A5076130506- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Inflammatory mediators and NSAID effects
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Eicosanoids and Hypertension Pharmacology
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Glaucoma and retinal disorders
- Hepatitis B Virus Studies
- Rabies epidemiology and control
- Nitric Oxide and Endothelin Effects
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Hepatitis C virus research
- Ocular Surface and Contact Lens
- Hydrological Forecasting Using AI
- Ocular Diseases and Behçet’s Syndrome
- Corneal Surgery and Treatments
- Streptococcal Infections and Treatments
- Malaria Research and Control
Serum Institute of India (India)
2016-2025
University of Agricultural Sciences Raichur
2018-2025
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2025
Veterinary Biological and Research Institute
2007-2024
Institute of Medical Sciences
2023
Dr. Babasaheb Ambedkar Marathwada University
2023
Banaras Hindu University
2023
Syngene International (India)
2022
University of Mumbai
2022
B.J. Medical College
2021
BackgroundRecently, we found that a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical with seasonal administration in phase 2b trial Burkina Faso. Here, report on safety and of the vaccine 3 enrolling 4800 children across four countries followed for up to 18 months at sites 12 standard sites.MethodsWe did double-blind, randomised, R21/Matrix-M five African differing transmission intensities seasonality. Children (aged 5–36 months) were enrolled randomly assigned (2:1)...
Exogenous prostaglandin (PGE 2 ) contracts bovine and human coronary arteries but its precursor, arachidonic acid, relaxes them. The endoperoxides PGH 3 relax strips, 1 produces contraction. primary prostaglandins exert opposite effects to their own endoperoxide precursors, thus, PGE contract, the arteries. paradoxical dilation produced by arachidonate or suggest that little if any isomerase which converts into exists, a novel, potent, PG-like substance is isolated Although coronaries do not...
Group A meningococci are the source of major epidemics meningitis in Africa. An affordable, highly immunogenic meningococcal conjugate vaccine is needed.We conducted two studies Africa to evaluate a new MenA (PsA-TT). In study A, 601 children, 12 23 months age, were randomly assigned receive PsA-TT, quadrivalent polysaccharide reference (PsACWY), or control (Haemophilus influenzae type b [Hib-TT]). Ten later, these children underwent another round randomization within each group full dose...
Rotavirus is the most common cause of moderate-to-severe infant diarrhoea in developing countries, resulting enormous morbidity, mortality, and economic burden. A bovine-human reassortant pentavalent rotavirus vaccine (BRV-PV) targeting globally strains was developed India tested a randomized, double-blind, placebo-controlled end-point driven Phase III efficacy clinical trial implemented at six sites across India. Infants 6 to 8 weeks age were randomized (1:1) receive three oral doses BRV-PV...
An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African belt. Data on safety and immunogenicity of NmCV-5, a pentavalent targeting A, C, W, Y, X serogroups, have been limited.
Background: Developing malaria vaccines has proved difficult with many challenges, including polymorphic antigens, modest field-trial efficacy, and now limitations on vaccine supply preventing widespread impact. RTS,S/AS01, the most effective candidate to date, demonstrated 56% efficacy against uncomplicated clinical over 12 months in a licensure trial African children. Recently, we found that new R21 nanoparticle saponin adjuvant Matrix-M™ showed 75% similar endpoint seasonal administration...
Mumps epidemics in Canada and the United States prompted us to review evidence for effectiveness of 5 different vaccine strains. Early trials with Jeryl Lynn strain demonstrated an efficacy approximately 95%, but epidemic conditions, has been as low 62%; this is still considerably better than another safe strain, Rubini (which close 0% conditions). The Urabe 54%-87% prone cause aseptic meningitis. Little epidemiological information available other vaccines. Leningrad-Zagreb which widely used...
<b><i>Background and Aims:</i></b> Malnutrition is associated with poor clinical outcomes. Whether there a causal relationship or it merely mirrors severe patient condition remains unclear. We examined the association of malnutrition biomarkers characteristic different pathophysiological states to better understand underlying etiological mechanisms. <b><i>Methods:</i></b> prospectively followed consecutive adult medical inpatients....
Aerosolized vaccine can be used as a needle-free method of immunization against measles, disease that remains major cause illness and death. Data on the immunogenicity aerosolized measles in children are inconsistent.We conducted an open-label noninferiority trial involving 9.0 to 11.9 months age India who were eligible receive first dose vaccine. Children randomly assigned single by means either aerosol inhalation or subcutaneous injection. The primary end points seropositivity for...
Only a small proportion of blood cultures routinely performed in emergency department (ED) patients is positive. Multiple clinical scores and biomarkers have previously been examined for their ability to predict bacteremia. Conclusive validation these essential. This observational cohort study included with suspected infection who had culture sampling at ED admission. We assessed 5 admission concentrations procalcitonin (PCT), C-reactive protein (CRP), lymphocyte white cell counts, the...
Lack of access to rabies immunoglobulin (RIG) contributes high mortality. A recombinant human monoclonal antibody (SII RMAb) was tested in a postexposure prophylaxis (PEP) regimen comparison with RIG (HRIG)-containing PEP regimen.This phase 2/3, randomized, single-blind, noninferiority study conducted 200 participants World Health Organization category III suspected exposures. Participants received either SII RMAb or HRIG (1:1 ratio) wounds and, if required, intramuscularly on day 0, along 5...
We have reported previously that thromboxane A2 (TXA2) and serotonin (5-HT, 5-hydroxytryptamine) are important mediators of cyclic flow variations (CFVs) in a canine model coronary artery stenosis endothelial injury. The present study tested the hypothesis TXA2 receptor antagonist is more effective reducing intracoronary platelet deposition at sites injury severe than 5-HT2 antagonist. CFVs developed after placing plastic constrictor around left anterior descending (LAD) 51 56 dogs....