A5086856789- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Hemoglobinopathies and Related Disorders
- HIV/AIDS Research and Interventions
- Multiple Myeloma Research and Treatments
- Dialysis and Renal Disease Management
- HIV/AIDS drug development and treatment
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reproductive tract infections research
- Pediatric Urology and Nephrology Studies
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Platelet Disorders and Treatments
- Erythropoietin and Anemia Treatment
- Complement system in diseases
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
King's College Hospital
2014-2025
Navrachana University
2024
Icahn School of Medicine at Mount Sinai
2016-2023
University of Southern California
2023
University of Arizona
2023
Beaumont Hospital, Royal Oak
2023
Washington University in St. Louis
2022
King's College Hospital NHS Foundation Trust
2015-2022
King's College London
2018-2022
University College London
2005-2022
By 21 March 2020 infections related to the novel coronavirus SARS-CoV-2 had affected people from 177 countries and caused 11,252 reported deaths worldwide. Little is known about risk, presentation outcomes of (COVID-19) infection in kidney transplantation recipients, who may be at high-risk due long-term immunosuppression, comorbidity residual chronic disease. Whilst COVID-19 predominantly a respiratory disease, severe cases it can cause multi-organ failure. It unknown if immunocompromised...
The orientation of the acetabular cup and position lip augmentation (if present) may improve postoperative total hip replacement stability by decreasing dislocation caused prosthesis impingement during rotation. To determine how these parameters affect dislocation, range amount rotation for two standard femoral components was determined in a Sawbones hemipelvis model. that allowed maximal were angle inclination between 35° 45° anteversion 0° 10°. Cup angles greater than 20° significantly...
Daprodustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) being investigated for the treatment of anemia CKD. In this noninferiority trial, we compared daprodustat administered three times weekly with epoetin alfa (epoetin) in patients on prevalent hemodialysis switching from prior erythropoiesis-stimulating agent (ESA).Patients baseline hemoglobin 8-11.5 g/dl receiving an ESA were randomized 2:1 to (n=270) or conventional (n=137) 52 weeks. Dosing algorithms aimed...
3% of kidney transplant recipients return to dialysis annually upon allograft failure. Development antibodies (Ab) against human leukocyte antigens (HLA) is a validated prognostic biomarker We tested whether screening for HLA Ab, combined with an intervention improve adherence and optimization immunosuppression could prevent failure.Prospective, open-labelled randomised biomarker-based strategy (hybrid) trial in 13 UK centres [EudraCT (2012-004308-36) ISRCTN (46157828)]. Patients were...
Chronic Kidney Disease (CKD) is a frequent complication in patients with multiple myeloma (MM) and associated adverse outcomes. The use of autologous stem cell transplantation (ASCT) has improved disease outcomes, however, the safety efficacy ASCT CKD been subject debate. To investigate this, we conducted retrospective analysis 370 MM who underwent their first ASCT, including those mild, moderate severe as well normal renal function at time transplant. No significant difference ASCT-related...
Up to 50% of kidney transplant patients are diagnosed with delayed graft function (DGF) following transplantation-the majority being linked ischaemia reperfusion injury (IRI). DGF is traditionally defined as the requirement for dialysis during first week after transplantation and associated inferior patient outcomes. Local synthesis complement components, largely by renal tubule, plays a critical role in IRI. We have developed Mirococept, membrane-targeted inhibitor, that can be administered...
Objectives The aims of the study were to describe gender differences in haemoglobin and albumin investigate prognostic value these measurements relation highly active antiretroviral therapy (HAART). Methods Anaemia was defined as <13.5 g/dL for men <11.5 women. Albumin <35 g/L hypoalbuminaemia. Proportional hazards models used relationships between markers HIV progression death. Results A total 291 patients had pre‐HAART 1‐year measurements. Mean levels lower women than...
