Fadima Cheick Haidara
A5055766948- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Global Maternal and Child Health
- Viral Infections and Vectors
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- Escherichia coli research studies
- Healthcare Policy and Management
- Long-Term Effects of COVID-19
- Healthcare Systems and Reforms
- Hepatitis Viruses Studies and Epidemiology
- Vibrio bacteria research studies
- Ethics in Clinical Research
- Psoriasis: Treatment and Pathogenesis
- Child Nutrition and Feeding Issues
Centre Pour le Développement des Vaccins-Mali
2016-2025
World Health Organization
2022
Ministère de la Santé et de l'Hygiène Publique
2015
Despite the heightened risk of serious influenza during infancy, vaccination is not recommended in infants younger than 6 months. We aimed to assess safety, immunogenicity, and efficacy maternal immunisation with trivalent inactivated vaccine for protection against a first episode laboratory-confirmed influenza.We did this prospective, active-controlled, observer-blind, randomised phase 4 trial at six referral centres community health Bamako, Mali. Third-trimester pregnant women (≥28 weeks'...
The 2014 west African Zaire Ebola virus epidemic prompted worldwide partners to accelerate clinical development of replication-defective chimpanzee adenovirus 3 vector vaccine expressing glycoprotein (ChAd3-EBO-Z). We aimed investigate the safety, tolerability, and immunogenicity ChAd3-EBO-Z in Malian US adults, assess effect boosting Malians with modified vaccinia Ankara other filovirus antigens (MVA-BN-Filo).
Group A meningococci are the source of major epidemics meningitis in Africa. An affordable, highly immunogenic meningococcal conjugate vaccine is needed.We conducted two studies Africa to evaluate a new MenA (PsA-TT). In study A, 601 children, 12 23 months age, were randomly assigned receive PsA-TT, quadrivalent polysaccharide reference (PsACWY), or control (Haemophilus influenzae type b [Hib-TT]). Ten later, these children underwent another round randomization within each group full dose...
The occurrence of Ebola virus (EBOV) in West Africa during 2013-2015 is unprecedented. Early reports suggested that this outbreak EBOV mutating twice as fast previously observed, which indicates the potential for changes transmissibility and virulence could render current molecular diagnostics countermeasures ineffective. We have determined additional full-length sequences from two clusters imported infections into Mali, we show nucleotide substitution rate (9.6 × 10(-4) substitutions per...
An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African belt. Data on safety and immunogenicity of NmCV-5, a pentavalent targeting A, C, W, Y, X serogroups, have been limited.
Abstract Background Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, precursor to stunting lifelong morbidity. Several promising vaccines are in development field efficacy trials will require consortium potential vaccine trial sites with up-to-date diarrhea incidence data. Methods The Enterics for Global Health (EFGH) surveillance study employ facility-based enrollment cases aged 6–35 months 3 follow-up establish rates document...
Maternal influenza immunisation can reduce morbidity and mortality associated with infection in pregnant women young infants. We aimed to determine the vaccine efficacy of maternal against infant PCR-confirmed influenza, duration protection, effect gestational age at vaccination on efficacy, birth outcomes, growth up 6 months age.We did a pooled analysis three randomised controlled trials done Nepal (2011-2014), Mali South Africa (2011-2013). Pregnant women, 17-34 weeks Nepal, 28 or more...
Respiratory syncytial virus (RSV) is a leading cause of viral pneumonia and bronchiolitis during the first 6 months life. Placentally transferred antibodies can prevent severe RSV illness, maternal immunization may reduce illness in young infants. Identification protective antibody levels facilitates advancement vaccine candidates immunization.We conducted nested case-control study with 587 Malian mother-infant pairs, followed from birth to age months. cases were infants who developed...
Abstract Background Bacterial pathogens cause substantial diarrhea morbidity and mortality among children living in endemic settings, yet antimicrobial treatment is only recommended for dysentery or suspected cholera. Methods AntiBiotics Children with severe Diarrhea was a 7-country, placebo-controlled, double-blind efficacy trial of azithromycin 2–23 months age watery accompanied by dehydration malnutrition. We tested fecal samples enteric utilizing quantitative polymerase chain reaction to...
World Health Organization (WHO) guidelines do not recommend routine antibiotic use for children with acute watery diarrhea. However, recent studies suggest that a significant proportion of such episodes have bacterial cause and are associated mortality growth impairment, especially among at high risk diarrhea-associated mortality. Expanding dehydrated or undernourished may reduce improve growth.To determine whether the addition azithromycin to standard case management nonbloody diarrhea aged...
While maternal pertussis vaccination is a strategy to reduce infant morbidity, safety and immunogenicity data are limited in sub-Saharan Africa. We aimed evaluate the of single dose tetanus, diphtheria acellular vaccine (Tdap) compared tetanus (Td) pregnant women Bamako, Mali assess toxin (PT) antibody response at birth.
In 2002, the Centre pour le Développement des Vaccins du Mali (CVD-Mali) was established as a partnership between Ministry of Health and University Maryland, Baltimore. Since its creation, CVD-Mali has been dedicated to describing epidemiology infectious diseases, supporting development vaccines, training team local researchers. participated in Global Enteric Multicenter Study from 2007 2010 Vaccine Impact on Diarrhea Africa study 2015 2018, where importance Shigella an enteric pathogen...
Neisseria meningitidis serogroups A, B, C, W, X, and Y cause outbreaks of meningococcal disease. Quadrivalent conjugate vaccines targeting the are available. A pentavalent vaccine that also includes serogroup X (NmCV-5) is under development.
Mortality attributed to respiratory illnesses is well characterized in children <5 years. However, there paucity of data among older populations. Here, we leveraged from the COVID-19 Vaccine Effectiveness Evaluation establish factors associated with mortality patients severe illness (SRI) Kenya and Mali. We enrolled (≥ 12 years) requiring hospitalization for SRI, defined as acute onset (≤ 14 days) at least two following: cough, fever (reported/measured temperature ≥38 °C), chills, rigors,...
Abstract Background Few studies describe the respiratory syncytial virus (RSV) burden in African populations, and most have utilized hospital-based surveillance. In Mali, no community-based exist of incidence or epidemiology RSV infection. This study provides first estimates Mali. Methods a cohort infants enrolled clinical trial maternal influenza vaccination, we estimate RSV-associated febrile illness 6 months life identify risk factors for infection progression to severe disease. Infants...
Measles deaths highlight immunization program gaps. In the Child Health and Mortality Prevention Surveillance study in Mali, we observed a rise under-5 measles-related 2022 that corresponded with increased measles cases at same time decline vaccine coverage Mali 2020.
Background Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis suggest clinical benefit, guidelines recommend use. Methods findings Healthy adult participants from the healthcare setting, later community,...
Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year life in low-resource countries.We conducted an open-label, individual-randomized trial Bamako, Mali. We assigned 600 aged 9-11 months receive measles (MV), yellow fever (YFV), meningococcal conjugate (MenAV) with or without pentavalent (PRV). assessed noninferiority (defined as a difference ≤10%) seroconversion seroresponse rates MV, YFV, MenAV....