A5061701304- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Dialysis and Renal Disease Management
- Oral microbiology and periodontitis research
- Oral and gingival health research
- Neurological Complications and Syndromes
- Herpesvirus Infections and Treatments
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Full-Duplex Wireless Communications
- Pregnancy and Medication Impact
- Polyomavirus and related diseases
- Chronic Kidney Disease and Diabetes
- Transplantation: Methods and Outcomes
- Energy Harvesting in Wireless Networks
- Organ and Tissue Transplantation Research
- Inflammation biomarkers and pathways
- Ethics in Clinical Research
- Adenosine and Purinergic Signaling
- Pharmacological Effects and Toxicity Studies
- Medication Adherence and Compliance
Helsinki University Hospital
2016-2025
University of Helsinki
2007-2025
Hospital Universitari Joan XXIII de Tarragona
2025
Folkhälsans Forskningscentrum
2016-2020
Hospital Universitario Príncipe de Asturias
2020
Universidad de Cantabria
2017
Fundación Marques de Valdecilla
2014
Universitat Autònoma de Barcelona
2003
Puigvert Foundation
2003
Instituto de Tecnología Química
1988
The therapeutic potential of a novel, targeted-release formulation oral budesonide (Nefecon) for the treatment IgA nephropathy (IgAN) was first demonstrated by phase 2b NEFIGAN trial. To verify these findings, 3 NefigArd trial tested efficacy and safety nine months with Nefecon (16 mg/d) versus placebo in adult patients primary IgAN at risk progressing to kidney failure (ClinicalTrials.gov: NCT03643965). NefIgArd multicenter, randomized, double-blind, placebo-controlled two-part In Part A,...
BackgroundThe incidence of herpes zoster is up to 9 times higher in immunosuppressed solid organ transplant recipients than the general population. We investigated immunogenicity and safety an adjuvanted recombinant vaccine (RZV) renal (RT) ≥18 years age receiving daily immunosuppressive therapy.
Background Patients with end-stage kidney disease often prefer home-based dialysis due to higher self-efficacy, which relates improved medical treatment adherence. Kidney transplantation (KT) success depends on adhering immunosuppressive medication post-transplant. Objectives To investigate whether adherence post-kidney and patients’ attitudes toward immunosuppression were influenced by their prior type modality. Additionally, the study examined if patient’s towards are associated graft...
Breath ammonia (NH3) has been proposed as a potential biomarker in monitoring hemodialysis (HD) adequacy, since strong correlation between blood urea and mouth-exhaled breath NH3 observed patients with end-stage renal disease (ESRD) undergoing HD. However, the biochemical pathways for generation from have not demonstrated. In this study, we show (rs = 0.77, p < 0.001) salivary urea, indicating that levels reflect levels. Salivary is turn strongly correlated to ( + NH3) most of patients. This...
Abstract Background Triggering receptor expressed on myeloid cells (TREM‐1) is a cell‐surface involved in amplification of inflammatory response to bacterial infections, along with its ligand peptidoglycan recognition protein 1 (PGLYRP1). TREM‐1 shed by matrix metalloproteinases (MMPs) soluble (s) form. The aim the study investigate association sTREM‐1 and PGLYRP1 oral burden among patients chronic kidney disease (CKD) at predialysis posttransplantation stages. Methods One hundred forty‐four...
The total burden of infections after transplantation has not been compared in detail between recipients simultaneous pancreas-kidney (SPK) and kidney alone (KTA). We infection-related hospitalizations bacteremias during 1- 5-year follow-up among 162 patients undergoing SPK. control group consisted 153 type 1 diabetics KTA with the inclusion criteria donor recipient age &lt; 60, BMI 30. During first year, SPK had more (0.54 vs. 0.31 PPY, IRR 1.76, p = &lt;0.001) (0.11 0.01 17.12, to...
Background: Factors related to mortality of patients with chronic kidney disease (CKD) were investigated find out whether oral inflammatory burden or different etiology (diabetes nephropathy vs. other etiologies) CKD could be associated mortality. Methods: This prospective cohort study comprised 144 adults at the predialysis stage. Clinical and radiologic examination was made from 2000 2005. Patients followed up until August 2015 (complete follow‐up time: 157 months). Cause death verified 62...
Home dialysis has been associated with better patient survival compared to in-center hemodialysis. Finland over 40 years of experience home dialysis. Despite sustained efforts, the prevalence decreased in last decade. We aimed explore barriers expanding treatments from healthcare providers' and patients' perspectives. This is qualitative research, based on an electronic semi-structured survey directed nephrologists, nephrology nurses, associations. The development contemplated main shown a...
The objective of this study was to analyze factors that are involved in the progression renal allograft damage first 6 mo after transplantation. Donor and 6-mo protocol biopsies 83 patients who received a transplant were classified using Chronic Allograft Damage Index (CADI). Histologic changes compared correlated clinical parameters at transplantation, mo, annually over 2 yr. All CADI components increased significantly posttransplantation period, except chronic vascular percentage...
The pros and cons for implementing protocol biopsies (PB) after kidney transplantation are still a matter of debate. We aimed to address the frequency pathological findings in PB, analyze their impact on long-term graft survival (GS) risk factors predicting an abnormal histology.We analyzed 946 PB obtained at median time 6.5 (±2.9) months transplantation. Statistics included comparison between groups, Kaplan-Meier multinomial logistic regression analysis.PB diagnosis were: 53.4% normal; 46%...
Background. The clinical significance of kidney transplant protocol biopsies has been debated. We studied the frequency borderline changes and T cell–mediated rejection (TCMR) in 1-y standard risk recipients. Methods. Consecutive non-HLA-sensitized recipients transplants between 2006 2017, who underwent a biopsy at 1 y 2 national centers were retrospectively (N = 1546). Donor-specific HLA antibodies (DSAs), graft function (plasma creatinine), proteinuria measured time biopsy. occurrence...
OBJECTIVE To examine time trends in mortality rates and causes of death patients with type 1 diabetes end-stage renal disease on dialysis after kidney transplantation. RESEARCH DESIGN AND METHODS In a nationwide retrospective cohort analysis, all Finland who received transplant alone were compared remained dialysis. The main outcome was patient survival starting divided into dialysis, functioning transplant, loss. Causes retrieved standardized ratios calculated. RESULTS We studied 2,383...
Adolescents with a kidney transplant (KT) require special attention during the transition of care. Few longitudinal studies have assessed effect models (TM) on patient outcomes. Between 1986 and 2013, 239 pediatric patients underwent KT in Finland, whom 132 been transferred to adult In 2005, TM was developed following international recommendations. We compared (PS) graft survival (GS) rates before after introduction TM. PS GS at 10 years were similar implementation (PS 85% 90% respectively,...
Cytomegalovirus (CMV) infection remains a major challenge in solid organ transplantation. Ganciclovir has changed the prognosis, but with expense of possible viral resistance. New antiviral drugs, such as letermovir, have not been studied sufficiently kidney and pancreas transplant recipients. We reviewed abdominal transplants recipients CMV from national registry identified patients treated letermovir electronic medical records. report on treatment one three simultaneous (SPK) refractory or...