Jean‐Bosco Ouédraogo
A5005371655- Malaria Research and Control
- Mosquito-borne diseases and control
- Child Nutrition and Water Access
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Parasites and Host Interactions
- Global Maternal and Child Health
- Agriculture and Rural Development Research
- Insect Pest Control Strategies
- Iron Metabolism and Disorders
- Trace Elements in Health
- Invertebrate Immune Response Mechanisms
- Influenza Virus Research Studies
- Trypanosoma species research and implications
- Hepatitis C virus research
- Child Nutrition and Feeding Issues
- Parasitic Diseases Research and Treatment
- Tuberculosis Research and Epidemiology
- African Studies and Ethnography
- African Botany and Ecology Studies
- HIV Research and Treatment
- Insect symbiosis and bacterial influences
- Ethnobotanical and Medicinal Plants Studies
- Insect Resistance and Genetics
- Hemoglobinopathies and Related Disorders
Institut de Recherche en Sciences de la Santé
2016-2025
Université Joseph Ki-Zerbo
2006-2025
University of Oxford
2023
Institut de l'Environnement et Recherches Agricoles
2004-2023
Centre National de la Recherche Scientifique et Technologique
2004-2023
Yale University
2020-2023
Centre for Human Genetics
2023
Centre Muraz
2006-2022
Nazi Boni University
2014-2022
École des hautes études en sciences sociales
2015-2020
An ongoing phase 3 study of the efficacy, safety, and immunogenicity candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries.From March 2009 through January 2011, we enrolled 15,460 children two age categories--6 to 12 weeks 5 17 months age--for vaccination with either or a non-malaria comparator vaccine. The primary end point analysis was efficacy against clinical during after first 6000 at enrollment who received all three doses according protocol. After 250 had...
The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe in children 5 to 17 months age by approximately 50% an ongoing phase 3 trial. We studied infants 6 12 weeks recruited for the same
Recent gains in reducing the global burden of malaria are threatened by emergence Plasmodium falciparum resistance to artemisinins. The discovery that mutations portions a P. gene encoding kelch (K13)–propeller domains major determinant has provided opportunities for monitoring such on scale.
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the component partner drug. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter ( pfcrt ) P. multidrug 1 pfmdr1 genes are associated with decreased sensitivity to amodiaquine lumefantrine, but effects of these polymorphisms therapeutic responses artesunate-amodiaquine (ASAQ) artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 trials were...
Abstract Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify presence antibiotics in blood malaria-infected people as a new increasing transmission. We show that ingested enhance susceptibility Anopheles gambiae mosquitoes to malaria infection disturbing their gut microbiota. This effect confirmed semi-natural setting feeding with children...
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions Africa.We conducted an individually randomized, controlled trial to assess whether seasonal vaccination with RTS,S/AS01E was noninferior chemoprevention preventing uncomplicated malaria two interventions combined were superior either one alone severe malaria-related outcomes.We randomly assigned 6861 children 5 17 months age receive sulfadoxine-pyrimethamine amodiaquine (2287 [chemoprevention-alone group]),...
BackgroundRecently, we found that a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical with seasonal administration in phase 2b trial Burkina Faso. Here, report on safety and of the vaccine 3 enrolling 4800 children across four countries followed for up to 18 months at sites 12 standard sites.MethodsWe did double-blind, randomised, R21/Matrix-M five African differing transmission intensities seasonality. Children (aged 5–36 months) were enrolled randomly assigned (2:1)...
Metabolism of the antimalarial drug amodiaquine (AQ) into its primary metabolite, N-desethylamodiaquine, is mediated by CYP2C8. We studied frequency CYP2C8 variants in 275 malaria-infected patients Burkina Faso, metabolism AQ variants, and impact other drugs on metabolism. The allele frequencies CYP2C8*2 CYP2C8*3 were 0.155 0.003, respectively. No evidence was seen for influence genotype efficacy or toxicity, but sample size limited these assessments. variant most common Africans, CYP2C8*2,...
