Hannah E Atlas
A5027359550- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Food Security and Health in Diverse Populations
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Zoonotic diseases and public health
- Poverty, Education, and Child Welfare
- Microscopic Colitis
- Child Nutrition and Feeding Issues
- Migration, Health and Trauma
- Gut microbiota and health
- Child and Adolescent Health
- Global Health and Epidemiology
- HIV Research and Treatment
- Gender, Labor, and Family Dynamics
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Global Maternal and Child Health
- Antibiotic Use and Resistance
University of Washington
2017-2025
Abstract Background Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, precursor to stunting lifelong morbidity. Several promising vaccines are in development field efficacy trials will require consortium potential vaccine trial sites with up-to-date diarrhea incidence data. Methods The Enterics for Global Health (EFGH) surveillance study employ facility-based enrollment cases aged 6–35 months 3 follow-up establish rates document...
Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting are development, and phase 3 clinical trials imminent to determine efficacy against shigellosis. The Enterics for Global Health (EFGH) surveillance study designed the incidence medically attended shigellosis 6- 35-month-old 7 resource-limited settings. Here, we describe microbiological methods used isolate identify Shigella. We developed standardized laboratory protocol isolation identification by...
Background A major limitation to understanding the etiopathogenesis of environmental enteric dysfunction (EED) is lack a comprehensive, reproducible histologic framework for characterizing small bowel lesions. We hypothesized that development such system will identify unique histology features EED, and some might correlate with clinical severity. Methods Duodenal endoscopic biopsies from two cohorts where EED prevalent (Pakistan, Zambia) North American children without gluten sensitive...
Abstract Background Bacterial pathogens cause substantial diarrhea morbidity and mortality among children living in endemic settings, yet antimicrobial treatment is only recommended for dysentery or suspected cholera. Methods AntiBiotics Children with severe Diarrhea was a 7-country, placebo-controlled, double-blind efficacy trial of azithromycin 2–23 months age watery accompanied by dehydration malnutrition. We tested fecal samples enteric utilizing quantitative polymerase chain reaction to...
Rigorous data management systems and planning are essential to successful research projects, especially for large, multicountry consortium studies involving partnerships across multiple institutions. Here we describe the development implementation of procedures Enterics For Global Health (EFGH) Shigella surveillance study-a 7-country diarrhea study that will conduct facility-based concurrent with population-based enumeration a health care utilization survey estimate incidence...
Accurate estimation of diarrhea incidence from facility-based surveillance requires estimating the population at risk and accounting for case patients who do not seek care. The Enterics Global Health (EFGH) Shigella study will characterize denominators healthcare-seeking behavior proportions to calculate rates in children aged 6-35 months across 7 sites Africa, Asia, Latin America. use a hybrid design, supplementing with population-based surveys estimate size proportion brought care EFGH...
Children who have been discharged from hospital in sub-Saharan Africa remain at substantial risk of mortality the post-discharge period. Antimicrobial resistance (AMR) may be an important factor. We sought to determine prevalence and factors associated with AMR commensal Escherichia coli (E. coli) Kenyan children time discharge.Fecal samples were collected 406 aged 1-59 months western Kenya discharge cultured for E. coli. Susceptibility ampicillin, ceftriaxone, cefotaxime, ceftazidime,...
Abstract Background The Toto Bora trial tested whether a 5-day course of azithromycin reduced the risk re-hospitalization or death in 6 months following hospitalization among Kenyan children and found no overall benefit. We hypothesized that macrolide resistance gut microbes could modify azithromycin’s effect. Methods From June 2016 to November 2019, aged 1-59 were enrolled at hospital discharge randomized placebo. DNA from fecal samples E. coli isolates was analyzed for common genes. Cox...
The measurement of fecal inflammatory biomarkers among individuals presenting to care with diarrhea could improve the identification bacterial diarrheal episodes that would benefit from antibiotic therapy. We reviewed prior literature in this area and describe our proposed methods evaluate 4 Enterics for Global Health (EFGH) Shigella surveillance study. systematically studies since 1970 PubMed Embase assessed diagnostic characteristics identify episodes. extracted sensitivity specificity...
Comparative costs of public health interventions provide valuable data for decision making. However, the availability comprehensive and context-specific is often limited. The Enterics Global Health (EFGH) Shigella surveillance study-a facility-based diarrhea study across 7 countries-aims to generate evidence on system household associated with medically attended in children. EFGH working groups comprising representatives from each country (Bangladesh, Kenya, Malawi, Mali, Pakistan, Peru,...
Abstract Background Cytomegalovirus (CMV) viremia is associated with mortality in severely ill immunocompetent adults and hospitalized children HIV (CWH). We measured CMV HIV-exposed -unexposed Kenyan aged 1–59 months discharged from hospital determined its relationship postdischarge mortality. Methods DNA levels were plasma 1024 (97 of which exposed uninfected [HEU], 15 CWH). Poisson Cox proportional hazards regression models used to identify correlates ≥ 1000 IU/mL 
and estimate...
Stunting (length/height-for-age z-score < -2) is associated with significant morbidity and mortality among children under 5 years of age in sub-Saharan Africa. Children who are stunted recently hospitalized for acute illness may be at particularly elevated risk post-discharge mortality. In this cross-sectional analysis, we measured the prevalence stunting hospital discharge identified host, caregiver, environmental correlates aged 1-59 months Western Kenya enrolled Toto Bora Trial. Child...