A5023259606- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- Data-Driven Disease Surveillance
- Parasites and Host Interactions
- Complement system in diseases
- Travel-related health issues
- Disaster Response and Management
- HIV Research and Treatment
- Global Maternal and Child Health
- Insect Pest Control Strategies
- Historical Geography and Cartography
- Spatial Cognition and Navigation
- Computational Drug Discovery Methods
- Viral Infections and Vectors
- Artificial Intelligence in Healthcare
- Virus-based gene therapy research
- Migration, Health and Trauma
- interferon and immune responses
- COVID-19 epidemiological studies
- Child Nutrition and Water Access
- Anomaly Detection Techniques and Applications
- Microbial infections and disease research
Ministry of Public Health
2024
Centre National de Recherche et de Formation sur le Paludisme
2011-2023
Centers for Disease Control and Prevention
2023
Centre Hospitalier Universitaire Yalgado Ouédraogo
2018
Kenya Medical Research Institute
2015-2016
Previous studies have shown that in areas of seasonal malaria transmission, intermittent preventive treatment children (IPTc), targeting the transmission season, reduces incidence clinical malaria. However, these were conducted communities with low coverage insecticide-treated nets (ITNs). Whether IPTc provides additional protection to sleeping under an ITN has not been established.To assess whether ITN, we a randomised, double-blind, placebo-controlled trial sulphadoxine pyrimethamine (SP)...
Abstract Background The World Health Organization recommends regularly assessing the efficacy of artemisinin-based combination therapy (ACT), which is a critical tool in fight against malaria. This study evaluated two combinations recommended to treat uncomplicated Plasmodium falciparum malaria Burkina Faso three sites: Niangoloko, Nanoro, and Gourcy. Methods was two-arm randomized control trial artemether-lumefantrine (AL) dihydroartemisinin-piperaquine (DP). Children aged 6–59 months old...
Targeted malaria control interventions are expected to be cost-effective. Clinical, parasitological and serological markers of transmission have been used detect hotspots, but few studies examined the relationship between different potential in low areas. The present study reports on relationships clinical, parasitological, entomological an area intensity Coastal Kenya. Longitudinal data collected from 831 children aged 5–17 months, cross-sectional survey 800 older adults, Ganze Kenyan Coast...
BackgroundAd35.CS.01 is a pre-erythrocytic malaria candidate vaccine. It codon optimized nucleotide sequence representing the P. falciparum circumsporozoite (CS) surface antigen inserted in replication deficient Adenovirus 35 backbone. A Phase 1a trial has been conducted USA naïve adults and showed that vaccine was safe. The aim of this study to assess safety immunogenicity ascending dosages sub Saharan Africa. MethodsA double blind, randomized, controlled, dose escalation, phase Ib rural...
Background The aim of this study was to determine the incidence and seasonal pattern malaria in children South-West Burkina Faso, compare, a randomized trial, characteristics cases detected by active passive surveillance. This also enabled planning vaccine trial. Methods Households with young children, located within 5 kilometers health facility, were one two surveillance methods. In first group, monitored actively. Each child visited twice weekly; tympanic temperature measured, if had fever...
Background Children below six months are reported to be less susceptible clinical malaria. Maternally derived antibodies and foetal haemoglobin important putative protective factors. We examined Plasmodium falciparum merozoite surface protein 3 (MSP3) glutamate-rich (GLURP), in children their first two years of life Burkina Faso risk Methods A cohort 140 infants aged between four weeks was recruited a stable transmission area south-western monitored for 24 by active passive surveillance....
Background Interventions that reduce exposure to malaria infection may lead delayed morbidity and mortality. We investigated whether intermittent preventive treatment of in children (IPTc) was associated with an increase the incidence after cessation intervention. Methods An individually randomised, trial IPTc, comparing three courses sulphadoxine pyrimethamine (SP) plus amodiaquine (AQ) placebos implemented aged 3–59 months during 2008 transmission season Burkina Faso. All were given a long...