Malaria control programs are being jeopardized by the spread of insecticide resistance in mosquito vector populations. The situation Burkina Faso is emblematic with Anopheles gambiae populations showing high levels to most available compounds. Although frequency target-site mutations including knockdown (kdr) and insensitive acetylcholinesterase (Ace-1R) alleles has been regularly monitored area, it not known whether detoxifying enzymes contribute diversity phenotypes observed field. Here,...
Our understanding of the composition multi-clonal malarial infections and epidemiological factors which shape their diversity remain poorly understood. Traditionally within-host has been defined in terms multiplicity infection (MOI) derived by PCR-based genotyping. Massively parallel, single molecule sequencing technologies now enable individual read counts to be on genome-wide datasets facilitating development new statistical approaches describe diversity. In this class measures FWS metric...
Small-quantity lipid-based nutrient supplements (SQ-LNS) are promising home fortification products, but the optimal zinc level needed to improve growth and reduce morbidity is uncertain. We aimed assess impact of providing SQ-LNS with varied amounts zinc, along illness treatment, on zinc-related outcomes compared standard care. In a placebo-controlled, cluster-randomized trial, 34 communities were stratified intervention (IC) or non-intervention cohorts (NIC). 2435 eligible IC children...
Abstract Malaria is a major public health problem that actively being addressed in global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant new regions. A simple genetic marker quickly accurately identifies geographic origin infections would be valuable tool for locating source imported outbreaks. Here we analyse mitochondrion apicoplast genomes 711...
Artemether-lumefantrine and artesunate-amodiaquine are used as first-line artemisinin-based combination therapies (ACTs) in west Africa. Pyronaridine-artesunate dihydroartemisinin-piperaquine potentially useful for diversification of ACTs this region, but further safety efficacy data required on malaria retreatment.We did a randomised, multicentre, open-label, longitudinal, controlled phase 3b/4 clinical trial at seven tertiary centres Burkina Faso, Guinea, Mali. Eligible participants first...
<h2>Summary</h2><h3>Background</h3> Seasonal vaccination with the RTS,S/AS01<sub>E</sub> vaccine combined seasonal malaria chemoprevention (SMC) prevented in young children more effectively than either intervention given alone over a 3 year period. The objective of this study was to establish whether added protection provided by combination could be sustained for further 2 years. <h3>Methods</h3> This double-blind, individually randomised, controlled, non-inferiority and superiority, phase...
Background: Developing malaria vaccines has proved difficult with many challenges, including polymorphic antigens, modest field-trial efficacy, and now limitations on vaccine supply preventing widespread impact. RTS,S/AS01, the most effective candidate to date, demonstrated 56% efficacy against uncomplicated clinical over 12 months in a licensure trial African children. Recently, we found that new R21 nanoparticle saponin adjuvant Matrix-M™ showed 75% similar endpoint seasonal administration...
The R21/Matrix-M vaccine has demonstrated high efficacy against Plasmodium falciparum clinical malaria in children sub-Saharan Africa. Using trial data, we aimed to estimate the public health impact and cost-effectiveness of introduction across
Summary White fonio ( Digitaria exilis ) and California blackeye cowpea Vigna unguiculata flours were used in sugar cookie preparation. Formulations were: (1) 100% wheat, (2) 50% wheat/50% fonio, (3) cowpea, (4) 33% wheat/33% fonio/33% (5) 25% wheat/75% (6) fonio/25% (7) 75% (8) fonio/50% cowpea. The wheat cookies had the greatest spread ratio (5.86) wheat/25% least (4.39). required most force (720.3 N) to shear (399.4 N). lightest colour darkest. Sensory panel assessments of appearance,...
In Africa, highly pathogenic avian influenza H5N1 virus was first detected in northern Nigeria and later also other regions of the country. Since then, seven African countries have reported infections. This study reports a comparison full-length genomic sequences isolates from chicken farms hooded vultures Burkina Faso with earlier outbreaks worldwide. addition, antigenicity Nigerian compared strains. All strains clustered within three sublineages denominated A (south-west Nigeria, Niger), B...