A5026435410- Helicobacter pylori-related gastroenterology studies
- Carcinogens and Genotoxicity Assessment
- Galectins and Cancer Biology
- Genetically Modified Organisms Research
- Eosinophilic Esophagitis
- Pesticide Exposure and Toxicity
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Plant Genetic and Mutation Studies
- Gastroesophageal reflux and treatments
- Mycobacterium research and diagnosis
- Glutathione Transferases and Polymorphisms
- Healthcare Decision-Making and Restraints
- Cancer Mechanisms and Therapy
- Phenothiazines and Benzothiazines Synthesis and Activities
- Testicular diseases and treatments
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Effects and risks of endocrine disrupting chemicals
- Pharmacological Receptor Mechanisms and Effects
- Consumer Attitudes and Food Labeling
- Occupational exposure and asthma
- Microscopic Colitis
- Berberine and alkaloids research
- Viral gastroenteritis research and epidemiology
Universidad de Costa Rica
2009-2023
Hospital Vozandes
2017
Creative Research Enterprises (United States)
2017
Universidad San Francisco de Quito
2017
Instituto de Investigaciones en Ciencias de la Salud
2009-2014
University of Illinois Chicago
2009
NYU Langone Health
2008
Yokohama City University Hospital
2008
Yokohama City University
2008
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
Central nervous system (CNS) germ cell tumors (GCT) have not been epidemiologically well described. Our study describes 2 population-based series of nonpineal CNS GCT. Data on all primary (malignant and nonmalignant) (ICD-O-3 sites: C70.0–C72.9, C75.1–C75.3) GCT diagnosed between 2000 2004 from the Brain Tumor Registry United States (CBTRUS) malignant 1992 2005 Surveillance, Epidemiology, End Results (SEER) were analyzed. Of 234 in CBTRUS, most common site was brain, NOS (31.6%). Males had a...
To report the results of International Nosocomial Infection Control Consortium (INICC) study conducted in Quito, Ecuador.A device-associated healthcare-acquired infection (DA-HAI) prospective surveillance from October 2013 to January 2015 2 adult intensive care units (ICUs) hospitals using United States Centers for Disease Control/National Healthcare Safety Network (CDC/NHSN) definitions and INICC methods.We followed 776 ICU patients 4818 bed-days. The central line-associated bloodstream...
The in vitro genotoxicity of imazalil and thiabendazole fungicides the insecticide chlorpyrifos, compounds used Costa Rican banana plantations, was evaluated with single-cell gel electrophoresis technique (comet assay). comet assay is a simple, rapid low cost for quantification DNA damage. This detects single- strand breaks alkali-labile sites individual cells. effects were analyzed by using human lymphocytes exposed to doses 0, 25, 50, 75 100 µg/ml each pesticide 30 min at 37°C. cells...
Cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes are involved in activation detoxification of many potential carcinogens. Genetic polymorphisms those have been found to influence the interindividual susceptibility cancer. Some associated specifically with gastric We conducted a study Costa Rican population, where cancer incidence mortality rates among highest world. investigated whether such variations affected risk developing Subjects included 31 cancer, 58 controls injures...
Helicobacter pylori colonizes the gastric mucosa and induces chronic inflammation. Using a mouse model of H. pylori-induced gastritis, we evaluated mRNA protein expression levels proinflammatory proangiogenic factors, as well histopathological changes in response to infection. Five- six-week-old female C57BL/6N mice were challenged with SS1 strain. Animals euthanized after 5-, 10-, 20-, 30-, 40- 50-weeks post Angpt1, Angpt2, VegfA, Tnf-α, bacterial colonization, inflammatory lesions...
To determine the association of Helicobacter pylori (H pylori) CagA(+) infection and pro-inflammatory polymorphisms genes interleukin (IL)-1RN IL-1B with risk gastric atrophy peptic ulcers in a dyspeptic population Costa Rica, country high incidence mortality cancer.Seven biopsy specimens, fasting blood sample questionnaire concerning nutritional sociodemographic factors were obtained from 501 consecutive patients who had undergone endoscopy for symptoms. A histopathological diagnosis was...
The purpose of this work was to determine if the occupational exposure those pesticides used at banana plantations’ packaging plants produces genetic damage somatic cells female workers. Chromosomal aberrations were scored in lymphocytes 20 women, 10 exposed workers and controls. Workers recruited from independent farms two locations Costa Rica, during January through June 1996 1997. These females had a minimum three months work, never received chemotherapy or radiotherapy did some these...
In order to study if banana fields labour exposure pesticides produces some kind of DNA damage, we determine the presence micronuclei in epithelial oral cells working women Guapiles and Siquirres, Costa Rica, as an effect biomarker. We also analyzed other abnormalities nucleus those such broken-egg, karyolysis or kariorrhexis, see there was genotoxicity citotoxicity. The group exposed worked packing bananas plant from different independent farms. control had never done any farming tasks;...
Helicobacter pylori infects a significant proportion of the world population and it is associated with pathologies which include chronic atrophic gastritis, peptic ulcer, gastric neoplasias such as adenocarcinoma MALT lymphoma. Costa Rica has high prevalence infection an elevated incidence cancer its mortality. The global structure for H. been established using MLST scheme. strains circulating in currently unknown. We characterized geographical origin 24 isolates from Rican patients....
Justificación y objetivo: H. pylori es un factor importante en el desarrollo de diversos tipos patologías gástricas como: gastritis crónica, úlcera péptica, adenocarcinoma tipo intestinal linfoma. Erradicar la infección una posibilidad terapia los pacientes con esas patologías. En estudio se analizó utilidad triple para erradicar por crónica péptica.Métodos: Se incluyeron 267 que atendieron Servicio Gastroenterología del HCG, entre enero mayo 2000. La presencia fue determinada ureasa rápida,...
Justification:The prevalence of gastric cancer (GC) with increased expression the HER2 oncoprotein shows important variations worldwide.Incidence and mortality rates GC in Costa Rica are among highest Latin America world; however, HER2-positive cases this country is unknown.Evaluation parameter to decide therapeutic approach for patients.The aim study was provide an estimation patients overexpressing oncogene Rica. Methods:The investigation carried out two phases.The first one consisted a...
The field of environmental mutagenesis or toxicology genetics aims to study the genetic damage that leads mutations produced by physical, chemical and biological agents, identify these agents analyze their interactions ways action. There are enough experimental epidemiological evidences implicating in oncogenes, tumor suppressor genes DNA repair as determinants onset progression neoplastic process. A valuable tool public occupational health is monitoring populations exposed potentially...
Introducción: Helicobacter pylori es una bacteria Gram negativa capaz de sobrevivir y multiplicarse en la mucosa gástrica humana. Es el factor más importante desarrollo gastritis atrófica crónica, úlcera péptica, linfoma MALT adenocarcinoma. Se estima que mitad población mundial está infectada con esta bacteria. La baja calidad vida costo económico causados por infección H. son importantes. Existen varios métodos para su diagnóstico, pero algunos invasivos, alto o ambos. Objetivo: Comparar...