A5114260307- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Helicobacter pylori-related gastroenterology studies
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Child Nutrition and Water Access
- Galectins and Cancer Biology
- Bacterial Identification and Susceptibility Testing
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Salmonella and Campylobacter epidemiology
- Antimicrobial Resistance in Staphylococcus
- Neonatal Respiratory Health Research
- Veterinary medicine and infectious diseases
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Global Maternal and Child Health
MRC Unit the Gambia
2015-2025
Memorial Sloan Kettering Cancer Center
2024
Centre Hospitalier Universitaire de Rennes
2022
Medical Research Council
1996-2021
London School of Hygiene & Tropical Medicine
2021
Ministry of Health and Social Welfare
2021
The University of Melbourne
2019
Peter Doherty Institute
2019
RELX Group (Netherlands)
2013
Washington University in St. Louis
2005-2007
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
Neonatal sepsis is a leading cause of neonatal mortality. New interventions are needed to decrease and mortality in regions with highest burden.To evaluate the efficacy intrapartum azithromycin reduce or mortality, as well maternal infections.This double-blind, placebo-controlled, randomized clinical trial enrolled followed up birthing parents their infants at 10 health facilities The Gambia Burkina Faso, West Africa, between October 2017 May 2021.Participants were assigned random receive...
Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting are development, and phase 3 clinical trials imminent to determine efficacy against shigellosis. The Enterics for Global Health (EFGH) surveillance study designed the incidence medically attended shigellosis 6- 35-month-old 7 resource-limited settings. Here, we describe microbiological methods used isolate identify Shigella. We developed standardized laboratory protocol isolation identification by...
Background Nasopharyngeal carriage of pneumococci is prevalent among children in developing countries but little known about the relationship nasopharyngeal cariage to invasive disease or way which spread within households. Objectives To determine prevalence healthy and sick Gambian investigate transmission Methods swabs were obtained by per nasal route cultured for on selective media. Pneumococci serotyped with use latex particles coated type-specific antisera. Results isolated from...
The pneumococcus is a frequent cause of pneumonia and other serious infections among young children in developing countries. Defining the pattern pneumococcal infection these countries important so that, with advent conjugate vaccines, rational vaccination policies can be developed.Children younger than 5 years age who attended clinics rural area Gambia, West Africa, were screened by assistants during 2-year period. Children predefined features suggestive diagnosis pneumonia, meningitis or...
Few studies on bacteraemia in Africa have been published. We aimed to prospectively identify the causative organisms of The Gambia and their relation clinical diagnoses, outcome antimicrobial susceptibility. Between November 2003 February 2005 we studied those admitted Medical Research Council hospital who were suspected having bacteraemia. documented features, outcome, pathogens identified susceptibility patterns, searched for factors associated with 871 patients had a blood culture taken....
Background:Staphylococcus aureus is a major human pathogen. Panton-Valentine leukocidin (PVL) virulence factor produced by some strains that causes leukocyte lysis and tissue necrosis. PVL-associated S. (PVL-SA) predominantly skin soft-tissue infections (SSTIs) but can also cause invasive such as necrotizing pneumonia. It carried both community-associated methicillin susceptible (CA-MSSA) resistant (CA-MRSA). This study aims to determine the prevalence of PVL-SA among patients seen at an...
Background. Despite improvements in infant mortality rates many developing countries including The Gambia, neonatal remains high and deaths are caused by infection. study described this paper was conducted to determine the bacterial viral etiology of serious infections Gambian infants younger than 91 days old. Methods. At a first level health facility 497 with symptoms that could indicate infection were enrolled, whom 239 1 or more signs 55 no investigated, yielding 17 cases positive...
Pneumoccal infection is one of the leading causes pneumonia, meningitis and septicaemia in developing countries. We have investigated possible risk factors for pneumococcal disease among children living a rural area The Gambia.A prospective case-control study was conducted which with were identified from attending out-patient under-fives clinics matched according to age healthy selected randomly local community. A questionnaire used investigate nutritional, medical, socioeconomic...
Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance bacteria, principally Streptococcuspneumoniae, >75% being serotypes covered by current pneumococcal conjugate vaccines. Multiple were frequently, notably Haemophilus influenzae (mostly nontypeable) together S. pneumoniae.
