A5033484754- Malaria Research and Control
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Travel-related health issues
- Parasites and Host Interactions
- Hemoglobinopathies and Related Disorders
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Sepsis Diagnosis and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- Pancreatitis Pathology and Treatment
- Anesthesia and Pain Management
- Nutrition and Health in Aging
- SARS-CoV-2 detection and testing
- COVID-19 diagnosis using AI
- Zoonotic diseases and public health
- Dengue and Mosquito Control Research
- Invertebrate Immune Response Mechanisms
- Virology and Viral Diseases
Institut de Recherche en Sciences de la Santé
2021-2023
Centre National de la Recherche Scientifique et Technologique
2021-2023
Hôpital Avicenne
2022
Centre National de Recherche et de Formation sur le Paludisme
2009-2021
Université Joseph Ki-Zerbo
2020
Centre Hospitalier Universitaire Yalgado Ouédraogo
2020
Association pour la Recherche en Physiologie de l’Environnement
2020
Previous studies have shown that in areas of seasonal malaria transmission, intermittent preventive treatment children (IPTc), targeting the transmission season, reduces incidence clinical malaria. However, these were conducted communities with low coverage insecticide-treated nets (ITNs). Whether IPTc provides additional protection to sleeping under an ITN has not been established.To assess whether ITN, we a randomised, double-blind, placebo-controlled trial sulphadoxine pyrimethamine (SP)...
Abstract Background The World Health Organization recommends regularly assessing the efficacy of artemisinin-based combination therapy (ACT), which is a critical tool in fight against malaria. This study evaluated two combinations recommended to treat uncomplicated Plasmodium falciparum malaria Burkina Faso three sites: Niangoloko, Nanoro, and Gourcy. Methods was two-arm randomized control trial artemether-lumefantrine (AL) dihydroartemisinin-piperaquine (DP). Children aged 6–59 months old...
A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to achieve parasite killing vitro, while phase Ib semi-immune adult Burkina Faso confirmed was safe. The aim this study assess safety and immunogenicity children aged 12-24 months living malaria endemic area Faso.The double-blind, randomized, controlled, dose escalation trial, designed...
Malariometric parameters are often primary endpoints of efficacy trials malaria vaccine candidates. This study aims to describe the epidemiology prior conduct a series drug and in rural area Burkina Faso.Malaria incidence was prospectively evaluated over one year follow-up among two cohorts children aged 0-5 years living Saponé health district. The parents 1089 comprising passive case detection cohort were encouraged seek care from local clinic at any time their child felt sick. Among this...
BackgroundAd35.CS.01 is a pre-erythrocytic malaria candidate vaccine. It codon optimized nucleotide sequence representing the P. falciparum circumsporozoite (CS) surface antigen inserted in replication deficient Adenovirus 35 backbone. A Phase 1a trial has been conducted USA naïve adults and showed that vaccine was safe. The aim of this study to assess safety immunogenicity ascending dosages sub Saharan Africa. MethodsA double blind, randomized, controlled, dose escalation, phase Ib rural...
Background The aim of this study was to determine the incidence and seasonal pattern malaria in children South-West Burkina Faso, compare, a randomized trial, characteristics cases detected by active passive surveillance. This also enabled planning vaccine trial. Methods Households with young children, located within 5 kilometers health facility, were one two surveillance methods. In first group, monitored actively. Each child visited twice weekly; tympanic temperature measured, if had fever...
Malariometric information is needed to decide how introduce malaria vaccines and evaluate their impact in sub-Saharan African countries. This cross-sectional study (NCT01954264) was conducted between October November, 2013, corresponding the high transmission season, four sites with Health Demographic Surveillance Systems (DSS) [two moderate-to-high endemicity Burkina Faso (Nouna Saponé) two low Senegal (Keur Socé Niakhar)]. Children (N = 2421) were randomly selected from DSS lists of...
Background Interventions that reduce exposure to malaria infection may lead delayed morbidity and mortality. We investigated whether intermittent preventive treatment of in children (IPTc) was associated with an increase the incidence after cessation intervention. Methods An individually randomised, trial IPTc, comparing three courses sulphadoxine pyrimethamine (SP) plus amodiaquine (AQ) placebos implemented aged 3–59 months during 2008 transmission season Burkina Faso. All were given a long...
Abstract Background Genetic factors play a key role in determining resistance/susceptibility to infectious disease. Susceptibility of the human host malaria infection has been reported be influenced by genetic factors, which could confounders if not taken into account assessment efficacy interventions against malaria. This study aimed assess relationship between haemoglobin genotypes and children under five years site being characterized for future vaccine trials. Methods The population...
