Tamam Bakchoul
A5066897101- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Intramuscular injections and effects
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Blood properties and coagulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Blood transfusion and management
- Long-Term Effects of COVID-19
- Blood donation and transfusion practices
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Hemophilia Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 detection and testing
- Proteoglycans and glycosaminoglycans research
- Renal Diseases and Glomerulopathies
- Adipokines, Inflammation, and Metabolic Diseases
University of Tübingen
2016-2025
Bernstein Center for Computational Neuroscience Tübingen
2016-2025
University Children's Hospital Tübingen
2013-2025
Institute for Transfusion Medicine
2011-2024
Universitätsklinikum Tübingen
2016-2024
Universitätsmedizin Greifswald
2013-2019
Universität Greifswald
2012-2018
University of Giessen
2007-2016
Universitas Gadjah Mada
2016
Versiti Blood Center of Wisconsin
2008-2016
SARS-CoV-2 is evolving with mutations in the receptor binding domain (RBD) being of particular concern. It important to know how much cross-protection offered between strains following vaccination or infection. Here, we obtain serum and saliva samples from groups vaccinated (Pfizer BNT-162b2), infected uninfected individuals characterize antibody response RBD mutant strains. Vaccinated have a robust humoral after second dose high IgG titers saliva. Antibody responses however show...
The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. To prevent severe infection, mass vaccination campaigns with several vaccine types are currently underway. We report pathological immunological findings 8 patients who developed vaccine-induced immune thrombotic thrombocytopenia (VITT) after administration of SARS-CoV-2 ChAdOx1 nCoV-19. analyzed patient material using enzyme assays, flow cytometry heparin-induced platelet aggregation assay performed...
It is commonly accepted that antibody-mediated removal of platelets represents a major mechanism platelet destruction in immune thrombocytopenic purpura (ITP). Although complement activation may participate clearance, frequency and specificity have not yet been studied systematically ITP.We examined blood samples from 240 patients with ITP. Samples were assessed for the presence free bound autoantibodies by standard glycoprotein-specific assay (monoclonal antibody-specific immobilization...
Background: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging genetic basis. Heterozygous mutations in the gene encoding bone morphogenetic protein receptor type 2 ( BMPR2 ) are commonest cause of PAH, whereas biallelic eukaryotic translation initiation factor alpha kinase 4 EIF2AK4 described pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Here, we determine frequency these and define genotype-phenotype characteristics large cohort patients...
Abstract The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis required understand the manifestation progression of COVID-19, monitor seroconversion within general population, support vaccine development. majority currently available commercial serological assays only quantify antibody against individual antigens, limiting our understanding response. To overcome this, we have developed multiplex immunoassay (MultiCoV-Ab) including spike nucleocapsid...
Objective— Fetal/neonatal alloimmune thrombocytopenia is a severe bleeding disorder, which can result in intracranial hemorrhage (ICH), leading to death or neurological sequelae. In whites, maternal anti–human platelet antigen-1a (HPA-1a) antibodies are responsible for the majority of cases. No predictive factors ICH available guide prophylactic treatment during pregnancy. this study, we investigated from mothers with ICH-positive fetal/neonatal and ICH-negative identify serological...
Significance CLL is characterized by autonomous B cell receptor (BCR) signaling. subsets are empirically defined sequence similarities of the BCR heavy chain. However, in unfavorable subset 2, an acquired mutation (termed R110) light chain stimulates This study demonstrates that oncogenic R110 dictates prognosis and not restricted to conventional 2. Interestingly, carriers a particular light-chain allele ( IGLV3-21 * 01 ) predisposed develop because this enables signaling as single-point...
Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), congenital disorder characterized by uterovaginal aplasia, but functional ovaries. Based on our four successful living-donor transplantations and two resulting births, this analysis presents parameters relevant standardizing recipient/donor selection, UTx surgery, postoperative treatment, their implementation in routine settings. We descriptively analyzed...
Myocardial ischemia is one of the leading health problems worldwide. Therapy consists restitution coronary perfusion which followed by myocardial inflammation. Platelet-neutrophil interaction a crucial process during inflammation, yet its consequences are not fully understood. Here, we show that platelet-neutrophil complexes (PNCs) increased in patients with acute infarction and this associated levels neuronal guidance protein semaphorin 7A (SEMA7A). To investigate further, injected WT...
The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation.The outcome 4233 consecutive transplants performed between 2012 and 2015 in 18 German transplant centers was evaluated. Most used a stepwise pretransplant antibody screening with bead array tests differentiation positive samples single antigen assays. Using these results, DSA against HLA-A, -B, -C, -DRB1 -DQB1 were determined....
Anemia is a common complication of chronic kidney disease, affecting the quality life patients. Among various factors, such as iron and erythropoietin deficiency, reduced red blood cell (RBC) lifespan has been implicated in pathogenesis anemia. However, mechanistic data on vivo RBC dysfunction disease are lacking. Herein, we describe development disease-associated anemia mice with proteinuric resulting from either administration doxorubicin or an inducible podocin deficiency. In both...