A5008511400- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Insect Pest Control Strategies
- Forensic Entomology and Diptera Studies
- Monoclonal and Polyclonal Antibodies Research
- Insect behavior and control techniques
- Insect Utilization and Effects
- Meat and Animal Product Quality
- Long-Term Effects of COVID-19
- Parasites and Host Interactions
- Climate Change and Health Impacts
- Effects of Environmental Stressors on Livestock
- Agricultural and Food Production Studies
- Wound Healing and Treatments
- Pharmacological Effects and Assays
- Invertebrate Immune Response Mechanisms
- Receptor Mechanisms and Signaling
- Insect Resistance and Genetics
- Immunotherapy and Immune Responses
University Children's Hospital Tübingen
2021-2024
University of Tübingen
2020-2022
German Center for Infection Research
2021
Universitätsklinikum Tübingen
2021
Centre de Recherche Médicales de Lambaréné
2020
Universidade do Estado do Amazonas
2017-2018
Fundação de Medicina Tropical
2016-2018
Escola Superior de Ciências da Saúde
2017-2018
Universidad Nacional de Colombia
2014-2015
Universidad del Rosario
2013-2014
SARS-CoV-2 is evolving with mutations in the receptor binding domain (RBD) being of particular concern. It important to know how much cross-protection offered between strains following vaccination or infection. Here, we obtain serum and saliva samples from groups vaccinated (Pfizer BNT-162b2), infected uninfected individuals characterize antibody response RBD mutant strains. Vaccinated have a robust humoral after second dose high IgG titers saliva. Antibody responses however show...
The mosquito resistance to the insecticides threatens malaria control efforts, potentially becoming a major public health issue. Alternative methods like ivermectin (IVM) administration humans has been suggested as possible vector reduce Plasmodium transmission. Anopheles aquasalis and darlingi are competent vectors for vivax, they have responsible various outbreaks in coast of Brazil Amazon Region South America.To determine IVM susceptibility against P. vivax An. darlingi, were mixed...
SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present mucosa, more precisely saliva, after a recovered infection and also following vaccination. We report here antibody persistence plasma up to 15 months mild COVID-19. The IgG response was measured every two 72 participants using an established validated in-house ELISA assay. In addition, virus inhibitory activity assessed surrogate neutralization test before SARS-CoV-2-specific concentrations...
Malaria is transmitted when an infected mosquito delivers Plasmodium sporozoites into a vertebrate host. There are many species of and, in general, the infection host-specific. For example, gallinaceum avian parasite, while berghei infects mice. These two parasites have been extensively used as experimental models malaria transmission. falciparum and vivax most important agents human malaria, life-threatening disease global importance. To complete their life cycle, must traverse midgut form...
Malaria remains a major public health concern. Vector control measures based solely on insecticide treated nets (ITNs) and indoor residual spraying (IRS) have demonstrated not to be feasible for malaria elimination. It has been shown that ivermectin affects several aspects of Anopheles species biology. Along the Latin American seacoast, aquasalis Curry plays an important role in transmission. The observation mosquitoes locomotor activity under laboratory conditions can reveal details their...
<ns4:p><ns4:bold>Background:</ns4:bold>Reducing the burden of malaria requires better understanding vector populations, particularly in forested regions where incidence remains elevated. Here, we characterized vectors a locality near Yaoundé international airport, Cameroon, including species composition, abundance,<ns4:italic>Plasmodium</ns4:italic>infection rate, insecticide resistance profiles and underlying mechanisms.</ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold>Blood-fed adult mosquitoes...
The rapid emergence of the Omicron variant and its large number mutations led to classification as a concern (VOC) by World Health Organization. Subsequently, evolved into distinct sublineages (eg, BA.1 BA.2), which currently represent majority global infections. Initial studies neutralizing response toward in convalescent vaccinated individuals showed substantial reduction.We assessed antibody (immunoglobulin G [IgG]) binding, ACE2 (angiotensin-converting enzyme 2) binding inhibition, IgG...
Reducing the burden of malaria requires better understanding vector populations, particularly in forested regions where incidence remains elevated. Here, we characterized vectors a locality near Yaoundé international airport, Cameroon, including species composition, abundance,
Saliva is a body fluid with hitherto unused potential for the assessment of SARS-CoV-2 antibodies. Specific antibodies can indicate past infection and allow to estimate proportion individuals protective immunity. First, we carefully characterized plasma samples obtained from adult control groups without prior using certified reference ELISAs. Simultaneously collected saliva confirmed convalescent negative where then used validate herein newly developed ELISA detection IgG in saliva. The was...
