signs illness were enrolled upon admission. Malaria diagnosis blood...
Background. This study reports the microbiological landscape of Salmonella Typhi and invasive nontyphoidal (iNTS) in Democratic Republic Congo (DRC). Methods. Blood cultures obtained from hospital-admitted patients suspected bloodstream infection (BSI) 4 11 provinces DRC (Kinshasa, Bas-Congo, Equateur, Orientale) were processed. Sampling had started 2007; results for period 2011–2014 are reported. Results. iNTS cultured 194 (1.4%) 840 (5.9%), respectively, 14 110 BSI episodes ranked first...
Telomere length is a risk factor in disease and the dynamics of telomere are crucial to our understanding cell replication vitality. The proliferation whole genome sequencing represents an unprecedented opportunity glean new insights into biology on previously unimaginable scale. To this end, number approaches for estimating from whole-genome data have been proposed. Here we present Telomerecat, novel approach estimation length. Previous methods dependent telomeres being known, which may be...
Recombinant human erythropoietin was administered for up to 40 weeks nine patients on chronic haemodialysis. From the third week of administration onwards, not only haemoglobin and haematocrit but also platelet count rose, latter, however, transiently. Subnormal aggregation before therapy improved transiently in parallel with dosage. The bleeding time normalized almost all patients. There were no major side-effects. We conclude that recombinant improves haemostasis haemodialysis by...
Olmsted syndrome is a rare congenital skin disorder presenting with periorifical hyperkeratotic lesions and mutilating palmoplantar keratoderma, which often associated infections of the keratotic area. A recent study identified de novo mutations causing constitutive activation TRPV3 as cause manifestations syndrome.Genetic, clinical immunological profiling was performed on case patient diagnosis syndrome.The found to harbour previously undescribed 1718G-C transversion in TRPV3, G573A point...
Pseudohypoparathyroidism (PHP) is caused by (epi)genetic defects in the imprinted GNAS cluster. Current classification of PHP patients hampered clinical and molecular diagnostic overlaps. The European Consortium for study designed a genome-wide methylation to improve diagnosis. HumanMethylation 450K BeadChip was used analyze 24 with parathyroid hormone resistance 20 age- gender-matched controls. Patients were previously diagnosed GNAS-specific differentially methylated regions (DMRs) include...
Group A rotavirus (RVA) infections form a major public health problem, especially in low-income countries like the Democratic Republic of Congo (COD). However, limited data on RVA diversity is available from sub-Saharan Africa general and COD particular. Therefore, first aim this study was to determine genetic 99 RVAs detected during 2007–2010 Kisangani, COD. The predominant G-type G1 (39%) most P-type P[6] (53%). total eight different G/P-combinations were found: G1P[8] (28%), G8P[6] (26%),...