A5059471407- Cardiovascular Effects of Exercise
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Child Nutrition and Water Access
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- Dialysis and Renal Disease Management
- Potassium and Related Disorders
- Animal Disease Management and Epidemiology
- Asthma and respiratory diseases
- Parasites and Host Interactions
- COVID-19 epidemiological studies
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
St George's, University of London
2016-2025
City St George's, University of London
2025
RELX Group (United States)
2020
St George’s University Hospitals NHS Foundation Trust
2015-2020
Institute of Infection and Immunity
2015-2020
University of London
2014-2019
Engineering Associates (United States)
2018
Hospital da Luz
2017
National University Heart Centre Singapore
2017
St Bartholomew's Hospital
2017
By 21 March 2020 infections related to the novel coronavirus SARS-CoV-2 had affected people from 177 countries and caused 11,252 reported deaths worldwide. Little is known about risk, presentation outcomes of (COVID-19) infection in kidney transplantation recipients, who may be at high-risk due long-term immunosuppression, comorbidity residual chronic disease. Whilst COVID-19 predominantly a respiratory disease, severe cases it can cause multi-organ failure. It unknown if immunocompromised...
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and increased risk of sudden cardiac death (SCD). Originally described as a right ventricular disease, ACM increasingly recognized biventricular entity. We evaluated pathological, genetic, clinical associations in large SCD cohort.We investigated 5205 consecutive cases referred to national pathology center between 1994 2018. Hearts tissue blocks were examined expert...
Artesunate is an antimalarial agent with broad anti-cancer activity in vitro and animal experiments case reports. has not been studied rigorous clinical trials for anticancer effects.To determine the effect tolerability of oral artesunate colorectal cancer (CRC).This was a single centre, randomised, double-blind, placebo-controlled trial. Patients planned curative resection biopsy confirmed primary site CRC were randomised (n = 23) by computer-generated code supplied opaque envelopes to...
This study aims to describe the pharmacodynamics of a fluid challenge over 10-minute period in postoperative patients.Prospective observational study.General and cardiothoracic ICU, tertiary hospital.Twenty-six patients.Two hundred fifty-milliliter performed 5 minutes. Data were recorded 10 minutes after end infusionCardiac output was measured with calibrated LiDCOplus (LiDCO, Cambridge, United Kingdom) Navigator (Applied Physiology, Sydney, Australia) obtain Pmsf analogue (Pmsa)....
The objectives of this study are to determine what is the minimal volume required perform an effective fluid challenge and investigate how different doses IV fluids in affect changes cardiac output proportion responders nonresponders.Quasi-randomized controlled trial.Cardiothoracic ICU, tertiary university hospital.Eighty postcardiac surgery patients.IV infusion 1, 2, 3, or 4 mL/Kg (body weight) crystalloid over 5 minutes.Mean systemic filling pressure measured using transient stop-flow arm...
Detecting treatment efficacy using cognitive change in trials of cerebral small vessel disease (SVD) has been challenging, making the use surrogate markers such as magnetic resonance imaging (MRI) attractive. We determined sensitivity MRI to SVD and used this information calculate sample size estimates for a clinical trial. Data from prospective SCANS (St George’s Cognition Neuroimaging Stroke) study patients with symptomatic lacunar stroke confluent leukoaraiosis was ( n = 121). Ninety-nine...
The feasibility and impact of high intensity exercise programmes in patients with hypertrophic cardiomyopathy (HCM) are unknown. This study was conducted to determine the a programme explore safety efficacy outcomes HCM. Participants were randomized 12-week supervised (n = 40) addition usual care, or care alone 40). All participants underwent assessment at baseline 12 weeks. group re-evaluated 6 months post-programme. Feasibility assessed by (i) recruitment, adherence, retention rates; (ii)...
Despite intensive ongoing research, key aspects of the spatial-temporal evolution 2001 foot and mouth disease (FMD) epidemic in Great Britain (GB) remain unexplained. Here we develop a Markov Chain Monte Carlo (MCMC) method for estimating epidemiological parameters outbreak range simple transmission models. We make simplifying assumption that infectious farms were completely observed 2001, equivalent to assuming proactively culled but not diagnosed with FMD infectious, even if some infected....
With the rise of various multidrug-resistant (MDR) pathogenic bacteria, worldwide health care is under pressure to respond. Conventional antibiotics are failing and development novel classes alternative strategies a major priority. Antimicrobial peptides (AMPs) cannot only kill MDR but also can be used synergistically with conventional antibiotics. We selected 30 short AMPs from different origins measured their synergy in combination polymyxin B, piperacillin, ceftazidime, cefepime,...