La capacidad de retención agua (CRA) es uno los parámetros calidad la carne más importante, dado que posee asociación con percepción jugosidad y pérdida peso pieza cárnica durante procedimientos como maduración, cocción otro tipo procesamiento tecnológico. CRA en crudo cocinado (CRAr CRAc respectivamente) fue evaluada 164 machos castrados cruzados, cuales se realizó genotipificación 23 regiones genómicas genes CAPN1, CAST, DES, PRKAG3 RYR1. El marcador CAST2959 presentó el parámetro CRAr...
Abstract The rapid emergence of the Omicron variant and its large number mutations has led to classification as a concern (VOC) by WHO(1). Initial studies on neutralizing response towards this within convalescent vaccinated individuals have identified substantial reductions(2-8). However many these sample sets used in were either small, uniform nature, or compared only wild-type (WT) or, at most, few other VOC. Here, we assessed IgG binding, (Angiotensin-Converting Enzyme 2) ACE2 binding...
Abstract The SARS-CoV-2 pandemic virus is consistently evolving with mutations within the receptor binding domain (RBD) 1 being of particular concern 2-4 . To date, there little research into protection offered following vaccination or infection against RBD mutants in emerging variants (UK 3 , South African 5 Mink 6 and Southern California 7 ). investigate this, serum saliva samples were obtained from groups vaccinated (Pfizer BNT-162b2 8 ), infected uninfected individuals. Antibody...
This cross-sectional study evaluates IgG antibody levels in children and adolescents Germany following SARS-CoV-2 infection.
Cooking losses.Creole breeds.Juiciness.Meat quality.Weight losses. RESUMENLa capacidad de retención agua en crudo (CRAr) y cocinado (CRAc) fue determinada carne madurada a 7, 14 21 días post mórtem.Los músculos Longissimus dorsi (LD) Semitendinosus (ST) 164 machos castrados provenientes del cruce las razas Simmental, Normanda, Blanco Orejinegro, Braunvieh, Guzerat, Brahman Blanco, Rojo, Limousin Romosinuano con hembras blanco.Para el parámetro CRAr LD se presentó significancia los factores...
Methylene blue (MB) is the oldest synthetic anti-infective. Its high potency against asexual and sexual stages of malaria parasites well documented. This study aimed to investigate possible additional activities MB in interfering with parasite transmission determine target Anopheles vectors humans. MB’s transmission-blocking activity was first evaluated by an ex vivo direct membrane feeding assay (DMFA) using Plasmodium falciparum field isolates. To anti-mosquito stage activity,...
The World Health Organization recommends three drug anti-malarial combinations: cloroquine+primaquine, artesiminin+primaquine, and cloroquine+tafenoquine. These combinations aim to eradicate Plasmodium by disrupting its life cycle within the human body. We evaluated effect of these medications on vectorial competence two main vectors in New World.
Abstract Our current knowledge of the clinical burden, biology, and transmission Plasmodium malariae is extremely scarce. To start addressing some those questions, we experimentally infected Anopheles gambiae mosquitoes with fresh P. isolates obtained from asymptomatic individuals in Lambaréné, Gabon. The proportion via direct membrane feeding assay either monoinfections (16% [19 121]) or coinfections (28% [31 112]) was higher after serum replacement than parallel groups without (4% [4 102]...
The world has been confronted with the COVID-19 pandemic for more than one year. Severe disease is often found among elderly people, whereas most young children and adolescents show mild symptoms or even remain asymptomatic, so that infection might be undiagnosed. Therefore, only limited epidemiological data on SARS-CoV-2 in adults are available.
<sec> <title>BACKGROUND</title> The world has been confronted with the COVID-19 pandemic for more than one year. Severe disease is often found among elderly people, whereas most young children and adolescents show mild symptoms or even remain asymptomatic, so that infection might be undiagnosed. Therefore, only limited epidemiological data on SARS-CoV-2 in adults are available. </sec> <title>OBJECTIVE</title> This study aims to determine prevalence of antibodies from city Tübingen, Germany,...