Young infants are less susceptible to severe episodes of malaria but the targets and mechanisms protection not clear. Cord blood antibodies may play an important role in mediating many studies have examined their association with outcome infection or non-severe malaria. Here, we investigated whether cord IgG Plasmodium falciparum merozoite antigens antibody-mediated effector functions were associated reduced odds developing at different time points during first year life. We conducted a...
Abstract Background The Democratic Republic of the Congo (DRC) experienced its largest Ebola Virus Disease Outbreak in 2018–2020. As a result outbreak, significant funding and international support were provided to Eastern DRC improve disease surveillance. Integrated Surveillance Response (IDSR) strategy has been used as framework strengthen public health surveillance, full implementation could be critical continues face threats various epidemic-prone diseases. In 2021, initiated an IDSR...
Young infants have reduced susceptibility to febrile malaria compared with older children, but the mechanism for this remains unclear. There are conflicting data on role of passively acquired antibodies. Here, we examine antibody titres merozoite surface antigens in protection children their first two years life settings differing transmission intensity and compare these previously established protective thresholds. Two cohorts aged four six weeks were recruited Banfora, Burkina Keur Soce,...
Reducing the 2015 level of malaria mortality by 90% 2030 is a goal set World Health Organization (WHO). In Burkina Faso, several control programs proven to be effective were implemented over last decade. parallel, progressive strengthening health surveillance system generating valuable data, which represents great opportunity for analyzing trends in burden and assessing effect these programs. Complementary rolled out at different time points paces, present work aims investigating both...
Vector control tools have contributed significantly to a reduction in malaria burden since 2000, primarily through insecticidal-treated bed nets (ITNs) and indoor residual spraying. In the face of increasing insecticide resistance key vector species, global progress has stalled. Innovative tools, such as dual active ingredient (dual-AI) ITNs that are effective at killing insecticide-resistant mosquitoes recently been introduced. However, large-scale uptake slow for several reasons, including...
Prior to a chimpanzee adenovirus-based (ChAd63) malarial vaccine trial, sera were collected assess ChAd63-specific neutralizing antibody titers in Banfora (Burkina Faso). The low reported both adults and children (median titers, 139.1 35.0, respectively) are encouraging for the potential use of ChAd63 as vector.
In West Africa, identification of nonmalarial acute febrile illness (AFI) etiologic pathogens is challenging, given limited epidemiologic surveillance and laboratory testing, including for AFI caused by arboviruses. Consequently, public health action to prevent, detect, respond outbreaks constrained, as experienced during dengue in several African countries. We describe the successful implementation laboratory-based arbovirus sentinel a outbreak Burkina Faso fall 2017. implementation,...
Abstract As part of the New Nets Project, new insecticide-treated net (ITN) types, Interceptor® G2 (BASF) (IG2) and PermaNet® 3.0 (Vestergaard SA) (PBO), were included in a select number districts during 2019 universal coverage campaign Burkina Faso. This manuscript describes results observational study that accompanied IG2 PBO distributions, designed to evaluate their effectiveness incremental cost-effectiveness compared standard pyrethroid-only ITNs (Interceptor®) unique Burkinabe context....
Volume 21, no. 6, p. 901–903, 2014. Page 902, column 1: The following paragraph was inadvertently omitted from the Acknowledgments section. This work supported by an award European and Developing Countries Clinical Trials Partnership (EDCTP) performed Malaria Vectored
Abstract Background The Democratic Republic of the Congo (DRC) experienced its largest Ebola Virus Disease Outbreak in 2018-2020. As a result outbreak, significant funding and international support were provided to Eastern DRC improve disease surveillance. Integrated Surveillance Response (IDSR) strategy has been used as framework strengthen public health surveillance, full implementation could be critical continues face threats various epidemic-prone diseases. In 2021, initiated an IDSR...
Abstract Background In 2010, the Government of Sierra Leone has implemented Free Health Care Initiative (FHCI) in country with objective to reduce under five mortality. The biggest share this mortality is attributable infectious diseases. Care-seeking for children a key point due diseases as it permits early diagnosis and prompt correct treatment. study was therefore assess trend prevalence care-seeking well identify determinants utilization healthcare services by under-five (U5) caregivers...