Eosinophilic esophagitis (EoE) is a clinicopathological diagnosis seen in children as well adults. Growing evidence suggests that EoE strongly associated with atopic disorders. Presenting symptoms differ and adults it not known whether features vary by age. This study was designed to compare allergic sensitization between EoE. We conducted retrospective analysis of demographic clinical data from 50 (aged 2-18 years) 21-75 biopsy-proven referred our allergy clinic. Data regarding patient...
Background Interindividual variation in inosine monophosphate dehydrogenase (IMPDH) enzyme activity and adverse effects caused by mycophenolate mofetil (MMF) inhibition may be genetically determined, if so, transplant recipients should receive personalized dosing regimens of MMF, which would maximize efficacy minimize toxicity. Some studies have demonstrated a relationship between the single nucleotide polymorphism risk acute rejection with IMPDH I variants rs2278293 rs2278294 II variant...
International guidelines support an early invasive management strategy (including coronary angiography and revascularisation) for non-ST-elevation acute syndrome (NSTE-ACS) in patients with renal impairment. However, evidence from outside the UK suggests that this approach is underutilised. We aimed to describe practice within NHS, determine whether severity of dysfunction influenced provision modified association between revascularisation survival.We performed a cohort study, using...
Autologous stem cell transplantation (ASCT) and novel therapies have improved the prognosis for patients with multiple myeloma (MM). For those who undergo ASCT while on dialysis, a similar survival compared overall MM population has been reported. Therefore, achieving remission following ASCT, kidney is an attractive option, offering quality of life significant economic advantage.This case series investigates outcome five underwent subsequent between 2006 2012.Four presented end-stage renal...
We have defined HLA-DQA, DQB, DR and complement C4 variants in 92 subjects with SLE 73 controls. Subjects showed an increased frequency of HLA-DQA*0501 (P<0.01 corrected, odds ratio (OR) = 4.97; 95% C.I. 2.52−9.81), DR3 (P<0.001, OR 3.18; 1.67−6.04) C4A*QO (P<0.05, 1.91; 0.999−3.65) vs These increases were particularly marked those positive for antibodies to both Ro La. HLA-DQB*0501 0.03), DQA*0101 (P 0.0012 uncorrected, 0.23) DR7 0.0018 0.28) decreased SLE. patients disease onset prior age...
Chronic allograft nephropathy (CAN) is the most common cause of long-term renal-allograft dysfunction and second transplant loss. There are concerns that prolonged patient exposure to calcineurin inhibitors (CNIs) exacerbates or promotes process CAN.In our unit, we carried out an observational study over period 2000 2003 using low-dose mycophenolate mofetil (MMF) facilitate a phased reduction in dose CNI group patients with CAN. Low doses MMF were chosen minimize adverse effects reduce...
Half of kidney transplant recipients (KTRs) gain more than 5% their body weight in the first year following transplantation. KTRs have requested support with physical activity (PA) and prevention, but there is no routine care offered. There are few high-quality studies investigating clinical value diet, PA or combined interventions to prevent gain. The development evaluation theoretically informed complex-interventions mitigate warranted. aims this mixed-methods randomized controlled trial...
There are over 12,000 people with sickle cell disease (SCD) in the UK, and 4–12% of patients who develop Sickle Cell Nephropathy (SCN) progress to End Stage Renal Disease (ESRD). transplantation offers best outcomes for these but their access is often limited. Regular automated exchange blood transfusions (EBT) reduce complications SCD may improve outcomes. However, concerns alloimmunisation limit its widespread implementation. In this retrospective multicenter study, data were collected on...
Desmopressin acetate (DDAVP), a selective agonist of type 2 vasopressin receptors, is sometimes used prior to percutaneous renal biopsy reduce the risk bleeding complications. DDAVP increases free water reabsorption in collecting ducts, potentially leading intoxication or dilutional hyponatraemia. We present two cases, where was transplant and associated with severe hyponatraemia neurological sequelae. With being advocated many centres biopsy, these cases highlight need for increased...