Catherine Williamson
A5052297121- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Liver Diseases and Immunity
- Reproductive System and Pregnancy
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
- Gestational Diabetes Research and Management
- Cholesterol and Lipid Metabolism
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Hepatitis B Virus Studies
- Adipose Tissue and Metabolism
- Trace Elements in Health
- Growth Hormone and Insulin-like Growth Factors
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Genetic Syndromes and Imprinting
- Fatty Acid Research and Health
- Parathyroid Disorders and Treatments
- Hypothalamic control of reproductive hormones
King's College London
2016-2025
Imperial College London
2012-2025
Hammersmith Hospital
2006-2024
Guy's and St Thomas' NHS Foundation Trust
2011-2024
The Tavistock and Portman NHS Foundation Trust
2024
Society of Thoracic Surgeons
2022
University College London
2014-2022
Lithuanian University of Health Sciences
2019-2021
St Thomas' Hospital
2003-2021
Bendigo Health
2021
In the triennium 2006-2008, 261 women in UK died directly or indirectly related to pregnancy.The overall maternal mortality rate was 11.39 per 100,000 maternities.Direct deaths decreased from 6.24 maternities 2003-2005 4.67 2006-2008 (p = 0.02).This decline is predominantly due reduction thromboembolism and, a lesser extent, haemorrhage.For first time there has been inequalities gap, with significant decrease rates among those living most deprived areas and lowest socio-economic...
The calcium-sensing receptor regulates the secretion of parathyroid hormone in response to changes extracellular calcium concentrations, and mutations that result a loss function are associated with familial hypocalciuric hypercalcemia. Mutations involving gain have been hypocalcemia two kindreds. We examined possibility latter type mutation may phenotype hypercalciuria.
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, characterized by maternal pruritus and raised serum bile acids. Our objectives were to describe the epidemiology complications associated with severe ICP test hypothesis that adverse perinatal outcomes are increased in these women. A prospective population-based case-control study national coverage was undertaken using UK Obstetric Surveillance System (UKOSS). Control data for comparison obtained from women...
Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with rates stillbirth, preterm birth, neonatal unit admission. Ursodeoxycholic widely used as a treatment without an adequate evidence base. We aimed to evaluate whether ursodeoxycholic reduces adverse perinatal outcomes in women intrahepatic pregnancy.We did double-blind, multicentre, randomised placebo-controlled trial at 33 hospital maternity units England...
Heteroplasmy incidence in mitochondrial DNA In humans, (mtDNA) is predominantly maternally inherited. mtDNA under selection to prevent heteroplasmy—the transmission of multiple genetic variants into the next generation. Wei et al. explored human sequences determine genome structure, selection, and transmission. Whole-genome sequencing revealed that about 45% individuals carry heteroplasmic at levels greater than 1% their total mtDNA. Furthermore, studies more 1500 mother-offspring pairs...
Intrahepatic cholestasis of pregnancy (ICP) is a liver disease with serious consequences for the mother and fetus. Two pedigrees have been reported ICP in mothers children subtype autosomal recessive progressive familial intrahepatic (PFIC) raised serum γ‐glutamyl transpeptidase (γ-GT). Affected homozygous mutations MDR3 gene (also called ABCB4), heterozygous ICP. More frequently, however, occurs women no known family history PFIC genetic basis this disorder unknown. We investigated eight...
Objective To explore the clinical features of obstetric cholestasis pregnancies in UK white Caucasians. Design A questionnaire survey. Setting Study coordinated at Queen Charlotte's Hospital. Population Clinical 352 affected 227 Caucasian women identified via a patient support group. Methods Evaluation gestation which prematurity and intrauterine death occur, recording additional complicated by cholestasis. Main outcome measures The timing prematurity. Results Among pregnancies, 23 (7%) were...
<h3>Background:</h3> Intrahepatic cholestasis of pregnancy (ICP) has a complex aetiology with significant genetic component. <i>ABCB11</i> encodes the bile salt export pump (BSEP); mutations cause spectrum cholestatic disease, and are implicated in ICP. <h3>Methods:</h3> variation ICP was investigated by screening for five mutant alleles (E297G, D482G, N591S, D676Y G855R) V444A polymorphism (c.1331T>C, rs2287622) two cohorts (n = 333 UK, n 158 continental Europe), controls 261) V444A. PCR...
<b>Objectives</b> To evaluate current processes by which young children presenting with a febrile illness but suspected of having serious bacterial infection are diagnosed and treated, to develop test multivariable model distinguish infections from self limiting non-bacterial illnesses. <b>Design </b>Two year prospective cohort study. <b>Setting </b>The emergency department The Children's Hospital at Westmead, Australia. <b>Participants</b> Children aged less than 5 years between 1 July 2004...
Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy-specific liver disease and associated with an increased risk adverse fetal outcomes, including preterm labor intrauterine death. The endocrine signals that cause are not known but 3α-sulfated progesterone metabolites have been shown to be elevated in ICP, leading us study impact sulfated on farnesoid X receptor (FXR)-mediated bile acid homeostasis pathways. Here we report 3β-sulfated metabolite epiallopregnanolone...
A national UK workshop to discuss practical clinical management issues related pregnancy in women with myasthenia gravis was held May 2011. The purpose develop recommendations guide general neurologists and obstetricians facilitate best practice before, during after pregnancy. main conclusions were (1) planning should be instituted well advance of any potential allow time for myasthenic status drug optimisation; (2) multidisciplinary liaison through the involvement relevant specialists occur...
Background Intrahepatic cholestasis of pregnancy (ICP) is a common disease affecting up to 5% pregnancies and which can cause fetal arrhythmia sudden intrauterine death. We previously demonstrated that bile acid taurocholate (TC), raised in the bloodstream ICP, acutely alter rate rhythm contraction induce abnormal calcium destabilization cultured neonatal rat cardiomyocytes (NRCM). Apart from their hepatic functions acids are ubiquitous signalling molecules with diverse systemic effects...
Background: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging genetic basis. Heterozygous mutations in the gene encoding bone morphogenetic protein receptor type 2 ( BMPR2 ) are commonest cause of PAH, whereas biallelic eukaryotic translation initiation factor alpha kinase 4 EIF2AK4 described pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Here, we determine frequency these and define genotype-phenotype characteristics large cohort patients...