Sodiomon B. Sirima
A5040533373- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Computational Drug Discovery Methods
- Complement system in diseases
- Hemoglobinopathies and Related Disorders
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Iron Metabolism and Disorders
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Viral Infections and Outbreaks Research
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Invertebrate Immune Response Mechanisms
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Travel-related health issues
- Tuberculosis Research and Epidemiology
- Vector-borne infectious diseases
- Salmonella and Campylobacter epidemiology
- Research on Leishmaniasis Studies
- Virus-based gene therapy research
- Vaccine Coverage and Hesitancy
- Viral Infections and Vectors
Groupe de Recherche et d’Action sur le Foncier
2016-2025
Centre National de Recherche et de Formation sur le Paludisme
2015-2025
African Field Epidemiology Network
2019-2023
MalariaGEN
2015-2022
Ministry of Health
2016
Wellcome Sanger Institute
2015
Centre for Human Genetics
2015
University of Oxford
2015
Bellvitge University Hospital
2015
Centers for Disease Control and Prevention
2006
Recent gains in reducing the global burden of malaria are threatened by emergence Plasmodium falciparum resistance to artemisinins. The discovery that mutations portions a P. gene encoding kelch (K13)–propeller domains major determinant has provided opportunities for monitoring such on scale.
A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment population-wide transmission potential based on 1209 mosquito feeding assays in endemic areas Burkina Faso and Kenya. Across both sites, identified 39 individuals. In high endemicity settings, individuals were identifiable by research-grade microscopy (92.6%; 25/27), whilst one three lowest setting was detected molecular...
The malaria parasite Plasmodium falciparum invades human red blood cells by a series of interactions between host and surface proteins. By analyzing genome sequence data from populations, including 1269 individuals sub-Saharan Africa, we identify diverse array large copy-number variants affecting the invasion receptor genes GYPA GYPB We find that nearby association with severe is explained complex structural rearrangement involving loss gain two GYPB-A hybrid genes, which encode...
Abstract The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios direct typing candidate loci an additional 15,000 samples. We identify five replicable associations with levels evidence including newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth the...
The comparison of malaria indicators among populations that have different genetic backgrounds and are uniformly exposed to the same parasite strains is one approach study human heterogeneities in response infection. We report results comparative surveys on three sympatric West African ethnic groups, Fulani, Mossi, Rimaibé, living conditions hyperendemic transmission a Sudan savanna area northeast Ouagadougou, Burkina Faso. Mossi Rimaibé Sudanese negroid with long tradition sedentary...
Summary In rural, malaria‐endemic Burkina Faso, we evaluated the impact of use pre‐packaged antimalarial drugs (PPAM), by mothers in home, on progression disease children from uncomplicated fever to severe malaria. each village one province, a core group opinion leaders (mainly older mothers) was trained management malaria, including administration PPAM. Full courses (chloroquine) and antipyretic (aspirin) were packaged age‐specific bags made widely available through community health workers...
Previous studies have shown that in areas of seasonal malaria transmission, intermittent preventive treatment children (IPTc), targeting the transmission season, reduces incidence clinical malaria. However, these were conducted communities with low coverage insecticide-treated nets (ITNs). Whether IPTc provides additional protection to sleeping under an ITN has not been established.To assess whether ITN, we a randomised, double-blind, placebo-controlled trial sulphadoxine pyrimethamine (SP)...
There is longstanding evidence that immunoglobulin G (IgG) has a role in protection against clinical malaria, and human antibodies of the cytophilic subclasses are thought to be particularly critical this respect. In cohort study, 286 Burkinabè children 6 months 15 years old were kept under malaria surveillance order assess protective antibody responses four antigens which currently being evaluated as vaccine candidates: apical membrane antigen 1 (AMA1), merozoite surface protein 1-19...
Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding malaria sequence ME-TRAP conferred 67% protection against infection Plasmodium falciparum in Kenyan adults.
Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment transmission. Ivermectin (IVM) may reduce transmission by killing mosquitoes that take blood meals from IVM-treated humans.In this double-blind, placebo-controlled trial, 120 asymptomatic Plasmodium falciparum parasite carriers were randomized to receive artemether-lumefantrine (AL) plus placebo or AL a single repeated dose (200 µg/kg) of ivermectin...
In malaria-endemic countries, large proportions of infected individuals are asymptomatic, constituting a reservoir parasites for infection newly hatched mosquitoes. This study evaluated the impact screening and treatment asymptomatic carriers Plasmodium falciparum. Eighteen villages were randomized (1:1) to arms inhabitants participated in four community campaigns: three before rainy season ~1 month apart, fourth after rains at ~12 months. On day 1 campaigns 1–3, intervention arm identified...
Artemether-lumefantrine and artesunate-amodiaquine are used as first-line artemisinin-based combination therapies (ACTs) in west Africa. Pyronaridine-artesunate dihydroartemisinin-piperaquine potentially useful for diversification of ACTs this region, but further safety efficacy data required on malaria retreatment.We did a randomised, multicentre, open-label, longitudinal, controlled phase 3b/4 clinical trial at seven tertiary centres Burkina Faso, Guinea, Mali. Eligible participants first...
Abstract Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic incident infections. In the current study, we assess parasite to mosquitoes among children (aged 5–10 years) from Burkina Faso with (a) infections following clearance ( n = 48) (b) asymptomatic 60). infection cohort, 92% (44/48) of develop symptoms within 35 days, compared 23% (14/60) in cohort. All individuals carried gametocytes or developed them during follow-up, whereas only 35% (17/48) cohort...
We investigated safety, tolerability, and immunogenicity of the heterologous 2-dose Ebola vaccination regimen in healthy HIV-infected adults with different intervals between vaccinations.
Reoccurring Ebola outbreaks in West and Central Africa have led to serious illness death thousands of adults children. The objective this study was assess safety, tolerability, immunogenicity the heterologous 2-dose Ad26.ZEBOV, MVA-BN-Filo vaccination regimen adolescents children Africa.In multicentre, randomised, observer-blind, placebo-controlled Phase II study, 131 (12 17 years old) 132 (4 11 were enrolled from Eastern Western randomised 5:1 receive vaccines or placebo. Vaccine groups...
BACKGROUNDMalaria transmission-blocking vaccines aim to interrupt the transmission of malaria from one person another.METHODSThe candidates R0.6C and ProC6C share 6C domain Plasmodium falciparum sexual-stage antigen Pfs48/45. utilizes glutamate-rich protein (GLURP) as a carrier, includes second (Pfs230-Pro) short 36-amino acid circumsporozoite (CSP) sequence. Healthy adults (n = 125) malaria-endemic area Burkina Faso were immunized with 3 intramuscular injections, 4 weeks apart, 30 μg or 100...
Shigella infections remain endemic in places with poor sanitation and are a leading cause of diarrheal mortality globally, as well major contributor to gut enteropathy stunting. There currently no licensed vaccines for shigellosis but it has been estimated that an effective vaccine could avert 590,000 deaths over 20-year period. A challenge development the low immunogenicity protective efficacy candidate infants young children. Additionally, new might be less immunogenic highly setting...