The effect of a Haemophilus influenzae type b (Hib) polyribosylribitol phosphate-tetanus toxoid conjugate vaccine (Hib/PRP-T) on oropharyngeal carriage Hib was studied during an efficacy trial in Gambian infants. Children were vaccinated with Hib/PRP-T and diphtheria-tetanus toxoids-pertussis (DTP) or DTP alone at ages 2, 3, 4 months. Groups 1000 children aged 1–2 years each year for years. detected by production halo antiserum agar plates. Carriage significantly lower among fully given...
Two thousand eight hundred ninety-eight children younger than 5 years old were investigated during a 2-year period in rural area of The Gambia for possible pneumonia, meningitis or septicemia. After clinical examination and appropriate investigations, 1014 diagnosed as having 31 100 Nine seven had final diagnosis malaria including 702 who satisfied the World Health Organization criteria pneumonia. A bacterial etiology was established 115 (11%) patients with 25 (81%) 29 (29%) suspected Overall
Journal Article Carriage Of Group B Streptococci In Pregnant Gambian Mothers And Their Infants Get access Rahaman O. Suara, Suara Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard A. Adegbola, Adegbola Reprints or correspondence: Dr. MRC Fajara, P. Box 273, Banjul, The Gambia, West Africa. Carol J. Baker, Baker Ousman Secka, Secka Edward K. Mulholland, Mulholland Brian M. Greenwood of Infectious Diseases, Volume 170, Issue 5, November 1994, Pages...
Summary Objectives To describe the characteristics of pneumococcal isolates obtained from patients with invasive disease in The Gambia. Methods Pneumococcal were children aged ≤6 years during a Haemophilus influenzae vaccine effectiveness study (1997–2002) and admitted to MRC hospital, Fajara, for routine care (1996–2003). Isolates identified, serotyped tested antibiotic susceptibility. Results Five hundred thirty one 518 patients; 55 (10.6%) died; 415 (79%) blood culture, 84 (16%) CSF, 42...
Streptococcus pneumoniae serotype 1 causes > 20% of invasive disease, among all age groups combined, in The Gambia. In contrast, it is rarely detected carriage studies. This study compares the molecular epidemiology S. causing disease Gambia between 1996 and 2005 to those carried nasopharynx 2004 2006. A total 127 36 nasopharyngeal isolates were recovered from individuals analyzed by serotyping, antibiotic susceptibility testing MLST. MLST analysis revealed 23 different sequence types (STs),...
ABSTRACT Helicobacter pylori is a globally important and genetically diverse gastric pathogen that infects most people in developing countries. Eradication efforts are complicated by antibiotic resistance, which varies frequency geographically. There very few data on resistance African strains. Sixty-four Gambian H. strains were tested for susceptibility. The role of rdxA metronidazole (Mtz) susceptibility was DNA transformation sequencing; RdxA protein variants interpreted terms structure....
Molecular diagnostics on human fecal samples have identified a larger burden of shigellosis than previously appreciated by culture. Evidence fold changes in immunoglobulin G (IgG) to conserved and type-specific Shigella antigens could be used validate the molecular assignment as etiology acute diarrhea support polymerase chain reaction (PCR)-based microbiologic end points for vaccine trials. We will test dried blood spots collected at enrollment 4 weeks later using bead-based immunoassays...
Streptococcus pneumoniae is an important cause of community acquired pneumonia, sepsis, meningitis and otitis media globally has been incriminated as a major serious childhood bacterial infections in The Gambia. Better understanding the dynamics transmission carriage will inform control strategies.This study was conducted among 196 mother-infant pairs recruited at birth from six villages West Kiang region Nasopharyngeal swabs were collected (within 12 hours delivery), 2, 5 months. Standard...
Abstract Background Pneumococcal conjugate vaccines (PCV) effectively prevent pneumococcal disease but the global impact of vaccination is hampered by cost PCV. The relevance and feasibility trials reduced dose schedules greatest in middle- low-income countries, such as Gambia, where PCV has been introduced with good control transmission vaccine-type pneumococci persists. We are conducting a large cluster-randomised, non-inferiority, field trial an alternative schedule compared to standard...
The Gambia, located in West Africa, is one of 7 country sites conducting the Enterics for Global Health (EFGH)