A5014845271- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Global Public Health Policies and Epidemiology
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Renin-Angiotensin System Studies
- Ion channel regulation and function
- Renal Transplantation Outcomes and Treatments
- Erythropoietin and Anemia Treatment
- Potassium and Related Disorders
- Iron Metabolism and Disorders
- Genetic Associations and Epidemiology
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Parathyroid Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Pregnancy and preeclampsia studies
Kinetic Art & Technology (United States)
2024
Yale University
1995-2023
Fundacion Allende
2013-2023
Yale New Haven Hospital
2023
Shanghai Institute of Hypertension
2022
Universidad Católica de Córdoba
2000-2021
Universidad Nacional de Córdoba
2015-2021
Hospital Sant Joan de Déu Barcelona
2019
Universidad De Santander
2017
University of Mississippi Medical Center
2017
The therapeutic potential of a novel, targeted-release formulation oral budesonide (Nefecon) for the treatment IgA nephropathy (IgAN) was first demonstrated by phase 2b NEFIGAN trial. To verify these findings, 3 NefigArd trial tested efficacy and safety nine months with Nefecon (16 mg/d) versus placebo in adult patients primary IgAN at risk progressing to kidney failure (ClinicalTrials.gov: NCT03643965). NefIgArd multicenter, randomized, double-blind, placebo-controlled two-part In Part A,...
This fact sheet and call to action is supported by the World Hypertension League, Argentinian Society of Hypertension, Asia-Pacific Regional Office South Asian African Research Universities Alliance, Belgian Committee, Blue Cross Shield Louisiana, Brazilian Society, Bulgarian Caja Costarricense de Seguro Social (Costa Rican Security Fund), Cameroon Heart Foundation, Chinese Colleagues In Care, Canada, European Cardiology Council on Ibadan Center Excellence for Non-communicable Diseases,...
Daprodustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) being investigated for the treatment of anemia CKD. In this noninferiority trial, we compared daprodustat administered three times weekly with epoetin alfa (epoetin) in patients on prevalent hemodialysis switching from prior erythropoiesis-stimulating agent (ESA).Patients baseline hemoglobin 8-11.5 g/dl receiving an ESA were randomized 2:1 to (n=270) or conventional (n=137) 52 weeks. Dosing algorithms aimed...
Acute kidney injury (AKI) is a common complication during hospitalization and associated with adverse outcomes.
Abstract Hypertension is the leading risk factor for cardiovascular disease (CVD) worldwide. Despite availability of effective antihypertensive medications, control hypertension at a global level dismal, and consequently, CVD burden continues to increase. In response, countries in Latin America Caribbean are implementing HEARTS Americas, community‐based program that focuses on increasing secondary prevention through mitigation. One key pillar implementation standardized treatment protocol...
Spot urine samples with estimating equations have been used to assess individuals’ sodium (salt) intake in association health outcomes. There is large random and systematic error using this method spurious outcome associations. Substantial controversy has resulted from false claims the valid. Hence, World Hypertension League, International Society of Resolve Save Lives, supported by 21 other organizations, issued policy statement that strongly recommends research spot outcomes should not be...
Phosphate intoxication, manifested by hypocalcemic tetany and acute renal failure, may complicate bowel-cleansing preparations which contain phosphate. These are commonly used to prepare patients for various gastrointestinal procedures. Often, who receive these regimens at increased risk of phosphate intoxication from diseases slow transit or decrease excretion (renal insufficiency). We present a patient developed oliguric failure severe associated with phosphate-containing regimen.
Uremic pruritus is common among dialysis patients. Effective treatments are not readily available. Early evidence with antihistamines and gabapentin indicate variable effects.To compare the efficacy side effects of desloratadine in patients pruritus.Prospective, open-label, cross-over clinical trial 22 on chronic hemodialysis sustained over a period at least 60 days. After one-week run-in period, we assigned to three weeks either 300 mg thrice weekly or 5 weekly. washout each patient...
Increased blood pressure (BP) is the second leading risk factor for death and disability globally according to Global Burden of Disease Study.1 This work an updated version World Hypertension League (WHL) 2014 Fact sheet2 (www.whleague.org). Dr Mark Niebylski Kimbree Redburn are paid WHL consultants but report no other conflicts. Ji-Guang Wang reports receiving research grants consulting fees from several BP-measuring device companies including A&D, AVITA, Honsun, Omron, Rossmax Michael...
The K-selective channel, TOK1, recently identified in yeast, displays the unusual structural feature of having two putative pore regions, contrast to all previously cloned K channels. Using TOK1 regions as probes, we a human kidney cDNA encoding 337-amino acid protein (hKCNK1) with four transmembrane segments and containing signature sequence Amino identity is only 15% overall but 40% at pores. Northern analysis indicates high expression 1.9-kb message brain > >> heart. Nephron...
Hypertension is one of the most important risk factors for cardiovascular disease. The Global Burden Disease Study in 2010 described hypertension as leading factor global disease burden, accounting 18% all deaths and 7% disability-adjusted life years.1 Furthermore, responsible 45% caused by ischemic heart 51% stroke.2 As death disability, requires a response. Reducing uncontrolled blood pressure (BP) 25% nine United Nations targets to reduce noncommunicable diseases (NCDs) 2025.3 To that...
Background. The insertion/deletion (I/D) angiotensin-converting enzyme (ACE) polymorphism has been established as a cardiovascular risk factor in some populations, but the association with essential hypertension is controversial. Predominantly diastolic (PDH), or narrow pulse pressure hypertension, shown to have increased peripheral resistance. Because DD genotype associated higher plasma ACE levels and angiotensin II activity, we genotyped PDH patients for I/D polymorphism. Methods....
The ability to reliably evaluate the impact of interventions and changes in hypertension prevalence control is critical if burden hypertension-related disease be reduced. Previously, a World Hypertension League Expert Committee made recommendations standardize reporting population blood pressure surveys. We have added those also provide modified from Pan American Health Organization expert meeting for "performance indicators" used clinical practices. Core indicators surveys are recommended...
This work is an updated version of the WHL 2014 Dietary Salt Fact Sheet.53 Dr Mark Niebylski and Kimbree Redburn are paid consultants but report no other conflicts. Ji-Guang Wang reports receiving research grants consulting fees from several BP-measuring device companies including A&D, AViTA, Honsun, Omron, Rossmax Michael Weber a consultant for received travel support Omron All authors those International Society Hypertension conflicts interest.
Our laboratory previously cloned a novel rabbit gene ( Kcn1), expressed in kidney, heart, and aorta, predicted to encode protein with 58% amino acid identity the K channel Shaker Kv1.3 (Yao X et al. Proc Natl Acad Sci USA 92: 11711–11715, 1995). Because Kcn1 did not express well (peak current Xenopus laevis oocytes of 0.3 μA at +60 mV), human homolog (KCNA10) was isolated, its expression optimized oocytes. KCNA10 mediates voltage-gated + currents that exhibit minimal steady-state...
Introduction Although studies have examined the utility of clinical decision support tools in improving acute kidney injury (AKI) outcomes, no study has evaluated effect real-time, personalised AKI recommendations. This aims to assess impact individualised AKI-specific recommendations delivered by trained clinicians and pharmacists immediately after detection hospitalised patients. Methods analysis KAT-AKI is a multicentre randomised investigator-blinded trial being conducted across eight...