This paper develops a statistical framework for retrospective analysis well-observed livestock epidemics during which intervention policies may conceal cases, thus potentially biasing naively derived parameter and final size estimates. We apply the methods to 2001 foot mouth epidemic (FMD) in Great Britain, large number of farms (about 7500) were pre-emptively culled as part control effort without ever being diagnosed infected. infer farm-level infectivity susceptibility parameters,...
ABSTRACT The prolonged use of injectable agents in a regimen for the treatment multidrug-resistant tuberculosis (MDR-TB) is recommended by World Health Organization, despite its association with ototoxicity and nephrotoxicity. We undertook this study to look at relative adverse effects capreomycin amikacin. reviewed case notes 100 consecutive patients treated four MDR-TB centers United Kingdom. median total duration an agent was 178 days (interquartile range [IQR], 109 192 days; n = 73)...
Electrophysiological, imaging, and pathological studies have reported the presence of subtle structural abnormalities in hearts from patients with Brugada syndrome (BrS). However, data concerning disease involvement outside right ventricular outflow tract are limited. This study sought to characterize distribution myocardial fibrosis a cohort decedents experiencing sudden cardiac death caused by BrS. The authors evaluated 28 whole consecutive cases attributed BrS 29 comparator group...
The identification of H5N1 in domestic poultry Europe has increased the risk infection reaching most industrialized populations. Here, using detailed data on population Great Britain (GB), we show that currently planned interventions based movement restrictions can be expected to control majority outbreaks. probability controls fail keep an outbreak small only rises significant levels if transmission occurs via mechanisms which are both untraceable and largely independent local density...
This paper uses statistical and mathematical models to examine the potential impact of within-farm transmission dynamics on spread 2001 foot mouth disease (FMD) outbreak in Great Britain. We partly parameterize a simple within farm model using data from experimental studies FMD pathogenesis, embed this an existing between-farm model, then estimate unknown parameters (such as species-specific reproduction number) epidemic case Markov Chain Monte-Carlo (MCMC) methods. If probability detecting...
To investigate associations between ethnicity, age and sex the risk, colon distribution density scores of diverticular disease (DD).Barium enemas were examined in 1000 patients: 410 male, 590 female; 760 whites, 62 Asians, 44 black africans (BAs), 134 other blacks (OBs). Risks diverticula left-sided DD (LSDD) right-sided-component (RSCDD = right-sided + right left Pan-DD) compared using logistic regression.Four hundred forty-seven patients had (322 LSDD 125 RSCDD). Adjusted risks: (1) LSDD:...
There is paucity of literature comparing outcomes kidney transplant patients with COVID-19 to that dialysis and waitlisted patients. This report describes our data, provides comparative analysis, together a meta-analysis published studies, protocols restart the program.Data were analyzed on transplant, dialysis, tested positive for SARS-CoV-2 (nasopharyngeal swab polymerase chain reaction [PCR] test) between March 1, 2020, June 30, 16 studies.Twenty-three 1494 compared 123 1278 hemodialysis...
Abstract To investigate the symptoms of SARS-CoV-2 infection, their dynamics and discriminatory power for disease using longitudinally, prospectively collected information reported at time occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was predominant strain. Participants were assessed infection via nasal/throat PCR recruitment, vaccination appointments, when symptomatic. Statistical techniques implemented to infer estimates...
The literature contains scarce data on inequalities in growth trajectories among children born to mothers of diverse ethnoracial background the first 5 years life. We aimed investigate child according maternal group using a nationwide Brazilian database. A population-based retrospective cohort study employed linked from CIDACS Birth Cohort and Food Nutrition Surveillance System (SISVAN). Children at term, aged or younger who presented two more measurements length/height (cm) weight (kg) were...
Background There is a growing epidemic of chronic non-communicable diseases in low and middle-income countries, often attributed to urbanization, although there are limited data from marginalized rural populations. This study aimed estimate prevalence cardiometabolic associated risk factors transitional communities. Methods A cross-sectional Montubio adults aged 18–94 years living agricultural communities tropical coastal region Ecuador. Data were collected by questionnaires anthropometry,...
Background: There are few longitudinal epidemiological studies of intestinal parasitic infections (IPI) and their health effects. We studied the epidemiology determinants IPI multiparasitism during childhood using molecular methods for parasite detection analysed effects on growth hemoglobin levels. Methods: Random sample 401 children from an Ecuadorian birth cohort to 8 years. Data environmental sociodemographic characteristics were collected by questionnaires. Stool samples collected,...