A5009656263- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Viral-associated cancers and disorders
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Bone health and treatments
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Complement system in diseases
- Vasculitis and related conditions
- Lymphoma Diagnosis and Treatment
- Pregnancy and Medication Impact
- Heterotopic Ossification and Related Conditions
- Vascular Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Bone health and osteoporosis research
- Toxoplasma gondii Research Studies
- Healthcare Policy and Management
Manchester Royal Infirmary
2010-2025
Manchester University NHS Foundation Trust
2021
University of Manchester
1999-2019
Salford Royal Hospital
2000
Renal Association
2000
The prevalent renal transplant population presents an opportunity to observe the adaptive changes in alloimmune response over time, but such studies have been limited by uncertainties conventional biopsy diagnosis of T cell-mediated rejection (TCMR) and antibody-mediated (ABMR). To circumvent these limitations, we used microarrays methods investigate 703 unselected biopsies taken 3 days 35 years post-transplant from North American European centers. Using methods, diagnosed 205 specimens...
Background There is little information in the literature describing relationship between posttransplantation lymphoproliferative disorder (PTLD) incidence and presentation with both recipient Epstein-Barr virus (EBV) serostatus EBV status of PTLD histology, particularly late period. Methods This study reports largest UK single-center, single-organ analysis to date a retrospective cohort 80 cases occurring 4189 adult renal transplant recipients. Results The rate was 2.6 per 1000 patient-years...
3% of kidney transplant recipients return to dialysis annually upon allograft failure. Development antibodies (Ab) against human leukocyte antigens (HLA) is a validated prognostic biomarker We tested whether screening for HLA Ab, combined with an intervention improve adherence and optimization immunosuppression could prevent failure.Prospective, open-labelled randomised biomarker-based strategy (hybrid) trial in 13 UK centres [EudraCT (2012-004308-36) ISRCTN (46157828)]. Patients were...
Background. We carried out a retrospective study of C4d staining in paraffin sections from renal transplant biopsies to determine the association between staining, donor-specific antibodies (DSA), histological features, and graft outcome. Methods. studied 92 patients who had been biopsied for dysfunction. Biopsies were classified using Banff 97 criteria features suggestive antibody-mediated rejection noted. Paraffin stained with polyclonal antibody an immunoperoxidase technique. The presence...
Pancreas transplantation (PT) remains the only treatment that can restore insulin independence among insulin-dependent diabetics. An ageing population in developed countries has led to an increasing number of older patients who may be suitable for PT. Some investigators argue PT recipients than 50 years inferior outcome compared with younger group.The object this study was compare outcomes 31 aged and above 105 below performed between June 2001 December 2007.The incidence general...
We defined injury-induced transcriptome states in 4502 kidney transplant biopsies taken 1 day to 45 years post-transplant using genome-wide microarrays. Injury was measured by gene sets and classifiers previously developed transplants. In principal component analysis, PC1 correlated with both acute chronic injury related inflammation, PC2 time post-transplant. PC3 a novel dimension that epithelial remodeling pathways. Both reduced survival, effects strongly increasing whereas being...
A 79-year-old man, newly started on carbamazepine, presented with rash, eosinophilia and liver dysfunction progressing to acute renal failure despite discontinuation of the anti-epileptic agent. Percutaneous biopsy revealed granulomatous interstitial nephritis, which responded successfully high-dose oral steroid therapy.
Post-transplant lymphoproliferative disorder (PTLD) is a rare, serious complication following solid organ transplantation, with an incidence of 2.6 cases per 1000 patient years. Optimal treatment strategies and risk stratifications specific to kidney transplantation are lacking PTLD mortality remains high. This study investigated survival prognosis in 89 presenting over 44 years at Manchester Royal Infirmary. Patient diagnosis was 72% 6 months, 67% 1 year 54% 3 In multivariate analysis,...
Kidney transplant recipients(KTRs) are at an increased risk of venous thromboembolism (VTE) and atrial fibrillation(AF). Direct oral anticoagulants (DOACs) have shown important advantages over vitamin K antagonists; however, in KTRs, concerns regarding interactions use severe kidney disease may limit their use. This evaluation describes a large UK center's experience DOACs KTRs with CrCl > 15 mL/min.Electronic records were reviewed for all adult Manchester University Foundation Trust...
Abstract Background Renal transplantation is the best treatment for kidney failure, in terms of length and quality life cost-effectiveness. However, most transplants fail after 10 to 12 years, consigning patients back onto dialysis. Damage by immune system accounts approximately 50% failing it possible identify at risk screening presence antibodies against human leukocyte antigens. not clear how treat with antibodies. This trial will test a combined protocol renal transplant recipients....
Extended criteria donor (ECD) and donation after circulatory death (DCD) kidneys are at increased risk of delayed graft function (DGF). Experimental evidence suggests that erythropoietin (EPO) attenuates renal damage in acute kidney injury. This study piloted the administration high dose recombinant human EPO-beta implantation ECD DCD kidneys, evaluated biomarkers injury post-transplant. Forty patients were randomly assigned to receive either rhEPO-b (100,000 iu) (n = 19 intervention group,...
Chronic rejection is the single biggest cause of premature kidney graft failure. HLA antibodies (Ab) are an established prognostic biomarker for failure so there a need to test whether treatment decisions based on presence can alter prognosis. The Optimised TacrolimuS and MMF Antibodies after Renal Transplantation (OuTSMART) trial combines two elements. Firstly, testing routine screening programme Ab in all transplant recipients useful by comparing blinding versus unblinding status....
de Freitas, D.; Coupes, B.; Hoyle, Read, I.; Riad, H.; Brenchley, P. E.; Picton, M. Author Information
A 79-year-old male with chronic myelomonocytic leukaemia and extensive bilateral renal stone disease was treated intravenous rasburicase for persistent hyperuricaemia. Subsequent imaging revealed a complete dissolution of burden, avoiding the need complex, invasive surgery further replacement therapy.