Treatment of confirmed malaria patients with Artemisinin-based Combination Therapy (ACT) at remote areas is the goal many anti-malaria programs. Introduction effective and affordable Rapid Diagnosis Test (RDT) in could be an alternative tool for case management. This study aimed to assess performance OptiMAL dipstick rapid diagnosis children under five.Malaria symptomatic asymptomatic were recruited a passive manner two community clinics (CCs). Malaria by microscopy RDT performed....
During the season of high malaria transmission, most children are infected by Plasmodium, which targets red blood cells (RBCs), affecting haematological parameters. To describe these variations, we examined profiles two groups living in a malaria-endemic area. A cross-sectional survey was conducted at peak transmission rural area Burkina Faso. After informed consent and clinical examination, samples were obtained from participants for diagnosis full count. Of 414 included analysis, 192 not...
Fulani ethnic group individuals are less susceptible than sympatric Mossi group, in term of malaria infection severity, and differ antibody production against antigens. The differences susceptibility to between groups thought be regulated by different genetic backgrounds offer the opportunity compare haematological parameters, Tregs γδT cell profiles seasonal stable transmission settings Burkina Faso. study was conducted at two time points i.e. during high low period.Two cross-sectional...
Though chloroquine derivatives are used in the treatment of coronavirus disease 2019 (COVID-19) many countries worldwide, doubts remain about safety and efficacy these drugs, especially African communities where published data scarce.We conducted an observational prospective cohort study from April 24 to September 03, 2020, Burkina Faso assess (as primary outcome) clinical, biological, cardiac (electrocardiographic) or hydroxychloroquine plus azithromycin administered COVID-19 patients. The...
Dengue fever (DF) is endemic in Burkina Faso, with 70% of its burden supported by the Central Health Region. Then, a single confirmed case can no longer mean an epidemic. This study aimed at describing trends and setting epidemic thresholds DF Region.An ecological was conducted using monthly data from surveillance between 2016 2021. Three methods were applied to set alert intervention incidence rate: [mean + 2 SD], median [3rd quartile] cumulative sum (C-sum) [C-sum 1.96 SD]. These plotted...
Abstract Background This study aimed to estimate the anti‐SARS‐CoV‐2 antibody seroprevalence in general population of Bobo‐Dioulasso and Ouagadougou (Burkina Faso). Methods We collected from March April 2021 blood samples randomly selected residents both main cities based on World Health Organization (WHO) sero‐epidemiological investigations protocols tested them with WANTAI SARS‐CoV‐2 total antibodies enzyme‐linked immunosorbent assay (ELISA) kits intended for qualitative assessment. also...
Abstract Background The world has high hopes of vaccination against COVID-19 to protect the population, boost economies and return normal life. Vaccination programmes are being rolled out in income countries, but pandemic continues progress many low-and middle-income countries (LMICs) despite implementation strict hygiene measures. We aim present a comprehensive research protocol that will generate epidemiological, sociological anthropological data about epidemic Burkina Faso, landlocked...
ObjectivesOur study aimed to assess the statistical relationship between use of chloroquine phosphate or hydroxychloroquine plus azithromycin (CQ/HCQ + AZ) and virological recovery, disease worsening, death among out- inpatients with COVID-19 in Burkina Faso.Methods DesignsThis was a retrospective observational that compared outcomes terms time patients who received CQ/HCQ AZ those did not using multivariable Cox Poisson model before after propensity matching.ResultsOf 863 included study,...
Background: A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to achieve parasite killing vitro, while phase Ib semi-immune adult Burkina Faso confirmed was safe.The aim this study assess safety and immunogenicity children aged 12-24 months living malaria endemic area Faso. Methods:The double-blind, randomized, controlled, dose escalation...
Abstract Background Early data on COVID-19 (based primarily PCR testing) indicated a low burden in Sub-Saharan Africa. To better understand this, this study aimed to estimate the incidence rate and identify predictors of SARS-CoV-2 seroconversion two largest cities Burkina Faso. This is part EmulCOVID-19 project (ANRS-COV13). Methods Our utilized WHO Unity protocol for cohort sero-epidemiological studies general population. We conducted random sampling stratified by age group sex....
In Burkina Faso, the health system is characterized by systemic insufficient and antiquated health-care infrastructures. Consequently, few establishments have required resources to diagnose manage patients with COVID-19, fewer still intensive care facilities for severely ill COVID. Furthermore, there a widespread scarcity of qualified staff. The aim this study was explore experiences COVID-19 who recovered after being cared in Bobo Dioulasso Ouagadougou. Using individual semistructured...
ABSTRACT Objective: The aim of this study was to evaluate the frequency post operative vomiting after abdominal wall surgery and identify risk factors. Patients method: This is a descriptive analytical cross-sectional study. conducted at Ouahigouya University Hospital between 2020 2022. It included all patients aged 18 over, in whom (hernia eventration) performed. clinical data were compared group who presented postoperative those did not present vomiting. Results: 256 Their average age 44.1...