Peter G. Kremsner
A5043369631- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Global Maternal and Child Health
- Immune Cell Function and Interaction
- Trypanosoma species research and implications
- Parasite Biology and Host Interactions
- Research on Leishmaniasis Studies
- Computational Drug Discovery Methods
- Hemoglobinopathies and Related Disorders
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Vector-borne infectious diseases
- Antimicrobial Resistance in Staphylococcus
University of Tübingen
2016-2025
German Center for Infection Research
2016-2025
Centre de Recherche Médicales de Lambaréné
2016-2025
Universitätsklinikum Tübingen
2015-2024
University Children's Hospital Tübingen
2011-2024
German Institute for Disaster Medicine
2007-2023
Bernstein Center for Computational Neuroscience Tübingen
2023
Naval Medical Research Command
2023
Institut Africain d'Informatique
2021-2022
Vietnamese - German Center of Excellence in Medical Research
2016-2021
An ongoing phase 3 study of the efficacy, safety, and immunogenicity candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries.From March 2009 through January 2011, we enrolled 15,460 children two age categories--6 to 12 weeks 5 17 months age--for vaccination with either or a non-malaria comparator vaccine. The primary end point analysis was efficacy against clinical during after first 6000 at enrollment who received all three doses according protocol. After 250 had...
The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe in children 5 to 17 months age by approximately 50% an ongoing phase 3 trial. We studied infants 6 12 weeks recruited for the same
Recent gains in reducing the global burden of malaria are threatened by emergence Plasmodium falciparum resistance to artemisinins. The discovery that mutations portions a P. gene encoding kelch (K13)–propeller domains major determinant has provided opportunities for monitoring such on scale.
The replication-competent recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety and immunogenicity testing before its use in West Africa.We performed three open-label, dose-escalation phase 1 trials one randomized, double-blind, controlled trial to assess the safety, side-effect profile, of rVSV-ZEBOV at various doses 158 healthy adults Europe Africa. All participants were injected with ranging from...
The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical severe malaria disease in infants children. We investigated whether was specific to certain parasite genotypes at locus.We used polymerase chain reaction-based next-generation sequencing DNA extracted from samples 4985 participants survey polymorphisms. evaluated effect that polymorphic positions haplotypic regions within had on first episodes 1 year after...
BackgroundThe RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with prevention of Plasmodium falciparum infection. We assessed association between anti-circumsporozoite antibody titres and magnitude duration efficacy using data from a phase 3 trial done 2009 2014.MethodsUsing 8922 African children aged 5–17 months 6537 infants 6–12 weeks at first vaccination, we analysed determinants immunogenicity after vaccination or without booster dose....
Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We pathogens individuals ≥65 years with influenza-like illness (ILI). Methods. Multiplex reverse-transcriptase polymerase chain reaction identified nasal/throat swabs from 556 episodes moderate-to-severe ILI, defined as ILI pneumonia, hospitalization, or maximum daily influenza symptom severity score (ISS) >2. Cases were selected a randomized trial an...
Artesunate is an antimalarial agent with broad anti-cancer activity in vitro and animal experiments case reports. has not been studied rigorous clinical trials for anticancer effects.To determine the effect tolerability of oral artesunate colorectal cancer (CRC).This was a single centre, randomised, double-blind, placebo-controlled trial. Patients planned curative resection biopsy confirmed primary site CRC were randomised (n = 23) by computer-generated code supplied opaque envelopes to...
Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed analyse efficacy safety of CVnCoV SARS-CoV-2 mRNA vaccine candidate.HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres ten countries Europe Latin America. By use an interactive web response system stratification by country age group (18-60 years ≥61 years), adults with no history virologically confirmed were randomly assigned (1:1)...
The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. question is whether such specificity arises from shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification host microbiota, we analyzed paired metagenomes genomes 1225 individuals Europe, Asia, Africa, including mothers children. Between countries, parallel was...
We used the RNActive® technology platform (CureVac N.V., Tübingen, Germany) to prepare CVnCoV, a COVID-19 vaccine containing sequence-optimized mRNA coding for stabilized form of SARS-CoV‑2 spike (S) protein encapsulated in lipid nanoparticles (LNP).This is an interim analysis dosage escalation phase 1 study healthy 18-60-year-old volunteers Hannover, Munich and Germany, Ghent, Belgium. After giving 2 intramuscular doses CVnCoV or placebo 28 days apart we assessed solicited local systemic...
Several studies have shown an inverse association between helminth infections and atopy, but none clearly established that the pathogens themselves, rather than other associated factors, cause suppression of atopy. To show a direct link, prospective intervention are required.A randomized, controlled trial was performed to study whether repeated anthelminthic treatment results in increased allergic sensitivity house dust mites (HDMs) chronically infected children. The population consisted 317...
Malaria parasites are sexually reproducing protozoa, although the extent of effective meiotic recombination in natural populations has been debated. If occurs frequently, compared with point mutation and mitotic rearrangement, linkage disequilibrium between polymorphic sites is expected to decline increasing distance along a chromosome. The rate this should be proportional population. Multiple covering 5-kb region chromosome 9 (the msp1 gene) have typed 547 isolates from six Africa test for...
Rapid diagnosis and accurate quantification of Plasmodium falciparum parasitemia are important for the management malaria. The assessment disease severity also depends on evaluation metabolic indexes such as blood glucose lactate concentrations. Here we describe an rapid alternative to conventional thick film examination (Lambaréné method). We assess near-patient methods measuring (OneTouch) (Accusport). accuracy Lambaréné method is similar that thin films. Results from OneTouch meter in...
ABSTRACT We compared interleukin-12 (IL-12) and other cytokine activities during after an acute clinical episode in a matched-pair case-control study of young African children who presented with either mild or severe Plasmodium falciparum malaria. The acute-phase, pretreatment plasma IL-12 alpha interferon (IFN-α) levels, as well the acute-phase mitogen-stimulated whole-blood production capacity IL-12, were significantly lower rather than addition, showed strong inverse correlations both...